RAB14 Antibody – Polyclonal

RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]

RAB14: a protein of the GTPase superfamily, Rab family. May be involved in vesicular trafficking and neurotransmitter release. Localized to the inner face of the cell membrane by a lipid-anchor.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 9q33.2

Cellular Component: apical plasma membrane; cytoplasmic vesicle membrane; cytosol; early endosome; early endosome membrane; Golgi apparatus; Golgi membrane; Golgi stack; intracellular; intracellular membrane-bound organelle; late endosome; lysosomal membrane; lysosome; nuclear envelope-endoplasmic reticulum network; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane; recycling endosome; rough endoplasmic reticulum; trans-Golgi network; trans-Golgi network transport vesicle

Molecular Function: GDP binding; glycoprotein binding; GTP binding; GTPase activity; myosin V binding; protein binding

Biological Process: apical protein localization; body fluid secretion; defense response to bacterium; embryonic development; endocytic recycling; fibroblast growth factor receptor signaling pathway; Golgi to endosome transport; intracellular protein transport; intracellular transport; metabolic process; nucleocytoplasmic transport; regulation of protein localization; small GTPase mediated signal transduction; vesicle-mediated transport