Anti-CDC37 Polyclonal Antibody – Cat# MBS178381

Anti- Cdc37 Picoband antibody, MBS178381, Western blotting
All lanes: Anti Cdc37 (MBS178381) at 0.5ug/ml
WB: 293T Whole Cell Lysate at 40ug
Predicted bind size: 44KD
Observed bind size: 44KD

CDC37 Antibody – Polyclonal

Name: CDC37 Antibody; Polyclonal; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178381
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178381

Description: Rabbit IgG polyclonal antibody for Hsp90 co-chaperone Cdc37(CDC37) detection. Tested with WB in Human.Background: Hsp90 co-chaperone Cdc37, also called P50CDC37, is a protein that in humans is encoded by the CDC37 gene. The protein encoded by… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cdc37, Polyclonal Antibody

Full Product Name

Anti-Cdc37 Antibody

Product Gene Name

anti-CDC37 antibody

Product Synonym Names

Hsp90 co-chaperone Cdc37; CDC 37; CDC37; CDC37 cell division cycle 37 homolog; CDC37 cell division cycle 37 S cerevisiae homolog; Cdc37 homolog; CDC37 protein; CDC37_HUMAN; CDC37A; Cell division cycle 37 homolog; Hsp90 chaperone protein kinase targeting subunit; Hsp90 chaperone protein kinase targeting subunit p50Cdc37; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co chaperone Cdc37; Hsp90 co-chaperone Cdc37; p50; p50Cdc37; S cerevisiae hypothetical protein CDC37; S. cerevisiae hypothetical protein CDC37 antibody; cell division cycle 37

Clonality

Polyclonal

Species Reactivity

Human

Form/Format

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen Affinity Purified

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

44,468 Da

OMIM

605065

3D Structure

ModBase 3D Structure for Q16543

Immunogen

E Coli-derived human Cdc37 recombinant protein (Position: M216-V378). Human Cdc37 shares 95.7% and 95.1% amino acid (aa) sequence identity with mouse and rat Cdc37, respectively.

Ig Type

Rabbit IgG

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-CDC37 antibody

Western Blot (WB)

Application Notes for anti-CDC37 antibody

Western Blot Concentration: 0.1-0.5ug/ml

Product References and Citations for anti-CDC37 antibody

1. Chen, G., Cao, P., Goeddel, D. V. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Molec. Cell 9: 401-410, 2002. 2. Vaughan, C. K., Mollapour, M., Smith, J. R., Truman, A., Hu, B., Good, V. M., Panaretou, B., Neckers, L., Clarke, P. A., Workman, P., Piper, P. W., Prodromou, C., Pearl, L. H.Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Molec. Cell 31: 886-895, 2008.

Other Notes

Small volumes of anti-CDC37 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDC37 purchase

MBS178381 is an antibody targeting CDC37. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for CDC37. It may not necessarily be applicable to this product.

NCBI GI #

5901922

NCBI GeneID

11140

NCBI Accession #

NP_008996.1

UniProt Primary Accession #

Q16543

UniProt Secondary Accession #

Q53YA2

UniProt Related Accession #

Q16543

GenBank Nucleotide #

NM_007065.3

NCBI Official Full Name

hsp90 co-chaperone Cdc37

NCBI Official Synonym Full Names

cell division cycle 37

NCBI Official Symbol

CDC37

NCBI Official Synonym Symbols

P50CDC37

UniProt Protein Name

Hsp90 co-chaperone Cdc37

UniProt Synonym Protein Names

Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37

Protein Family

Hsp90 co-chaperone

UniProt Gene Name

CDC37

UniProt Synonym Gene Names

CDC37A

UniProt Entry Name

CDC37_HUMAN

NCBI Protein Information

hsp90 co-chaperone Cdc37

NCBI Summary for CDC37

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]

UniProt Comments for CDC37

CDC37: a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; cytosol

Molecular Function: chaperone binding; heat shock protein binding; Hsp90 protein binding; kinase binding; protein binding; protein kinase binding; protein kinase regulator activity; protein-tyrosine kinase activity; unfolded protein binding

Biological Process: peptidyl-tyrosine phosphorylation; protein folding; protein stabilization; protein targeting; regulation of cyclin-dependent protein kinase activity

Research Articles on CDC37

1. Apart from these distinct Cdc37/Hsp90 interfaces, binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDC37 antibody

Reference Product	PubMed Publications
CDK4 antibody	>33 publications with CDC37 and CDK4
SRC antibody	>29 publications with CDC37 and SRC
CDK6 antibody	>7 publications with CDC37 and CDK6
HSP90AB1 antibody	>5 publications with CDC37 and HSP90AB1
EGFR antibody	>4 publications with CDC37 and EGFR
AKT1 antibody	>3 publications with CDC37 and AKT1
STK11 antibody	>3 publications with CDC37 and STK11
LRRK2 antibody	>2 publications with CDC37 and LRRK2
HSP90AA1 antibody	>2 publications with CDC37 and HSP90AA1

Pathways associated with anti-CDC37 antibody

Products by Pathway	Pathway Diagram
AhR Pathway antibodies	AhR Pathway Diagram
Constitutive Signaling By EGFRvIII Pathway antibodies	Constitutive Signaling By EGFRvIII Pathway Diagram
Constitutive Signaling By Ligand-Responsive EGFR Cancer Variants Pathway antibodies	Constitutive Signaling By Ligand-Responsive EGFR Cancer Variants Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Of Signal Transduction Pathway antibodies	Diseases Of Signal Transduction Pathway Diagram
LKB1 Signaling Events Pathway antibodies	LKB1 Signaling Events Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By EGFR In Cancer Pathway antibodies	Signaling By EGFR In Cancer Pathway Diagram

Diseases associated with anti-CDC37 antibody

Disease Name	Pubmed Publications
Leukemia Antibodies	>16 publications with CDC37 and Leukemia
Necrosis Antibodies	>11 publications with CDC37 and Necrosis
Gastrointestinal Diseases Antibodies	>8 publications with CDC37 and Gastrointestinal Diseases
Breast Neoplasms Antibodies	>8 publications with CDC37 and Breast Neoplasms
Inflammation Antibodies	>6 publications with CDC37 and Inflammation
Pancreatic Neoplasms Antibodies	>6 publications with CDC37 and Pancreatic Neoplasms
Cell Transformation, Neoplastic Antibodies	>6 publications with CDC37 and Cell Transformation, Neoplastic
Liver Neoplasms Antibodies	>5 publications with CDC37 and Liver Neoplasms
Neoplasms, Experimental Antibodies	>5 publications with CDC37 and Neoplasms, Experimental
Carcinoma, Hepatocellular Antibodies	>5 publications with CDC37 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-CDC37 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>14 publications with CDC37 and Blood
Brain Antibodies	>10 publications with CDC37 and Brain
Liver Antibodies	>9 publications with CDC37 and Liver
Lung Antibodies	>8 publications with CDC37 and Lung
Muscle Antibodies	>8 publications with CDC37 and Muscle
Bone Antibodies	>7 publications with CDC37 and Bone
Prostate Antibodies	>6 publications with CDC37 and Prostate
Embryonic Tissue Antibodies	>6 publications with CDC37 and Embryonic Tissue
Heart Antibodies	>5 publications with CDC37 and Heart
Kidney Antibodies	>4 publications with CDC37 and Kidney