Anti-CCN1 Polyclonal Antibody – Cat# MBS178382

Anti- CCN1 Picoband antibody, MBS178382, Western blotting
All lanes: Anti CCN1 (MBS178382) at 0.5ug/ml
Lane 1: Rat Thymus Tissue Lysate at 50ug
Lane 2: Rat Skeletal Muscle Tissue Lysate at 50ug
Lane 3: A431 Whole Cell Lysate at 40ug
Lane 4: SGC Whole Cell Lysate at 40ug
Lane 5: 22RV1 Whole Cell Lysate at 40ug
Predicted bind size: 42KDg
Observed bind size: 42KD

CCN1 Antibody – Polyclonal

Name: CCN1 Antibody; Polyclonal; Human/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178382
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178382

Description: Rabbit IgG polyclonal antibody for Protein CYR61(CYR61) detection. Tested with WB in Human;Rat.Background: Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCN1, Polyclonal Antibody

Full Product Name

Anti-CCN1 Antibody

Product Gene Name

anti-CCN1 antibody

Product Synonym Names

Protein CYR61; 3CH61; CCN 1; CCN family member 1; CCN1; CCN1; CYR 61; Cyr61; CYR61 protein; CYR61 protein precursor; CYR61 protein precursor; CYR61_HUMAN; Cysteine rich angiogenic inducer 61; Cysteine rich angiogenic inducer 61; Cysteine rich angiogenic inducer 61; Cysteine rich heparin binding protein 61; Cysteine-rich angiogenic inducer 61; GIG 1; GIG1; GIG1 protein; GIG1 protein; IBP-10; IGF-binding protein 10; Igfbp 10; IGFBP-10; IGFBP10; IGFBP10; Insulin like growth factor binding protein 10; Insulin like growth factor binding protein 10; Insulin like growth factor binding protein 10; Insulin-like growth factor-binding protein 10; Protein CYR61; Protein GIG1; cysteine-rich, angiogenic inducer, 61

Clonality

Polyclonal

Species Reactivity

Human, Rat

Form/Format

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen Affinity Purified

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

42,027 Da

OMIM

602369

3D Structure

ModBase 3D Structure for O00622

Immunogen

E Coli-derived human CCN1 recombinant protein (Position: K54-D381). Human CCN1 shares 91.8% and 92.1% amino acid (aa) sequence identity with mouse and rat CCN1, respectively.

Ig Type

Rabbit IgG

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-CCN1 antibody

Western Blot (WB)

Application Notes for anti-CCN1 antibody

Western Blot Concentration: 0.1-0.5ug/ml

Product References and Citations for anti-CCN1 antibody

1. Lau LF (October 2011). "CCN1/CYR61: the very model of a modern matricellular protein". Cell. Mol. Life Sci. 68 (19): 3149-63. 2. Jay P, Berge-Lefranc JL, Marsollier C, Mejean C, Taviaux S, Berta P (May 1997). "The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p". Oncogene 14 (14): 1753-7. 3. Jun JI, Lau LF (December 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nature Reviews Drug Discovery 10 (12): 945-63.

Other Notes

Small volumes of anti-CCN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCN1 purchase

MBS178382 is an antibody targeting CCN1. Reactive in Human, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CCN1. It may not necessarily be applicable to this product.

NCBI GI #

31542331

NCBI GeneID

3491

NCBI Accession #

NP_001545.2

UniProt Primary Accession #

O00622

UniProt Secondary Accession #

O14934; O43775; Q9BZL7

UniProt Related Accession #

O00622

GenBank Nucleotide #

NM_001554.4

NCBI Official Full Name

protein CYR61

NCBI Official Synonym Full Names

cysteine rich angiogenic inducer 61

NCBI Official Symbol

CYR61

NCBI Official Synonym Symbols

CCN1; GIG1; IGFBP10

UniProt Protein Name

Protein CYR61

UniProt Synonym Protein Names

CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1

Protein Family

G1/S-specific cyclin

UniProt Gene Name

CYR61

UniProt Synonym Gene Names

CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10

UniProt Entry Name

CYR61_HUMAN

NCBI Protein Information

protein CYR61

NCBI Summary for CCN1

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

UniProt Comments for CCN1

CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: extracellular matrix binding; heparin binding; insulin-like growth factor binding; integrin binding

Biological Process: anatomical structure morphogenesis; cell adhesion; cell proliferation; cell-cell signaling; chemotaxis; extracellular matrix organization and biogenesis; intussusceptive angiogenesis; negative regulation of apoptosis; osteoblast differentiation; positive regulation of BMP signaling pathway; positive regulation of caspase activity; positive regulation of cell migration; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth

Research Articles on CCN1

1. c-Src regulates secreted proteins, including the exosomal Cyr61, which are involved in modulating the metastatic potential of triple negative breast cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCN1 antibody

Reference Product	PubMed Publications
JUN antibody	>100 publications with CCN1 and JUN
FOS antibody	>20 publications with CCN1 and FOS
CTNNB1 antibody	>18 publications with CCN1 and CTNNB1
RHOA antibody	>11 publications with CCN1 and RHOA
MKL1 antibody	>7 publications with CCN1 and MKL1
SRF antibody	>6 publications with CCN1 and SRF
ITGAV antibody	>1 publications with CCN1 and ITGAV

Pathways associated with anti-CCN1 antibody

Products by Pathway	Pathway Diagram
Hypertrophy Model Pathway antibodies	Hypertrophy Model Pathway Diagram
Oncostatin M Signaling Pathway antibodies	Oncostatin M Signaling Pathway Diagram
Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies	Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
RhoA Signaling Pathway antibodies	RhoA Signaling Pathway Diagram
Amb2 Integrin Signaling Pathway antibodies	Amb2 Integrin Signaling Pathway Diagram

Diseases associated with anti-CCN1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>65 publications with CCN1 and Inflammation
Disease Models, Animal Antibodies	>50 publications with CCN1 and Disease Models, Animal
Neoplasm Metastasis Antibodies	>49 publications with CCN1 and Neoplasm Metastasis
Breast Neoplasms Antibodies	>47 publications with CCN1 and Breast Neoplasms
Fibrosis Antibodies	>43 publications with CCN1 and Fibrosis
Nervous System Diseases Antibodies	>32 publications with CCN1 and Nervous System Diseases
Necrosis Antibodies	>27 publications with CCN1 and Necrosis
Brain Diseases Antibodies	>23 publications with CCN1 and Brain Diseases
Neoplasms, Experimental Antibodies	>23 publications with CCN1 and Neoplasms, Experimental
Lung Neoplasms Antibodies	>23 publications with CCN1 and Lung Neoplasms

Organs/Tissues associated with anti-CCN1 antibody

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>192 publications with CCN1 and Connective Tissue
Vascular Antibodies	>139 publications with CCN1 and Vascular
Bone Antibodies	>88 publications with CCN1 and Bone
Muscle Antibodies	>83 publications with CCN1 and Muscle
Embryonic Tissue Antibodies	>57 publications with CCN1 and Embryonic Tissue
Lung Antibodies	>52 publications with CCN1 and Lung
Brain Antibodies	>41 publications with CCN1 and Brain
Skin Antibodies	>35 publications with CCN1 and Skin
Prostate Antibodies	>34 publications with CCN1 and Prostate
Liver Antibodies	>32 publications with CCN1 and Liver