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Integrin Alpha 5 (ITGA5) Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178399

Description: Rabbit IgG polyclonal antibody for Integrin alpha-5(ITGA5) detection. Tested with WB in Human;Mouse;Rat.Background: Integrin alpha-5, also known as FNRA or VLA5A, is a protein that in humans is encoded by the ITGA5 gene. The product of this gene… More details

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Product Overview

Online Datasheet in PDF
Product Name
Integrin alpha 5 (ITGA5), Polyclonal Antibody
Full Product Name
Anti-Integrin alpha 5 Antibody
Product Gene Name
anti-ITGA5 antibody
Product Synonym Names
Integrin alpha-5; CD49 antigen-like family member E; CD49e; Fibronectin Receptor alpha; Fibronectin receptor subunit alpha; Fibronectin receptor, alpha subunit; FNRA; Integrin alpha 5 (fibronectin receptor alpha); Integrin alpha-5; Integrin alpha-5 light chain; Integrin alpha-F; Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITA5_HUMAN; ITGA 5; ITGA5; Very Late Activation Protein 5 alpha; Very late activation protein 5, alpha subunit; VLA-5; VLA5; VLA5A; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Clonality
Polyclonal
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
114,536 Da
OMIM
135620
3D Structure
ModBase 3D Structure for P08648
Immunogen
E Coli-derived human Integrin alpha 5 recombinant protein (Position: E787-E992). Human Integrin alpha 5 shares 86% amino acid (aa) sequence identity with mouse Integrin alpha 5.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ITGA5 antibody
Western Blot (WB)
Application Notes for anti-ITGA5 antibody
Western Blot Concentration: 0.1-0.5ug/ml

Western Blot (WB) of anti-ITGA5 antibody

Anti- Integrin alpha 5 Picoband antibody, MBS178399, Western blotting
All lanes: Anti Integrin alpha 5 (MBS178399) at 0.5ug/ml
WB: Recombinant Human Integrin alpha 5 Protein 0.5ng
Predicted bind size: 39KD
Observed bind size: 39KD
Anti-ITGA5 Polyclonal Antibody – Cat# MBS178399

Western Blot (WB) of anti-ITGA5 antibody

Anti- Integrin alpha 5 Picoband antibody, MBS178399, Western blotting
All lanes: Anti Integrin alpha 5 (MBS178399) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Mouse Brain Tissue Lysate at 50ug
Lane 3: MM231 Whole Cell Lysate at 40ug
Lane 4: HELA Whole Cell Lysate at 40ug
Lane 5: JURKAT Whole Cell Lysate at 40ug
Lane 6: 293T Whole Cell Lysate at 40ug
Lane 7: NEURO Whole Cell Lysate at 40ug
Lane 8: PC-12 Whole Cell Lysate at 40ug
Predicted bind size: 115KD
Observed bind size: 220KD
Anti-ITGA5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS178399

Product References and Citations for anti-ITGA5 antibody

1. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). 2. "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)"

Other Notes

Small volumes of anti-ITGA5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITGA5 purchase

MBS178399 is an antibody targeting ITGA5. Also known as Anti-Integrin alpha 5 Antibody. Reactive in Human, Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for ITGA5. It may not necessarily be applicable to this product.

NCBI GI #
938148811
NCBI GeneID
3678
NCBI Accession #
NP_002196.3
UniProt Primary Accession #
P08648
UniProt Secondary Accession #
Q96HA5
UniProt Related Accession #
P08648
GenBank Nucleotide #
NM_002205.3
NCBI Official Full Name
integrin alpha-5 preproprotein
NCBI Official Synonym Full Names
integrin subunit alpha 5
NCBI Official Symbol
ITGA5
NCBI Official Synonym Symbols
FNRA; CD49e; VLA-5; VLA5A
UniProt Protein Name
Integrin alpha-5
UniProt Synonym Protein Names
CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen: CD49e
Protein Family
Integrin
UniProt Gene Name
ITGA5
UniProt Synonym Gene Names
FNRA
UniProt Entry Name
ITA5_HUMAN
NCBI Protein Information
integrin alpha-5

NCBI Summary for ITGA5

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
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UniProt Comments for ITGA5

ITGA5: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV- 1 Tat. Belongs to the integrin alpha chain family.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q11-q13

Cellular Component: cell surface; cytoplasmic vesicle; endoplasmic reticulum; external side of plasma membrane; focal adhesion; Golgi apparatus; integrin complex; intercellular junction; plasma membrane; ruffle; synapse

Molecular Function: epidermal growth factor receptor binding; integrin binding; metal ion binding; platelet-derived growth factor receptor binding; protein binding; vascular endothelial growth factor receptor 2 binding; viral receptor activity

Biological Process: angiogenesis; cell adhesion; cell-cell adhesion mediated by integrin; cell-substrate adhesion; cell-substrate junction assembly; entry of virus into host cell; extracellular matrix organization and biogenesis; heterophilic cell adhesion; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration; memory; positive regulation of cell migration; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; wound healing, spreading of epidermal cells
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Research Articles on ITGA5

1. Data suggest that the binding, but not the internalization of photoreceptor outer segments (POS) confers protective effects on retinal pigment epithelium (RPE) cells through the alphavbeta5 integrin/focal adhesion kinase (FAK)/PGC-1alpha pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ITGA5 antibody

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 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram

Diseases associated with anti-ITGA5 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >13 publications with ITGA5 and Carcinoma
 Neoplasm Invasiveness Antibodies  >10 publications with ITGA5 and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >9 publications with ITGA5 and Neoplasm Metastasis
 Inflammation Antibodies  >7 publications with ITGA5 and Inflammation
 Breast Neoplasms Antibodies  >7 publications with ITGA5 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with ITGA5 and Neoplasms, Experimental
 Lung Diseases Antibodies  >3 publications with ITGA5 and Lung Diseases
 Cardiovascular Diseases Antibodies  >3 publications with ITGA5 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with ITGA5 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >3 publications with ITGA5 and Liver Diseases

Organs/Tissues associated with anti-ITGA5 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >14 publications with ITGA5 and Bone
 Vascular Antibodies  >12 publications with ITGA5 and Vascular
 Embryonic Tissue Antibodies  >8 publications with ITGA5 and Embryonic Tissue
 Blood Antibodies  >8 publications with ITGA5 and Blood
 Lung Antibodies  >8 publications with ITGA5 and Lung
 Bone Marrow Antibodies  >8 publications with ITGA5 and Bone Marrow
 Muscle Antibodies  >8 publications with ITGA5 and Muscle
 Liver Antibodies  >7 publications with ITGA5 and Liver
 Uterus Antibodies  >7 publications with ITGA5 and Uterus
 Brain Antibodies  >5 publications with ITGA5 and Brain
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