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Calcitonin (CALCA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178437

Rabbit IgG polyclonal antibody for Calcitonin gene-related peptide 1 (CALCA) detection. Background: Calcitonin, also known as CALCA, is a peptide hormone synthesized by the parafollicular cells of the thyroid. It is mapped to 11p15.2. Calcitonin belongs to… More details

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Product Overview

Online Datasheet in PDF
Product Name
Calcitonin (CALCA), Polyclonal Antibody
Full Product Name
Anti-Calcitonin Antibody
Product Gene Name
anti-CALCA antibody
Product Synonym Names
Alpha CGRP; alpha type CGRP; CALC1; CALC 1; CALC A; CALCA; calcitonin1; calcitonin-1; calcitonin 1; CGRP1; CGRP 1; CGRP-1 |CT; katacalcin; KC; Q99JA0; Calcitonin gene-related peptide 1; calcitonin related polypeptide alpha
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
No cross reactivity with other proteins.
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
15,141 Da
3D Structure
ModBase 3D Structure for Q99JA0
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse Calcitonin (83-119aa SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF), different from the related human sequence by four amino acids, and identical to the related rat sequence.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CALCA antibody
Immunohistochemistry (IHC) Paraffin
Application Notes for anti-CALCA antibody
Immunohistochemisry Paraffin: 0.5-1mug/ml; Tested Species: Mouse, Rat
Tested Species:In-house tested species with positive results.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.

Immunohistochemistry (IHC) of anti-CALCA antibody

Calcitonin was detected in paraffin-embedded sections of mouse lung tissues using rabbit anti- Calcitonin Antigen Affinity purified polyclonal antibody at 1ug/mL. The immunohistochemical section was developed using SABC method.
Rabbit Anti-CALCA Polyclonal Antibody – Cat# MBS178437

Immunohistochemistry (IHC) of anti-CALCA antibody

Calcitonin was detected in paraffin-embedded sections of rat lung tissues using rabbit anti- Calcitonin Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.
Rabbit Anti-CALCA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS178437

Product References and Citations for anti-CALCA antibody

1. Alevizaki, M., Stevenson, J. C., Girgis, S. I., MacIntyre, I., Legon, S. Altered calcitonin gene in a young patient with osteoporosis.Brit. Med. J. 298: 1215-1216, 1989. Note: Retraction: Brit. Med. J. 299: 235 only, 1989.
2. Breimer, L. H., MacIntyre, I., Zaidi, M. Peptides from the calcitonin genes: molecular genetics, structure and function. Biochem. J. 255: 377-390, 1988.
3. Edbrooke, M. R., Parker, D., McVey, J. H., Riley, J. H., Sorenson, G. D., Pettengill, O. S., Craig, R. K. Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma. EMBO J. 4: 715-724, 1985.

Other Notes

Small volumes of anti-CALCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CALCA purchase

MBS178437 is an antibody targeting CALCA. Also known as Anti-Calcitonin Antibody. Reactive in Mouse, Rat
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CALCA. It may not necessarily be applicable to this product.

NCBI GI #
76880463
NCBI GeneID
12310
NCBI Accession #
NP_001029126.1
UniProt Primary Accession #
Q99JA0
UniProt Related Accession #
P70160; Q99JA0
GenBank Nucleotide #
NM_001033954.3
NCBI Official Full Name
calcitonin gene-related peptide 1 isoform Cgrp preproprotein
NCBI Official Synonym Full Names
calcitonin/calcitonin-related polypeptide, alpha
NCBI Official Symbol
Calca
NCBI Official Synonym Symbols
CA; Ct; Ctn; Calc; Cgrp; CGRP1; Calc1; CGRP-1
UniProt Protein Name
Calcitonin gene-related peptide 1
UniProt Synonym Protein Names
Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I
Protein Family
Calcitonin
UniProt Gene Name
Calca
UniProt Synonym Gene Names
Calc; CGRP-I
UniProt Entry Name
CALCA_MOUSE
NCBI Protein Information
calcitonin gene-related peptide 1

NCBI Summary for CALCA

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]
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UniProt Comments for CALCA

CALCA iso3: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: axon; cell soma; cytoplasm; extracellular region; extracellular space; intracellular; neuron projection; nucleus; terminal button

Molecular Function: calcitonin receptor binding; receptor binding

Biological Process: adenylate cyclase activation; cellular calcium ion homeostasis; detection of temperature stimulus involved in sensory perception of pain; feeding behavior; G-protein signaling, adenylate cyclase activating pathway; inflammatory response; negative regulation of blood pressure; negative regulation of neurological process; negative regulation of ossification; negative regulation of smooth muscle contraction; neuromuscular junction development; neuropeptide signaling pathway; positive regulation of cell adhesion; positive regulation of ossification; regulation of blood pressure; regulation of heart contraction; regulation of heart rate; regulation of systemic arterial blood pressure by neurological process; response to heat; response to pain; sperm capacitation; vasodilation; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure
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Research Articles on CALCA

1. SHH may affect alveolar bone healing by interacting with CGRP-positive sensory neurons and thus regulate the socket's healing process after tooth extraction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CALCA antibody

 Products by Pathway  Pathway Diagram
 Calcitonin-like Ligand Receptors Pathway antibodies  Calcitonin-like Ligand Receptors Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-CALCA antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with CALCA and Inflammation
 Lung Diseases Antibodies  >12 publications with CALCA and Lung Diseases
 Hypertension Antibodies  >6 publications with CALCA and Hypertension
 Pain Antibodies  >6 publications with CALCA and Pain
 Migraine Disorders Antibodies  >5 publications with CALCA and Migraine Disorders
 Headache Antibodies  >5 publications with CALCA and Headache
 Neurogenic Inflammation Antibodies  >4 publications with CALCA and Neurogenic Inflammation
 Kidney Diseases Antibodies  >3 publications with CALCA and Kidney Diseases
 Necrosis Antibodies  >3 publications with CALCA and Necrosis
 Migraine without Aura Antibodies  >2 publications with CALCA and Migraine without Aura

Organs/Tissues associated with anti-CALCA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with CALCA and Blood
 Thyroid Antibodies  >11 publications with CALCA and Thyroid
 Brain Antibodies  >9 publications with CALCA and Brain
 Spinal Cord Antibodies  >4 publications with CALCA and Spinal Cord
 Embryonic Tissue Antibodies  >2 publications with CALCA and Embryonic Tissue
 Bone Marrow Antibodies  >1 publications with CALCA and Bone Marrow
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