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GRO Gamma (CXCL3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178441

Rabbit IgG polyclonal antibody for C-X-C motif chemokine 3 (CXCL3) detection. Background: Chemokine (C-X-C motif) ligand 3 (CXCL3), also known as GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b), is a small cytokine belonging to the… More details

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Product Overview

Online Datasheet in PDF
Product Name
GRO gamma (CXCL3), Polyclonal Antibody
Full Product Name
Anti-GRO gamma Antibody
Product Gene Name
anti-CXCL3 antibody
Product Synonym Names
Cinc 2; Cinc2; Cinc-2; CINC 2b; CINC2b; CINC-2b; CXCL 3; CXCL3; Dcip1; Gm1960; GRO protein gamma; GRO-gamma; GRO-gamma(1-73); GRO-gamma(5-73); GRO3; GRO3 oncogene; GROG; MGSA gamma; MIP 2b; MIP2b; MIP-2b; MIP2-beta; MIP 2B; MIP2B; MIP-2B; SCYB3; Q6W5C0; C-X-C motif chemokine 3; C-X-C motif chemokine ligand 3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
No cross reactivity with other proteins.
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
10,686 Da
3D Structure
ModBase 3D Structure for Q6W5C0
Immunogen
E Coli-derived mouse GRO gamma recombinant protein (Position: S32-S100). Mouse GRO gamma shares 60.6% and 90.6% amino acid (aa) sequence identity with human and rat GRO gamma, respectively.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CXCL3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CXCL3 antibody
Western Blot: 0.1-0.5mug/ml; Tested Species: Mouse
ELISA: 0.1-0.5mug/ml; Tested Species: Mouse
Tested Species:In-house tested species with positive results.
Other applications have not been tested.

Western Blot (WB) of anti-CXCL3 antibody

Western blot analysis of GRO gamma expression in mouse lung extract (lane 1) and mouse spleen extract (lane 2). GRO gamma at 25KD was detected using rabbit anti- GRO gamma Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.
Rabbit Anti-CXCL3 Polyclonal Antibody – Cat# MBS178441

Product References and Citations for anti-CXCL3 antibody

1. Ahuja SK, Murphy PM (August 1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". J. Biol. Chem. 271 (34): 20545-50.
2. Farioli-Vecchioli S, Cinà I, Ceccarelli M, Micheli L, Leonardi L, Ciotti MT, De Bardi M, Di Rocco C, Pallini R, Cavallaro S, Tirone F (October 2012). "Tis21 knock-out enhances the frequency of medulloblastoma in patched1 heterozygous mice by inhibiting the cxcl3-dependent migration of cerebellar neurons". The Journal of neuroscience : the official journal of the Society for Neuroscience 32 (44): 15547-15564.
3. Smith DF, Galkina E, Ley K, Huo Y (November 2005). "GRO family chemokines are specialized for monocyte arrest from flow". Am. J. Physiol. Heart Circ. Physiol. 289 (5): H1976-84.

Other Notes

Small volumes of anti-CXCL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL3 purchase

MBS178441 is an antibody targeting CXCL3. Also known as Anti-GRO gamma Antibody. Reactive in Mouse
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL3. It may not necessarily be applicable to this product.

NCBI GI #
42600573
NCBI GeneID
330122
NCBI Accession #
NP_976065.1
UniProt Primary Accession #
Q6W5C0
UniProt Secondary Accession #
Q3UNK9
UniProt Related Accession #
Q6W5C0
GenBank Nucleotide #
NM_203320.3
NCBI Official Full Name
C-X-C motif chemokine 3
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 3
NCBI Official Symbol
Cxcl3
NCBI Official Synonym Symbols
Dcip1; Gm1960
UniProt Protein Name
C-X-C motif chemokine 3
UniProt Synonym Protein Names
Dendritic cell inflammatory protein 1
Protein Family
C-X-C motif chemokine
UniProt Gene Name
Cxcl3
UniProt Entry Name
CXCL3_MOUSE
NCBI Protein Information
C-X-C motif chemokine 3

NCBI Summary for CXCL3

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. [provided by RefSeq, May 2013]
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UniProt Comments for CXCL3

CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding; protein binding

Biological Process: elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; neutrophil chemotaxis; regulation of cell proliferation; response to lipopolysaccharide
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Research Articles on CXCL3

1. Tis21 induces migration of cerebellar granule neuron precursor cells through Cxcl3, which may represent a novel target for medulloblastoma therapy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXCL3 antibody

 Reference Product  PubMed Publications
 Cxcl1 antibody  >118 publications with CXCL3 and Cxcl1
 Cxcl2 antibody  >116 publications with CXCL3 and Cxcl2
 Ccl20 antibody  >46 publications with CXCL3 and Ccl20
 Cxcl5 antibody  >46 publications with CXCL3 and Cxcl5
 Cxcl10 antibody  >25 publications with CXCL3 and Cxcl10
 Cxcr2 antibody  >17 publications with CXCL3 and Cxcr2
 Cxcl12 antibody  >8 publications with CXCL3 and Cxcl12
 Cxcr3 antibody  >8 publications with CXCL3 and Cxcr3
 Ccr7 antibody  >3 publications with CXCL3 and Ccr7
 Ccr1 antibody  >3 publications with CXCL3 and Ccr1

Pathways associated with anti-CXCL3 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram
 TNF Signaling Pathway antibodies  TNF Signaling Pathway Diagram

Diseases associated with anti-CXCL3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >89 publications with CXCL3 and Inflammation
 Necrosis Antibodies  >40 publications with CXCL3 and Necrosis
 Lung Diseases Antibodies  >16 publications with CXCL3 and Lung Diseases
 Skin Diseases Antibodies  >11 publications with CXCL3 and Skin Diseases
 Death Antibodies  >8 publications with CXCL3 and Death
 Fibrosis Antibodies  >7 publications with CXCL3 and Fibrosis
 Lung Neoplasms Antibodies  >6 publications with CXCL3 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >6 publications with CXCL3 and Neoplasms, Experimental
 Heart Diseases Antibodies  >4 publications with CXCL3 and Heart Diseases
 Lung Injury Antibodies  >4 publications with CXCL3 and Lung Injury

Organs/Tissues associated with anti-CXCL3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >72 publications with CXCL3 and Blood
 Lung Antibodies  >22 publications with CXCL3 and Lung
 Skin Antibodies  >12 publications with CXCL3 and Skin
 Mammary Gland Antibodies  >7 publications with CXCL3 and Mammary Gland
 Bone Marrow Antibodies  >7 publications with CXCL3 and Bone Marrow
 Uncharacterized Tissue Antibodies  >1 publications with CXCL3 and Uncharacterized Tissue
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