Rabbit Anti-WDR1 Polyclonal Antibody – Cat# MBS178462

Western blot analysis of WDR1 expression in rat liver extract (lane 1), mouse brain extract (lane 2) and A431 whole cell lysates (lane 3). WDR1 at 66KD was detected using rabbit anti-WDR1 Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.

WDR1 Antibody – Rabbit Polyclonal

Name: WDR1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178462
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178462

Rabbit IgG polyclonal antibody for WD repeat-containing protein 1 (WDR1) detection. Background: WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene. It is mapped to 4p16.1. This gene encodes a protein containing 9 WD… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

WDR1, Polyclonal Antibody

Full Product Name

Anti-WDR1 Antibody

Product Gene Name

anti-WDR1 antibody

Product Synonym Names

AIP1; NORI 1; NORI-1; wdr1; O75083; WD repeat-containing protein 1; WD repeat domain 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat
No cross reactivity with other proteins.

Form/Format

Lyophilized

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

50,694 Da

OMIM

604734

3D Structure

ModBase 3D Structure for O75083

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human WDR1 (552-579aa MDMMVYVWTLSDPETRVKIQDAHRLHHV), different from the related mouse and rat sequences by one amino acid.

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-WDR1 antibody

Western Blot (WB)

Application Notes for anti-WDR1 antibody

Western Blot: 0.1-0.5mug/ml; Tested Species: Human, Mouse, Rat
Tested Species:In-house tested species with positive results.
Other applications have not been tested.

Product References and Citations for anti-WDR1 antibody

1. "Entrez Gene: WDR1 WD repeat domain 1".
2. Adler HJ, Winnicki RS, Gong TW, Lomax MI (May 1999). "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein". Genomics 56 (1): 59-69.
3. Fujibuchi T, Abe Y, Takeuchi T, et al. (2005). "AIP1/WDR1 supports mitotic cell rounding". Biochem. Biophys. Res. Commun. 327 (1): 268-75.

Other Notes

Small volumes of anti-WDR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WDR1 purchase

MBS178462 is an antibody targeting WDR1. Reactive in Human, Mouse, Rat
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for WDR1. It may not necessarily be applicable to this product.

NCBI GI #

53729352

NCBI GeneID

9948

NCBI Accession #

NP_005103.2

UniProt Primary Accession #

O75083

UniProt Secondary Accession #

O75313; Q8N6E5; Q9UG05; Q9UG78; Q9UQE0; A8K6E9; A8MPU4

UniProt Related Accession #

O75083

GenBank Nucleotide #

NM_005112.4

NCBI Official Full Name

WD repeat-containing protein 1 isoform 2

NCBI Official Synonym Full Names

WD repeat domain 1

NCBI Official Symbol

WDR1

NCBI Official Synonym Symbols

AIP1; NORI-1; HEL-S-52

UniProt Protein Name

WD repeat-containing protein 1

UniProt Synonym Protein Names

Actin-interacting protein 1; AIP1; NORI-1

Protein Family

WD repeat-containing protein

UniProt Gene Name

WDR1

UniProt Synonym Gene Names

AIP1

UniProt Entry Name

WDR1_HUMAN

NCBI Protein Information

WD repeat-containing protein 1

NCBI Summary for WDR1

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for WDR1

WDR1: a WD40 repeat cytoskeletal protein that induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Three alternatively spliced human isoforms have been described.

Protein type: Actin-binding

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: cytoplasm; cytosol; extracellular region

Biological Process: platelet degranulation; sensory perception of sound

Research Articles on WDR1

1. Demonstrate a previously unanticipated role of Aip1 in regulating the structure and remodeling of intestinal epithelial junctions and early steps of epithelial morphogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-WDR1 antibody

Products by Pathway	Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Hypertrophy Model Pathway antibodies	Hypertrophy Model Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram
Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies	Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with anti-WDR1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>8 publications with WDR1 and Nervous System Diseases
Inflammation Antibodies	>5 publications with WDR1 and Inflammation
Carcinoma Antibodies	>3 publications with WDR1 and Carcinoma
Neoplasm Metastasis Antibodies	>2 publications with WDR1 and Neoplasm Metastasis
Cardiovascular Diseases Antibodies	>2 publications with WDR1 and Cardiovascular Diseases
Heart Diseases Antibodies	>1 publications with WDR1 and Heart Diseases
Breast Neoplasms Antibodies	>1 publications with WDR1 and Breast Neoplasms
Liver Diseases Antibodies	>1 publications with WDR1 and Liver Diseases
Adenocarcinoma Antibodies	>1 publications with WDR1 and Adenocarcinoma
Cell Transformation, Neoplastic Antibodies	>1 publications with WDR1 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-WDR1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>7 publications with WDR1 and Blood
Ear Antibodies	>5 publications with WDR1 and Ear
Brain Antibodies	>5 publications with WDR1 and Brain
Nerve Antibodies	>4 publications with WDR1 and Nerve
Muscle Antibodies	>4 publications with WDR1 and Muscle
Heart Antibodies	>4 publications with WDR1 and Heart
Bone Antibodies	>4 publications with WDR1 and Bone
Embryonic Tissue Antibodies	>3 publications with WDR1 and Embryonic Tissue
Bone Marrow Antibodies	>3 publications with WDR1 and Bone Marrow
Thyroid Antibodies	>3 publications with WDR1 and Thyroid