Rabbit Anti-CPB2 Polyclonal Antibody – Cat# MBS178498

Western blot analysis of CPB2 expression in mouse liver extract (lane 1). CPB2 at 48KD was detected using rabbit anti- CPB2 Antigen Affinity purified polyclonal antibody at 0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.

CPB2 Antibody – Rabbit Polyclonal

Name: CPB2 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178498
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178498

Rabbit IgG polyclonal antibody for Carboxypeptidase B2 (CPB2) detection. Background: Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that,… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CPB2, Polyclonal Antibody

Full Product Name

Anti-CPB2 Antibody

Product Gene Name

anti-CPB2 antibody

Product Synonym Names

Carboxypeptidase U; CarboxypeptidaseU; CarboxypeptidaseB2; Carboxypeptidase B2; CP B2; CPB2; CPB 2; CPU; PCPB; Procarboxypeptidase B; Procarboxypeptidase R; Procarboxypeptidase U; TAFI; Q96IY4; Carboxypeptidase B2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse
No cross reactivity with other proteins.

Form/Format

Lyophilized

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

48,871 Da

3D Structure

ModBase 3D Structure for Q9JHH6

Immunogen

E Coli-derived mouse CPB2 recombinant protein (Position: K165-D387). Mouse CPB2 shares 86.1% and 96.9% amino acid (aa) sequence identity with human and rat CPB2, respectively.

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-CPB2 antibody

Western Blot (WB)

Application Notes for anti-CPB2 antibody

Western Blot: 0.1-0.5mug/ml; Tested Species: Mouse
Tested Species:In-house tested species with positive results.
Other applications have not been tested.

Product References and Citations for anti-CPB2 antibody

1. Boffa MB, Reid TS, Joo E, Nesheim ME, Koschinsky ML (May 1999). "Characterization of the gene encoding human TAFI (thrombin-activable fibrinolysis inhibitor; plasma procarboxypeptidase B)". Biochemistry 38 (20): 6547-58.
2. Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D (Dec 1991). "Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma". J Biol Chem 266 (32): 21833-8.
3. Tsai SP, Drayna D (Dec 1992). "The gene encoding human plasma carboxypeptidase B (CPB2) resides on chromosome 13". Genomics14 (2): 549-50.

Other Notes

Small volumes of anti-CPB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CPB2 purchase

MBS178498 is an antibody targeting CPB2. Reactive in Mouse
No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CPB2. It may not necessarily be applicable to this product.

NCBI GI #

31982712

NCBI GeneID

56373

NCBI Accession #

NP_062749.2

UniProt Primary Accession #

Q9JHH6

UniProt Secondary Accession #

Q5EBI3; Q9QZF0

UniProt Related Accession #

Q9JHH6

GenBank Nucleotide #

NM_019775.3

NCBI Official Full Name

carboxypeptidase B2 preproprotein

NCBI Official Synonym Full Names

carboxypeptidase B2 (plasma)

NCBI Official Symbol

Cpb2

NCBI Official Synonym Symbols

CPR; Cpu; TAFI; AI255929; 1110032P04Rik; 4930405E17Rik

UniProt Protein Name

Carboxypeptidase B2

UniProt Synonym Protein Names

Carboxypeptidase R; CPR; Carboxypeptidase U; CPU; Thrombin-activable fibrinolysis inhibitor; TAFI

Protein Family

Carboxypeptidase

UniProt Gene Name

Cpb2

UniProt Synonym Gene Names

Tafi; CPR; CPU; TAFI

UniProt Entry Name

CBPB2_MOUSE

NCBI Protein Information

carboxypeptidase B2

NCBI Summary for CPB2

This gene encodes carboxypeptidase B, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme, and secreted into plasma. [provided by RefSeq, Jan 2016]

UniProt Comments for CPB2

CPB2: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; EC 3.4.17.20; Secreted; Protease

Cellular Component: extracellular space

Molecular Function: carboxypeptidase activity; metallocarboxypeptidase activity

Biological Process: fibrinolysis; negative regulation of fibrinolysis; proteolysis; response to heat

Research Articles on CPB2

1. Carboxypeptidase B2 deficiency reveals that complement C3a limits infection and C5a exacerbates infection in a murine polymicrobial sepsis model.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CPB2 antibody

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Pancreatic Secretion Pathway antibodies	Pancreatic Secretion Pathway Diagram
Pancreatic Secretion Pathway antibodies	Pancreatic Secretion Pathway Diagram
Protein Digestion And Absorption Pathway antibodies	Protein Digestion And Absorption Pathway Diagram
Protein Digestion And Absorption Pathway antibodies	Protein Digestion And Absorption Pathway Diagram

Diseases associated with anti-CPB2 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>17 publications with CPB2 and Inflammation
Cardiovascular Diseases Antibodies	>13 publications with CPB2 and Cardiovascular Diseases
Necrosis Antibodies	>13 publications with CPB2 and Necrosis
Vascular Diseases Antibodies	>10 publications with CPB2 and Vascular Diseases
Liver Diseases Antibodies	>5 publications with CPB2 and Liver Diseases
Carcinoma Antibodies	>4 publications with CPB2 and Carcinoma
Edema Antibodies	>3 publications with CPB2 and Edema
Hepatitis Antibodies	>3 publications with CPB2 and Hepatitis
Carcinoma, Hepatocellular Antibodies	>2 publications with CPB2 and Carcinoma, Hepatocellular
Atherosclerosis Antibodies	>2 publications with CPB2 and Atherosclerosis

Organs/Tissues associated with anti-CPB2 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>15 publications with CPB2 and Liver
Muscle Antibodies	>4 publications with CPB2 and Muscle
Lung Antibodies	>2 publications with CPB2 and Lung
Testis Antibodies	>1 publications with CPB2 and Testis
Embryonic Tissue Antibodies	>1 publications with CPB2 and Embryonic Tissue