Rabbit Anti-ABCC4 Polyclonal Antibody – Cat# MBS178651

Western blot analysis of MRP4 expression in COLO320 whole cell lysates. MRP4 at 190KD was detected using rabbit anti- MRP4 Antigen Affinity purified polyclonal antibody at 0.5ug/mL. The blot was developed using chemiluminescence (ECL) method.

ABCC4 Antibody – Rabbit Polyclonal

Name: ABCC4 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178651
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178651

Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4(ABCC4) detection.Background: ABCC4(Atp-binding cassette, subfamily c, member 4), also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MRP4 (ABCC4), Polyclonal Antibody

Full Product Name

Anti-MRP4 Antibody

Product Gene Name

anti-ABCC4 antibody

Product Synonym Names

ABCC4; MOATB; MOAT-B; MRP4; O15439; Multidrug resistance-associated protein 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Lyophilized
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

88,138 Da

OMIM

AF071202 mRNA

3D Structure

ModBase 3D Structure for O15439

Notes

Tested Species: In-house tested species with positive results.
Other applications have not been tested.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Immunogen

E Coli-derived human MRP4 recombinant protein (Position: M1-K77).

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-ABCC4 antibody

Western Blot (WB)

Application Notes for anti-ABCC4 antibody

Western Blot: 0.1-0.5ug/ml

Product References and Citations for anti-ABCC4 antibody

1. Kool, M., de Haas, M., Scheffer, G. L., Scheper, R. J., van Eijk, M. J., Juijn, J. A., Baas, F., Borst, P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 57: 3537-3547, 1997.
2. Lee, K., Belinsky, M. G., Bell, D. W., Testa, J. R., Kruh, G. D. Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. Cancer Res. 58: 2741-2747, 1998.
3. van de Ven, R., Scheffer, G. L., Reurs, A. W., Lindenberg, J. J., Oerlemans, R., Jansen, G., Gillet, J.-P., Glasgow, J. N., Pereboev, A., Curiel, D. T., Scheper, R. J., de Gruijl, T. D. A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration.Blood 112: 2353-2359, 2008.

Other Notes

Small volumes of anti-ABCC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ABCC4 purchase

MBS178651 is an antibody targeting ABCC4. Also known as Anti-MRP4 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ABCC4. It may not necessarily be applicable to this product.

NCBI GI #

157502203

NCBI GeneID

10257

NCBI Accession #

NP_001098985.1

UniProt Primary Accession #

O15439

UniProt Secondary Accession #

Q8IVZ4; Q8IZN6; Q8NEW8; Q9Y6J2; A9Z1Z7; B7Z3Q7

UniProt Related Accession #

O15439

GenBank Nucleotide #

NM_001105515.2

NCBI Official Full Name

multidrug resistance-associated protein 4 isoform 2

NCBI Official Synonym Full Names

ATP binding cassette subfamily C member 4

NCBI Official Symbol

ABCC4

NCBI Official Synonym Symbols

MRP4; MOATB; MOAT-B

UniProt Protein Name

Multidrug resistance-associated protein 4

UniProt Synonym Protein Names

ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B

Protein Family

ABC transporter C family

UniProt Gene Name

ABCC4

UniProt Synonym Gene Names

MRP4; MOAT-B

NCBI Protein Information

multidrug resistance-associated protein 4

NCBI Summary for ABCC4

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

UniProt Comments for ABCC4

ABCC4: a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 13q32.1

Cellular Component: basolateral plasma membrane; membrane; plasma membrane; platelet dense granule membrane

Molecular Function: anion transmembrane-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

Biological Process: platelet degranulation; prostaglandin secretion; transmembrane transport

Research Articles on ABCC4

1. The tagSNP ABCC4 rs17268122 appears to be a prognostic factor in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) and surgery, independently of response to nCRT

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ABCC4 antibody

Reference Product	PubMed Publications
SLC22A6 antibody	>12 publications with ABCC4 and SLC22A6
SLC22A8 antibody	>10 publications with ABCC4 and SLC22A8
SLCO1B1 antibody	>8 publications with ABCC4 and SLCO1B1
SLCO1A2 antibody	>5 publications with ABCC4 and SLCO1A2
SNX27 antibody	>2 publications with ABCC4 and SNX27
ABCG4 antibody	>1 publications with ABCC4 and ABCG4

Pathways associated with anti-ABCC4 antibody

Products by Pathway	Pathway Diagram
ABC Transporters Pathway antibodies	ABC Transporters Pathway Diagram
ABC Transporters Pathway antibodies	ABC Transporters Pathway Diagram
ABC-family Proteins Mediated Transport Pathway antibodies	ABC-family Proteins Mediated Transport Pathway Diagram
Antifolate Resistance Pathway antibodies	Antifolate Resistance Pathway Diagram
Antifolate Resistance Pathway antibodies	Antifolate Resistance Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Drug Induction Of Bile Acid Pathway antibodies	Drug Induction Of Bile Acid Pathway Diagram
Ectoderm Differentiation Pathway antibodies	Ectoderm Differentiation Pathway Diagram
Fluoropyrimidine Activity Pathway antibodies	Fluoropyrimidine Activity Pathway Diagram

Diseases associated with anti-ABCC4 antibody

Disease Name	Pubmed Publications
Cholestasis Antibodies	>28 publications with ABCC4 and Cholestasis
Liver Diseases Antibodies	>26 publications with ABCC4 and Liver Diseases
Inflammation Antibodies	>25 publications with ABCC4 and Inflammation
Disease Models, Animal Antibodies	>19 publications with ABCC4 and Disease Models, Animal
Kidney Diseases Antibodies	>15 publications with ABCC4 and Kidney Diseases
Fibrosis Antibodies	>14 publications with ABCC4 and Fibrosis
Drug-Induced Liver Injury Antibodies	>13 publications with ABCC4 and Drug-Induced Liver Injury
Colorectal Neoplasms Antibodies	>13 publications with ABCC4 and Colorectal Neoplasms
Necrosis Antibodies	>12 publications with ABCC4 and Necrosis
Brain Diseases Antibodies	>12 publications with ABCC4 and Brain Diseases

Organs/Tissues associated with anti-ABCC4 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>133 publications with ABCC4 and Blood
Liver Antibodies	>96 publications with ABCC4 and Liver
Kidney Antibodies	>93 publications with ABCC4 and Kidney
Brain Antibodies	>53 publications with ABCC4 and Brain
Lung Antibodies	>28 publications with ABCC4 and Lung
Vascular Antibodies	>27 publications with ABCC4 and Vascular
Intestine Antibodies	>25 publications with ABCC4 and Intestine
Muscle Antibodies	>19 publications with ABCC4 and Muscle
Prostate Antibodies	>12 publications with ABCC4 and Prostate
Eye Antibodies	>11 publications with ABCC4 and Eye