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IRF9 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178689

Rabbit IgG polyclonal antibody for Interferon regulatory factor 9 (IRF9) detection.Background: Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G. It is mapped to 14q1. IRF9 is a 48 kDa member of… More details

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Product Overview

Online Datasheet in PDF
Product Name
IRF9, Polyclonal Antibody
Full Product Name
Anti-IRF9 Antibody
Product Gene Name
anti-IRF9 antibody
Product Synonym Names
IRF9; IRF-9; IRF 9; ISGF 3 gamma; ISGF-3 gamma; ISGF3; ISGF3 p48 subunit; ISGF3G; p48; Q00978; Interferon regulatory factor 9
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
43,696 Da
OMIM
M87503 mRNA
3D Structure
ModBase 3D Structure for Q00978
Notes
Tested Species: In-house tested species with positive results.
Other applications have not been tested.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Immunogen
E. coli-derived human IRF9 recombinant protein (Position: M1-K110). Human IRF9 shares 87.3% amino acid (aa) sequence identity with mouse IRF9.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-IRF9 antibody
Western Blot (WB)
Application Notes for anti-IRF9 antibody
Western Blot: 0.1-0.5ug/ml

Western Blot (WB) of anti-IRF9 antibody

Western blot analysis of IRF9 expression in U87 whole cell lysates (lane 1). IRF9 at 44KD was detected using rabbit anti- IRF9 Antigen Affinity purified polyclonal antibody at 0.5ug/mL. The blot was developed using chemiluminescence (ECL) method.
Rabbit Anti-IRF9 Polyclonal Antibody – Cat# MBS178689

Product References and Citations for anti-IRF9 antibody

1. Fu, X.-Y., Kessler, D. S., Veals, S. A., Levy, D. E., Darnell, J. E., Jr. ISGF3, the transcriptional activator induced by interferon alpha consists of multiple interacting polypeptide chains. Proc. Nat. Acad. Sci. 87: 8555-8559, 1990.
2. Levy, D. E., Kessler, D. S., Pine, R., Darnell, J. E., Jr. Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.
3. Suhara, W., Yoneyama, M., Yonekawa, H., Fujita, T. Structure of mouse interferon stimulated gene factor 3 gamma (ISGF3 gamma/p48) cDNA and chromosomal localization of the gene. J. Biochem. 119: 231-234, 1996.

Other Notes

Small volumes of anti-IRF9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IRF9 purchase

MBS178689 is an antibody targeting IRF9. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IRF9. It may not necessarily be applicable to this product.

NCBI GI #
25282407
NCBI GeneID
10379
NCBI Accession #
NP_006075.3
UniProt Primary Accession #
Q00978
UniProt Secondary Accession #
D3DS61
UniProt Related Accession #
Q00978
GenBank Nucleotide #
NM_006084.4
NCBI Official Full Name
interferon regulatory factor 9
NCBI Official Synonym Full Names
interferon regulatory factor 9
NCBI Official Symbol
IRF9
NCBI Official Synonym Symbols
p48; IRF-9; ISGF3; ISGF3G
UniProt Protein Name
Interferon regulatory factor 9
UniProt Synonym Protein Names
IFN-alpha-responsive transcription factor subunit; ISGF3 p48 subunit; Interferon-stimulated gene factor 3 gamma; ISGF-3 gamma; Transcriptional regulator ISGF3 subunit gamma
Protein Family
Interferon regulatory factor
UniProt Gene Name
IRF9
UniProt Synonym Gene Names
ISGF3G; IRF-9; ISGF-3 gamma
NCBI Protein Information
interferon regulatory factor 9

UniProt Comments for IRF9

IRF9: Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Belongs to the IRF family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: cell surface receptor linked signal transduction; transcription from RNA polymerase II promoter
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Research Articles on IRF9

1. Interferonstimulated gene factor 3 complex, which consists of STAT1, STAT2 and IRF9, is required for the induction of SAMHD1 expression by IFN-alpha in SMMC-7721 cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IRF9 antibody

 Reference Product  PubMed Publications
 STAT1 antibody  >192 publications with IRF9 and STAT1
 STAT2 antibody  >147 publications with IRF9 and STAT2
 IRF1 antibody  >57 publications with IRF9 and IRF1
 JAK1 antibody  >40 publications with IRF9 and JAK1
 TYK2 antibody  >25 publications with IRF9 and TYK2
 ISG15 antibody  >14 publications with IRF9 and ISG15
 MX1 antibody  >9 publications with IRF9 and MX1
 IFNAR2 antibody  >8 publications with IRF9 and IFNAR2
 ISG20 antibody  >1 publications with IRF9 and ISG20
 CREBBP antibody  >1 publications with IRF9 and CREBBP

Pathways associated with anti-IRF9 antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 IFN-gamma Pathway antibodies  IFN-gamma Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram

Diseases associated with anti-IRF9 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >25 publications with IRF9 and Inflammation
 Liver Diseases Antibodies  >23 publications with IRF9 and Liver Diseases
 Necrosis Antibodies  >15 publications with IRF9 and Necrosis
 Disease Models, Animal Antibodies  >10 publications with IRF9 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >10 publications with IRF9 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >8 publications with IRF9 and Carcinoma, Hepatocellular
 Brain Diseases Antibodies  >7 publications with IRF9 and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >6 publications with IRF9 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >5 publications with IRF9 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >4 publications with IRF9 and Kidney Diseases

Organs/Tissues associated with anti-IRF9 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >49 publications with IRF9 and Blood
 Liver Antibodies  >26 publications with IRF9 and Liver
 Muscle Antibodies  >8 publications with IRF9 and Muscle
 Kidney Antibodies  >8 publications with IRF9 and Kidney
 Skin Antibodies  >8 publications with IRF9 and Skin
 Brain Antibodies  >8 publications with IRF9 and Brain
 Lung Antibodies  >7 publications with IRF9 and Lung
 Spleen Antibodies  >7 publications with IRF9 and Spleen
 Vascular Antibodies  >6 publications with IRF9 and Vascular
 Heart Antibodies  >5 publications with IRF9 and Heart
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