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Lipoprotein Lipase (LPL) Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS179259

Anti-Lipoprotein lipase LPL Rabbit Monoclonal Antibody catalog # MBS179259. Tested in IHC, WB applications. This antibody reacts with Human. More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lipoprotein lipase (LPL), Monoclonal Antibody
Full Product Name
Anti-Lipoprotein lipase Rabbit Monoclonal Antibody
Product Gene Name
anti-LPL antibody
Product Synonym Names
Lipoprotein lipase; LPL; 3.1.1.34; LPL; LIPD
Clonality
Monoclonal
Isotype
IgG
Clone Number
ABDE-12
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity-chromatography
Concentration
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. (lot specific)
Preparation and Storage
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
OMIM
M15856 mRNA
3D Structure
ModBase 3D Structure for P06858
Conjugate
No
Immunogen
A synthesized peptide derived from human Lipoprotein lipase

Product Categories/Family for anti-LPL antibody

Cardiovascular; Lipids/Lipoproteins; Lipid Metabolism; Lipases; Signal Transduction; Stem Cells; Mesenchymal Stem Cells; Adipogenesis; Cancer; Cancer Metabolism; Metabolic Signaling Pathway; Metabolism of Lipids and Lipoproteins; Metabolism; Pathways and
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-LPL antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-LPL antibody
Dilute the sample so that the expected range of concentrations fall within the detection range of this kit. If the expected range of concentration is unknown, a pilot test should be conducted to decide the optimal dilution ratio for your samples. Some PubMed article(s) citing the expression level of this target are as follows: Internal QC testing used
WB: 1:1000-1:5000
IHC: 1:50-1:200

Western Blot (WB) of anti-LPL antibody

Western blot analysis of Lipoprotein lipase expression in Human fetal liver lysate (MBS179259).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-LPL monoclonal antibody overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for LPL
Rabbit Anti-LPL Monoclonal Antibody – Cat# MBS179259

Other Notes

Small volumes of anti-LPL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LPL purchase

MBS179259 is an antibody targeting LPL. Also known as Anti-Lipoprotein lipase Rabbit Monoclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LPL. It may not necessarily be applicable to this product.

NCBI GI #
4557727
NCBI GeneID
4023
NCBI Accession #
NP_000228.1
UniProt Primary Accession #
P06858
UniProt Secondary Accession #
Q16282; Q16283; Q96FC4; B2R5T9
UniProt Related Accession #
P06858
GenBank Nucleotide #
NM_000237.2
NCBI Official Full Name
lipoprotein lipase
NCBI Official Synonym Full Names
lipoprotein lipase
NCBI Official Symbol
LPL
NCBI Official Synonym Symbols
LIPD; HDLCQ11
UniProt Protein Name
Lipoprotein lipase
Protein Family
Lipoprotein
UniProt Gene Name
LPL
UniProt Synonym Gene Names
LIPD; LPL
NCBI Protein Information
lipoprotein lipase

NCBI Summary for LPL

LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
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UniProt Comments for LPL

The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL) (PubMed:27578112). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium ().
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Research Articles on LPL

1. ANGPTL8 has a functional LPL inhibitory motif, but only inhibits LPL and increases plasma TG levels in mice in the presence of ANGPTL3

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LPL antibody

 Reference Product  PubMed Publications
 APOE antibody  >302 publications with LPL and APOE
 APOB antibody  >228 publications with LPL and APOB
 APOC2 antibody  >167 publications with LPL and APOC2
 FABP4 antibody  >51 publications with LPL and FABP4
 APOC3 antibody  >46 publications with LPL and APOC3
 APOA1 antibody  >30 publications with LPL and APOA1
 LIPE antibody  >7 publications with LPL and LIPE
 INS antibody  >7 publications with LPL and INS
 LRP1 antibody  >6 publications with LPL and LRP1
 APOA2 antibody  >4 publications with LPL and APOA2

Pathways associated with anti-LPL antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram

Diseases associated with anti-LPL antibody

 Disease Name  Pubmed Publications
 Dyslipidemias Antibodies  >709 publications with LPL and Dyslipidemias
 Hyperlipidemias Antibodies  >673 publications with LPL and Hyperlipidemias
 Cardiovascular Diseases Antibodies  >609 publications with LPL and Cardiovascular Diseases
 Hypertriglyceridemia Antibodies  >513 publications with LPL and Hypertriglyceridemia
 Atherosclerosis Antibodies  >475 publications with LPL and Atherosclerosis
 Obesity Antibodies  >430 publications with LPL and Obesity
 Fatty Liver Antibodies  >276 publications with LPL and Fatty Liver
 Heart Diseases Antibodies  >271 publications with LPL and Heart Diseases
 Necrosis Antibodies  >162 publications with LPL and Necrosis
 Inflammation Antibodies  >138 publications with LPL and Inflammation

Organs/Tissues associated with anti-LPL antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2288 publications with LPL and Blood
 Adipose Tissue Antibodies  >1199 publications with LPL and Adipose Tissue
 Connective Tissue Antibodies  >903 publications with LPL and Connective Tissue
 Liver Antibodies  >837 publications with LPL and Liver
 Muscle Antibodies  >783 publications with LPL and Muscle
 Heart Antibodies  >606 publications with LPL and Heart
 Vascular Antibodies  >387 publications with LPL and Vascular
 Intestine Antibodies  >215 publications with LPL and Intestine
 Kidney Antibodies  >152 publications with LPL and Kidney
 Bone Antibodies  >152 publications with LPL and Bone
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