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HMGCR Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS179402

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HMGCR/Hmg Coa Reductase, Monoclonal Antibody
Full Product Name
Anti-HMGCR/Hmg Coa Reductase Rabbit Monoclonal Antibody
Product Gene Name
anti-HMGCR antibody
Product Synonym Names
3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; 1.1.1.34; HMGCR
Clonality
Monoclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity-chromatography
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
97476 MW
OMIM
M11058 mRNA
3D Structure
ModBase 3D Structure for P04035
Immunogen
A synthesized peptide derived from human HMGCR
Subcellular Localization
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Product Categories/Family for anti-HMGCR antibody

Cardiovascular; Lipids/Lipoproteins; Lipid Metabolism; Cholesterol Metabolism; Signal Transduction; Cardiovascular; Atherosclerosis; Lipoprotein Metabolism; Cancer; Cancer Metabolism; Metabolic Signaling Pathway; Metabolism of Lipids and Lipoproteins; Met
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-HMGCR antibody
Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-HMGCR antibody
WB: 1:500-1:2000
IP: 1:50

Western Blot (WB) of anti-HMGCR antibody

Western blot analysis of HMGCR expression in Jurkat cell lysate (MBS179402).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-HMGCR monoclonal antibody overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for HMGCR
Rabbit Anti-HMGCR Monoclonal Antibody – Cat# MBS179402

Other Notes

Small volumes of anti-HMGCR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HMGCR purchase

MBS179402 is an antibody targeting HMGCR. Also known as Anti-HMGCR/Hmg Coa Reductase Rabbit Monoclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HMGCR. It may not necessarily be applicable to this product.

NCBI GI #
4557643
NCBI GeneID
3156
NCBI Accession #
NP_000850.1
UniProt Primary Accession #
P04035
UniProt Secondary Accession #
Q8N190; B7Z3Y9
UniProt Related Accession #
P04035
GenBank Nucleotide #
NM_000859.2
NCBI Official Full Name
3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1
NCBI Official Synonym Full Names
3-hydroxy-3-methylglutaryl-CoA reductase
NCBI Official Symbol
HMGCR
NCBI Official Synonym Symbols
LDLCQ3
UniProt Protein Name
3-hydroxy-3-methylglutaryl-coenzyme A reductase
UniProt Gene Name
HMGCR
UniProt Synonym Gene Names
HMG-CoA reductase
NCBI Protein Information
3-hydroxy-3-methylglutaryl-Coenzyme A reductase

NCBI Summary for HMGCR

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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Research Articles on HMGCR

1. HMGCR genetic variation is associated with Alzheimer's disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HMGCR antibody

 Reference Product  PubMed Publications
 SREBF2 antibody  >25 publications with HMGCR and SREBF2
 HMGCS1 antibody  >16 publications with HMGCR and HMGCS1
 SQLE antibody  >8 publications with HMGCR and SQLE
 INSIG1 antibody  >5 publications with HMGCR and INSIG1
 MVK antibody  >4 publications with HMGCR and MVK
 SC4MOL antibody  >2 publications with HMGCR and SC4MOL
 PPARA antibody  >2 publications with HMGCR and PPARA
 CREBBP antibody  >1 publications with HMGCR and CREBBP
 HMGCS2 antibody  >1 publications with HMGCR and HMGCS2
 UBC antibody  >1 publications with HMGCR and UBC

Pathways associated with anti-HMGCR antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram

Diseases associated with anti-HMGCR antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >57 publications with HMGCR and Cardiovascular Diseases
 Fatty Liver Antibodies  >47 publications with HMGCR and Fatty Liver
 Dyslipidemias Antibodies  >41 publications with HMGCR and Dyslipidemias
 Atherosclerosis Antibodies  >39 publications with HMGCR and Atherosclerosis
 Hypercholesterolemia Antibodies  >39 publications with HMGCR and Hypercholesterolemia
 Nervous System Diseases Antibodies  >38 publications with HMGCR and Nervous System Diseases
 Liver Diseases Antibodies  >36 publications with HMGCR and Liver Diseases
 Hyperlipidemias Antibodies  >34 publications with HMGCR and Hyperlipidemias
 Inflammation Antibodies  >26 publications with HMGCR and Inflammation
 Heart Diseases Antibodies  >25 publications with HMGCR and Heart Diseases

Organs/Tissues associated with anti-HMGCR antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >158 publications with HMGCR and Liver
 Blood Antibodies  >151 publications with HMGCR and Blood
 Heart Antibodies  >31 publications with HMGCR and Heart
 Brain Antibodies  >31 publications with HMGCR and Brain
 Muscle Antibodies  >30 publications with HMGCR and Muscle
 Kidney Antibodies  >25 publications with HMGCR and Kidney
 Vascular Antibodies  >22 publications with HMGCR and Vascular
 Ovary Antibodies  >16 publications with HMGCR and Ovary
 Intestine Antibodies  >11 publications with HMGCR and Intestine
 Nerve Antibodies  >8 publications with HMGCR and Nerve
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