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CD62P Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS179604

Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of… More details

$210 / 0.03 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD62P, Monoclonal Antibody
Full Product Name
Anti-CD62P Rabbit Monoclonal Antibody
Product Gene Name
anti-CD62P antibody
Product Synonym Gene Name
SELP
Product Synonym Names
P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P; SELP; GMRP; GRMP
Clonality
Monoclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Affinity-chromatography
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
90834 MW
3D Structure
ModBase 3D Structure for P16109
Immunogen
A synthesized peptide derived from human CD62P
Subcellular Localization
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CD62P antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-CD62P antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-CD62P antibody

Western blot analysis of CD62P expression in HUVEC cell lysate (MBS179604).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-SELP monoclonal antibody overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for SELP
Rabbit Anti-CD62P Monoclonal Antibody – Cat# MBS179604

Other Notes

Small volumes of anti-CD62P antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD62P purchase

MBS179604 is an antibody targeting CD62P. Also known as Anti-CD62P Rabbit Monoclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD62P. It may not necessarily be applicable to this product.

NCBI GI #
157419154
NCBI GeneID
6403
NCBI Accession #
NP_002996.2
UniProt Primary Accession #
P16109
UniProt Secondary Accession #
Q5R344; Q8IVD1
UniProt Related Accession #
P16109
GenBank Nucleotide #
NM_003005.3
NCBI Official Full Name
P-selectin
NCBI Official Synonym Full Names
selectin P
NCBI Official Symbol
SELP
NCBI Official Synonym Symbols
CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM
UniProt Protein Name
P-selectin
UniProt Synonym Protein Names
CD62 antigen-like family member P; Granule membrane protein 140; GMP-140
Protein Family
P-selectin
UniProt Gene Name
SELP
UniProt Synonym Gene Names
GMRP; GRMP; LECAM3; PADGEM
NCBI Protein Information
P-selectin

NCBI Summary for CD62P

This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD62P

Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.
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Research Articles on CD62P

1. coronary thrombi in STEMI patients resistant to fibrinolysis are characterised by higher fibrin, P-selectin and VWF content than lysis-sensitive thrombi

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD62P antibody

 Reference Product  PubMed Publications
 CRP antibody  >5 publications with CD62P and CRP
 SELPLG antibody  >5 publications with CD62P and SELPLG
 ITGAM antibody  >3 publications with CD62P and ITGAM
 STAT6 antibody  >2 publications with CD62P and STAT6
 ITGB2 antibody  >1 publications with CD62P and ITGB2
 CD63 antibody  >1 publications with CD62P and CD63

Pathways associated with anti-CD62P antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram

Diseases associated with anti-CD62P antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >52 publications with CD62P and Cardiovascular Diseases
 Inflammation Antibodies  >29 publications with CD62P and Inflammation
 Heart Diseases Antibodies  >21 publications with CD62P and Heart Diseases
 Atherosclerosis Antibodies  >19 publications with CD62P and Atherosclerosis
 Myocardial Ischemia Antibodies  >19 publications with CD62P and Myocardial Ischemia
 Coronary Artery Disease Antibodies  >18 publications with CD62P and Coronary Artery Disease
 Neoplasms Antibodies  >17 publications with CD62P and Neoplasms
 Thrombosis Antibodies  >12 publications with CD62P and Thrombosis
 Necrosis Antibodies  >8 publications with CD62P and Necrosis
 Myocardial Infarction Antibodies  >6 publications with CD62P and Myocardial Infarction

Organs/Tissues associated with anti-CD62P antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >90 publications with CD62P and Blood
 Vascular Antibodies  >41 publications with CD62P and Vascular
 Brain Antibodies  >14 publications with CD62P and Brain
 Lung Antibodies  >10 publications with CD62P and Lung
 Muscle Antibodies  >8 publications with CD62P and Muscle
 Kidney Antibodies  >6 publications with CD62P and Kidney
 Bone Antibodies  >6 publications with CD62P and Bone
 Nerve Antibodies  >4 publications with CD62P and Nerve
 Testis Antibodies  >4 publications with CD62P and Testis
 Connective Tissue Antibodies  >3 publications with CD62P and Connective Tissue
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