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PSD95 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS179800

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory… More details

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Product Overview

Online Datasheet in PDF
Product Name
PSD95, Monoclonal Antibody
Full Product Name
Anti-PSD95 Rabbit Monoclonal Antibody
Product Gene Name
anti-PSD95 antibody
Product Synonym Gene Name
DLG4
Product Synonym Names
Disks large homolog 4; Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90; DLG4; PSD95
Clonality
Monoclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity-chromatography
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
80495 MW
OMIM
U83192 mRNA
3D Structure
ModBase 3D Structure for P78352
Immunogen
A synthesized peptide derived from human PSD95
Subcellular Localization
Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell junction, synapse. High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.
Tissue Specificity
Brain.
Contents
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-PSD95 antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB)
Application Notes for anti-PSD95 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:200
IP: 1:20
FC/FACS: 1:20

Western Blot (WB) of anti-PSD95 antibody

Western blot analysis of PSD95 expression in Mouse brain tissue lysate (MBS179800).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions.
After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-DLG4 monoclonal antibody overnight at 4 degree C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for DLG4
Rabbit Anti-PSD95 Monoclonal Antibody – Cat# MBS179800

Other Notes

Small volumes of anti-PSD95 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSD95 purchase

MBS179800 is an antibody targeting PSD95. Also known as Anti-PSD95 Rabbit Monoclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PSD95. It may not necessarily be applicable to this product.

NCBI GI #
192447426
NCBI GeneID
1742
NCBI Accession #
NP_001122299.1
UniProt Primary Accession #
P78352
UniProt Secondary Accession #
Q92941; Q9UKK8; B7Z1S1; G5E939
UniProt Related Accession #
P78352
GenBank Nucleotide #
NM_001128827.2
NCBI Official Full Name
disks large homolog 4 isoform 2
NCBI Official Synonym Full Names
discs large MAGUK scaffold protein 4
NCBI Official Symbol
DLG4
NCBI Official Synonym Symbols
PSD95; SAP90; SAP-90
UniProt Protein Name
Disks large homolog 4
UniProt Synonym Protein Names
Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90
UniProt Gene Name
DLG4
UniProt Synonym Gene Names
PSD95; PSD-95; SAP-90; SAP90
NCBI Protein Information
disks large homolog 4

NCBI Summary for PSD95

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for PSD95

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B ().
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Research Articles on PSD95

1. the authors integrate molecular and imaging data from animal models and preterm infants, and find that microglial expression of DLG4 plays a role.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PSD95 antibody

 Reference Product  PubMed Publications
 ERBB4 antibody  >3 publications with PSD95 and ERBB4
 CRIPT antibody  >2 publications with PSD95 and CRIPT
 GRIN2A antibody  >2 publications with PSD95 and GRIN2A
 GRIN1 antibody  >1 publications with PSD95 and GRIN1
 GRIN2B antibody  >1 publications with PSD95 and GRIN2B

Pathways associated with anti-PSD95 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Ca-permeable Kainate Receptor Pathway antibodies  Activation Of Ca-permeable Kainate Receptor Pathway Diagram
 Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies  Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram

Diseases associated with anti-PSD95 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >29 publications with PSD95 and Nervous System Diseases
 Brain Diseases Antibodies  >28 publications with PSD95 and Brain Diseases
 Death Antibodies  >9 publications with PSD95 and Death
 Drug Toxicity Antibodies  >7 publications with PSD95 and Drug Toxicity
 Substance-Related Disorders Antibodies  >7 publications with PSD95 and Substance-Related Disorders
 Movement Disorders Antibodies  >6 publications with PSD95 and Movement Disorders
 Cognition Disorders Antibodies  >5 publications with PSD95 and Cognition Disorders
 Pain Antibodies  >4 publications with PSD95 and Pain
 Learning Disorders Antibodies  >3 publications with PSD95 and Learning Disorders
 Child Development Disorders, Pervasive Antibodies  >3 publications with PSD95 and Child Development Disorders, Pervasive

Organs/Tissues associated with anti-PSD95 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >78 publications with PSD95 and Brain
 Muscle Antibodies  >7 publications with PSD95 and Muscle
 Kidney Antibodies  >5 publications with PSD95 and Kidney
 Embryonic Tissue Antibodies  >3 publications with PSD95 and Embryonic Tissue
 Eye Antibodies  >3 publications with PSD95 and Eye
 Skin Antibodies  >2 publications with PSD95 and Skin
 Lung Antibodies  >1 publications with PSD95 and Lung
 Testis Antibodies  >1 publications with PSD95 and Testis
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