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CD64 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800006

CD64 (FcgammaRI) is a cell surface receptor for Fc region of IgG. It is composed of specific ligand binding alpha subunit and promiscuous gamma subunit, which is indispensable for tyrosine-based signaling. However, even the alpha subunit can transduce signals… More details

$345 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD64, Monoclonal Antibody
Full Product Name
Anti-Hu CD64 Biotin
Product Gene Name
anti-CD64 antibody
Product Synonym Gene Name
FCGR1A
Product Synonym Names
Fc fragment of IgG receptor Ia; FcRI; IGFR1; FcgR1A
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
10.1
Host
Mouse
Species Reactivity
Human, Non-human primates
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purity/Purification
The purified antibody is conjugated with biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Concentration
1 mg/ml (lot specific)
Specificity
The mouse monoclonal antibody 10.1 recognizes an extracellular epitope on CD64/FcgammaRI, a 72 kDa single chain type I glycoprotein, that is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes.
Preparation and Storage
Store at 2-8 degree C.
Matching Pairs
Unconjugated Antibody: CD64 Clone #10.1 (MBS1800003)
Biotin Conjugated Antibody: CD64 Clone #10.1 (MBS1800006)
OMIM
146760
3D Structure
ModBase 3D Structure for P12314
Immunogen
Rheumatoid synovial fluid cells and fibronectin purified human monocytes
Conjugation
Biotin
Applications Tested/Suitable for anti-CD64 antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB), Immunohistochemistry (IHC) Frozen/Paraffin, Immunocytochemistry (ICC)
Application Notes for anti-CD64 antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-CD64 antibody

Separation of human monocytes (red-filled) from human lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of peripheral whole blood stained using anti-human CD64 (10.1) biotin antibody (concentration in sample 4 ug/ml, Streptavidin APC).
Mouse Anti-CD64 Monoclonal Antibody – Cat# MBS1800006

Flow Cytometry (FC/FACS) of anti-CD64 antibody

Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD64 (10.1) biotin antibody (concentration in sample 4 ug/ml, Streptavidin APC).
Mouse Anti-CD64 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1800006

Other Notes

Small volumes of anti-CD64 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD64 purchase

MBS1800006 is an antibody targeting CD64. Also known as Anti-Hu CD64 Biotin. Reactive in Human, Non-human primates. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD64. It may not necessarily be applicable to this product.

NCBI GI #
50403717
NCBI GeneID
2209
NCBI Accession #
P12314.2
UniProt Primary Accession #
P12314
UniProt Related Accession #
P12314
NCBI Official Full Name
High affinity immunoglobulin gamma Fc receptor I
NCBI Official Synonym Full Names
Fc fragment of IgG receptor Ia
NCBI Official Symbol
FCGR1A
NCBI Official Synonym Symbols
CD64; FCRI; CD64A; IGFR1
UniProt Protein Name
High affinity immunoglobulin gamma Fc receptor I
UniProt Synonym Protein Names
Fc-gamma RI; FcRI; Fc-gamma RIA; FcgammaRIa; CD_antigen: CD64
Protein Family
High affinity immunoglobulin gamma Fc receptor
UniProt Gene Name
FCGR1A
UniProt Synonym Gene Names
FCG1; FCGR1; IGFR1; IgG Fc receptor I; FcRI; FcgammaRIa
UniProt Entry Name
FCGR1_HUMAN
NCBI Protein Information
high affinity immunoglobulin gamma Fc receptor I

NCBI Summary for CD64

This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008]

UniProt Comments for CD64

FCGR1A: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Belongs to the immunoglobulin superfamily. FCGR1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21.2-q21.3

Cellular Component: early endosome membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; IgG binding; receptor signaling protein activity

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response; signal transduction; phagocytosis, engulfment
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Research Articles on CD64

1. binding by sTLT1 initiates inflammatory signals in macrophages

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD64 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway antibodies  Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-CD64 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >31 publications with CD64 and Inflammation
 Necrosis Antibodies  >15 publications with CD64 and Necrosis
 Cardiovascular Diseases Antibodies  >8 publications with CD64 and Cardiovascular Diseases
 Respiratory Tract Diseases Antibodies  >8 publications with CD64 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >6 publications with CD64 and Lung Diseases
 Hematologic Diseases Antibodies  >5 publications with CD64 and Hematologic Diseases
 Atherosclerosis Antibodies  >3 publications with CD64 and Atherosclerosis
 Disease Susceptibility Antibodies  >3 publications with CD64 and Disease Susceptibility
 Asthma Antibodies  >3 publications with CD64 and Asthma
 Carcinoma Antibodies  >2 publications with CD64 and Carcinoma

Organs/Tissues associated with anti-CD64 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >78 publications with CD64 and Blood
 Lung Antibodies  >5 publications with CD64 and Lung
 Vascular Antibodies  >4 publications with CD64 and Vascular
 Kidney Antibodies  >3 publications with CD64 and Kidney
 Intestine Antibodies  >2 publications with CD64 and Intestine
 Stomach Antibodies  >1 publications with CD64 and Stomach
 Brain Antibodies  >1 publications with CD64 and Brain
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