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CD100 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800037

CD100, also known as Semaphorin 4D, is a homodimerizing type I transmembrane glycoprotein containing an extracellular semaphorin domain. It is expressed on most hematopoietic cells with the exception of immature bone marrow cells, erythrocytes and platelets.… More details

$295 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD100, Monoclonal Antibody
Full Product Name
Anti-Hu CD100 Purified
Product Gene Name
anti-CD100 antibody
Product Synonym Gene Name
SEMA4D
Product Synonym Names
semaphorin 4D; COLL4; SEMA4D; semaphorin 4D
Clonality
Monoclonal
Isotype
IgM
Clone Number
133-1C6
Host
Mouse
Species Reactivity
Human
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purity/Purification
Purified by Protein-A Affinity Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
The mouse monoclonal antibody 133-1C6 recognizes an extracellular epitope of CD100, an approximately 150 kDa (when reduced) semaphorin family member expressed mainly on lymphocytes, NK cells, monocytes/macrophages and granulocytes, but also on some non-hematopoietic cells.
Preparation and Storage
Store at 2-8 degree C.
Matching Pairs
Unconjugated Antibody: CD100 Clone #133-1C6 (MBS1800037)
PE Conjugated Antibody: CD100 Clone #133-1C6 (MBS1800038)
OMIM
601866
3D Structure
ModBase 3D Structure for Q92854
Immunogen
PHA stimulated human PBL
Applications Tested/Suitable for anti-CD100 antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), ELISA (EIA)
Application Notes for anti-CD100 antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-CD100 antibody

Flow cytometry analysis (surface staining) of human peripheral blood with anti-CD100 (133-1C6) purified, GAM-APC.
Mouse Anti-CD100 Monoclonal Antibody – Cat# MBS1800037

Other Notes

Small volumes of anti-CD100 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD100 purchase

MBS1800037 is an antibody targeting CD100. Also known as Anti-Hu CD100 Purified. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD100. It may not necessarily be applicable to this product.

NCBI GI #
214010218
NCBI GeneID
10507
NCBI Accession #
NP_006369.3
UniProt Primary Accession #
Q92854
UniProt Related Accession #
Q92854
GenBank Nucleotide #
NP_006369.3
NCBI Official Full Name
semaphorin-4D isoform 1
NCBI Official Synonym Full Names
semaphorin 4D
NCBI Official Symbol
SEMA4D
NCBI Official Synonym Symbols
A8; GR3; BB18; CD100; COLL4; SEMAJ; coll-4; C9orf164; M-sema-G
UniProt Protein Name
Semaphorin-4D
UniProt Synonym Protein Names
A8; BB18; GR3
Protein Family
Semaphorin
UniProt Gene Name
SEMA4D
UniProt Synonym Gene Names
C9orf164; CD100; SEMAJ
UniProt Entry Name
SEM4D_HUMAN
NCBI Protein Information
semaphorin-4D

UniProt Comments for CD100

SEMA4D: a single-pass type I membrane protein that my play a functional role in the immune system, as well as in the nervous system. Induces B-cells to aggregate and improves their viability in vitro.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q22.2

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; transmembrane receptor activity; receptor activity; semaphorin receptor binding; receptor binding

Biological Process: axon guidance; negative regulation of peptidyl-tyrosine phosphorylation; regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell adhesion; positive regulation of phosphoinositide 3-kinase cascade; regulation of cell shape; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of osteoblast differentiation; immune response; positive regulation of protein amino acid phosphorylation; cell adhesion; positive regulation of collateral sprouting; regulation of cell projection organization and biogenesis; negative regulation of apoptosis; positive regulation of cell migration
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Research Articles on CD100

1. Sema4D and 4A seem to play a critical role in the pathogenesis of some autoimmune diseases, such as multiple sclerosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD100 antibody

 Reference Product  PubMed Publications
 PLXNB1 antibody  >57 publications with CD100 and PLXNB1
 CD72 antibody  >31 publications with CD100 and CD72
 MET antibody  >17 publications with CD100 and MET
 ERBB2 antibody  >6 publications with CD100 and ERBB2
 PTPRC antibody  >5 publications with CD100 and PTPRC
 RND1 antibody  >4 publications with CD100 and RND1
 RRAS antibody  >3 publications with CD100 and RRAS
 ARHGEF12 antibody  >2 publications with CD100 and ARHGEF12
 ARHGEF11 antibody  >2 publications with CD100 and ARHGEF11
 GRLF1 antibody  >1 publications with CD100 and GRLF1

Pathways associated with anti-CD100 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Other Semaphorin Interactions Pathway antibodies  Other Semaphorin Interactions Pathway Diagram
 Sema4D In Semaphorin Signaling Pathway antibodies  Sema4D In Semaphorin Signaling Pathway Diagram
 Sema4D Induced Cell Migration And Growth-cone Collapse Pathway antibodies  Sema4D Induced Cell Migration And Growth-cone Collapse Pathway Diagram
 Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway antibodies  Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram

Diseases associated with anti-CD100 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >31 publications with CD100 and Neoplasms
 Nervous System Diseases Antibodies  >19 publications with CD100 and Nervous System Diseases
 Brain Diseases Antibodies  >9 publications with CD100 and Brain Diseases
 Inflammation Antibodies  >8 publications with CD100 and Inflammation
 Disease Models, Animal Antibodies  >6 publications with CD100 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >6 publications with CD100 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >4 publications with CD100 and Kidney Diseases
 Necrosis Antibodies  >3 publications with CD100 and Necrosis
 Nerve Degeneration Antibodies  >2 publications with CD100 and Nerve Degeneration
 Cerebral Infarction Antibodies  >2 publications with CD100 and Cerebral Infarction

Organs/Tissues associated with anti-CD100 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >83 publications with CD100 and Nerve
 Blood Antibodies  >64 publications with CD100 and Blood
 Brain Antibodies  >22 publications with CD100 and Brain
 Embryonic Tissue Antibodies  >15 publications with CD100 and Embryonic Tissue
 Kidney Antibodies  >7 publications with CD100 and Kidney
 Skin Antibodies  >5 publications with CD100 and Skin
 Lymph Node Antibodies  >5 publications with CD100 and Lymph Node
 Lung Antibodies  >4 publications with CD100 and Lung
 Bone Marrow Antibodies  >4 publications with CD100 and Bone Marrow
 Spinal Cord Antibodies  >4 publications with CD100 and Spinal Cord
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