• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CD314 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800077

CD314, also known as NKG2D (natural killer receptor G2D) or KLRK1 (killer cell lectin-like receptor subfamily K, member 1), is a homodimeric C-type lectin-like activating receptor and costimulator with type II membrane orientation (C teminus extracellular).… More details

$295 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD314, Monoclonal Antibody
Full Product Name
Anti-Hu CD314 Purified
Product Gene Name
anti-CD314 antibody
Product Synonym Gene Name
KLRK1
Product Synonym Names
killer cell lectin like receptor K1; NKG2D; KLRK1; KLR
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
1D11
Host
Mouse
Species Reactivity
Human
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purity/Purification
Purified by Protein-A Affinity Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
The mouse monoclonal antibody 1D11 recognizes an extracellular epitope of CD314 / NKG2D, a 42 kDa C-type lectin-like activating receptor expressed by NK cells, gamma/delta T cells, and CD8+ T cells.
Preparation and Storage
Store at 2-8 degree C.
Matching Pairs
Unconjugated Antibody: CD314 Clone #1D11 (MBS1800077)
Unconjugated Azide Free Antibody: CD314 Clone #1D11 (MBS1800076)
Matching Pairs
Unconjugated Antibody: CD314 Clone #1D11 (MBS1800077)
APC Conjugated Antibody: CD314 Clone #1D11 (MBS1800078)
Show more
OMIM
611817
3D Structure
ModBase 3D Structure for P26718
Immunogen
NKL cell line
Applications Tested/Suitable for anti-CD314 antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC) Frozen
Application Notes for anti-CD314 antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-CD314 antibody

Separation of human CD314 positive lymphocytes (red-filled) from CD314 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD314 (1D11) purified antibody (concentration in sample 4 ug/ml) GAM APC.
Mouse Anti-CD314 Monoclonal Antibody – Cat# MBS1800077

Flow Cytometry (FC/FACS) of anti-CD314 antibody

Flow cytometry surface staining pattern of human peripheral blood stained using anti-human CD314 (1D11) purified antibody (concentration in sample 4 ug/ml) GAM APC.
Mouse Anti-CD314 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1800077

Other Notes

Small volumes of anti-CD314 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD314 purchase

MBS1800077 is an antibody targeting CD314. Also known as Anti-Hu CD314 Purified. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD314. It may not necessarily be applicable to this product.

NCBI GI #
315221164
NCBI Accession #
NP_001186734.1
UniProt Primary Accession #
P26718
GenBank Nucleotide #
NP_001186734.1
NCBI Official Full Name
NKG2-D type II integral membrane protein
UniProt Protein Name
NKG2-D type II integral membrane protein
UniProt Synonym Protein Names
Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor
Protein Family
NKG2-D type II integral membrane protein
UniProt Gene Name
KLRK1
UniProt Synonym Gene Names
D12S2489E; NKG2D
UniProt Entry Name
NKG2D_HUMAN

UniProt Comments for CD314

KLRK1: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor activity; carbohydrate binding

Biological Process: regulation of immune response; T cell costimulation; natural killer cell activation; innate immune response; cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; signal transduction
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD314 antibody

 Products by Pathway  Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Organs/Tissues associated with anti-CD314 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with CD314 and Blood
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000