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CD197 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800183

CD197 / CCR7 (chemokine receptor 7) is a seven membrane-spanning protein serving as a receptor for chemokines CCL19 and CCL21. It is expressed on most naive T cells, some hematopoietic stem cells, mature dendritic cells, NK cells and some memory T cells and B… More details

$330 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD197, Monoclonal Antibody
Full Product Name
Anti-Ms CD197 Purified
Product Gene Name
anti-CD197 antibody
Product Synonym Gene Name
Ccr7
Product Synonym Names
chemokine (C-C motif) receptor 7; CCR7; CC-CKR-7; EBI1
Clonality
Monoclonal
Isotype
IgG2a kappa
Clone Number
4B12
Host
Rat
Species Reactivity
Mouse
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purity/Purification
Purified by Protein-G Affinity Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
The rat monoclonal antibody 4B12 recognizes an extracellular epitope of murine CD197 / CCR7 (chemokine receptor 7), a 43 kDa G-protein-coupled receptor for chemokines CCL19 and CCL21.
Preparation and Storage
Store at 2-8 degree C.
Matching Pairs
Unconjugated Antibody: CD197 Clone #4B12 (MBS1800183)
PE Conjugated Antibody: CD197 Clone #4B12 (MBS1800184)
3D Structure
ModBase 3D Structure for P47774
Immunogen
Murine CD197-transfected RBL-2H3 cells
Applications Tested/Suitable for anti-CD197 antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP)
Application Notes for anti-CD197 antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-CD197 antibody

Flow cytometry surface staining pattern of murine splenocytes stained using anti-mouse CD197 (4B12) purified antibody (concentration in sample 4 ug/ml, DAR APC, red) and murine splenocytes unstained by primary antibody (DAR APC, blue).
Rat Anti-CD197 Monoclonal Antibody – Cat# MBS1800183

Other Notes

Small volumes of anti-CD197 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD197 purchase

MBS1800183 is an antibody targeting CD197. Also known as Anti-Ms CD197 Purified. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD197. It may not necessarily be applicable to this product.

NCBI GI #
678246450
NCBI GeneID
12775
NCBI Accession #
NP_001288642.1
UniProt Primary Accession #
P47774
UniProt Related Accession #
P47774
GenBank Nucleotide #
NP_001288642.1
NCBI Official Full Name
C-C chemokine receptor type 7 isoform b
NCBI Official Synonym Full Names
chemokine (C-C motif) receptor 7
NCBI Official Symbol
Ccr7
NCBI Official Synonym Symbols
EBI1; CCR-7; CD197; Ebi1h; Cdw197; Cmkbr7; CC-CKR-7
UniProt Protein Name
C-C chemokine receptor type 7
UniProt Synonym Protein Names
Epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; EBV-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD_antigen: CD197
Protein Family
C-C chemokine receptor
UniProt Gene Name
Ccr7
UniProt Synonym Gene Names
Cmkbr7; Ebi1; Ebi1h; C-C CKR-7; CC-CKR-7; CCR-7; EBI1; EBV-induced G-protein coupled receptor 1
UniProt Entry Name
CCR7_MOUSE
NCBI Protein Information
C-C chemokine receptor type 7

UniProt Comments for CD197

CCR7: Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; GPCR, family 1; Receptor, GPCR

Cellular Component: cell surface; external side of plasma membrane; integral to membrane; intracellular; membrane; plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; G-protein coupled receptor activity; protein binding; signal transducer activity

Biological Process: actin cytoskeleton organization and biogenesis; activation of JNK activity; chemotaxis; establishment of T cell polarity; G-protein coupled receptor protein signaling pathway; homeostasis of number of cells; immune response; inflammatory response; lymph node development; lymphocyte chemotaxis across high endothelial venule; myeloid dendritic cell chemotaxis; negative thymic T cell selection; positive regulation of dendritic cell antigen processing and presentation; positive regulation of filopodium formation; positive regulation of GTPase activity; positive regulation of humoral immune response; positive regulation of hypersensitivity; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-12 production; positive regulation of phagocytosis; positive regulation of receptor-mediated endocytosis; positive regulation of T cell proliferation; positive regulation of T cell receptor signaling pathway; positive regulation of T-helper 1 cell differentiation; positive regulation of tumor necrosis factor production; regulation of interferon-gamma production; regulation of interleukin-1 beta secretion; regulation of tolerance induction to self antigen; response to lipopolysaccharide; signal transduction
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Research Articles on CD197

1. PU.1 plays a pivotal role in DC migration by transactivating the CCR7 gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD197 antibody

 Reference Product  PubMed Publications
 Ccl19 antibody  >482 publications with CD197 and Ccl19
 Cxcl12 antibody  >168 publications with CD197 and Cxcl12
 Cxcl13 antibody  >56 publications with CD197 and Cxcl13
 Ccl17 antibody  >28 publications with CD197 and Ccl17
 TCA4 antibody  >8 publications with CD197 and TCA4

Pathways associated with anti-CD197 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with anti-CD197 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >421 publications with CD197 and Inflammation
 Necrosis Antibodies  >250 publications with CD197 and Necrosis
 Disease Models, Animal Antibodies  >158 publications with CD197 and Disease Models, Animal
 Lung Diseases Antibodies  >140 publications with CD197 and Lung Diseases
 Hypersensitivity Antibodies  >113 publications with CD197 and Hypersensitivity
 Liver Diseases Antibodies  >79 publications with CD197 and Liver Diseases
 Neoplasms, Experimental Antibodies  >64 publications with CD197 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >52 publications with CD197 and Breast Neoplasms
 Fibrosis Antibodies  >47 publications with CD197 and Fibrosis
 Atherosclerosis Antibodies  >46 publications with CD197 and Atherosclerosis

Organs/Tissues associated with anti-CD197 antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >832 publications with CD197 and Lymph Node
 Bone Marrow Antibodies  >270 publications with CD197 and Bone Marrow
 Skin Antibodies  >253 publications with CD197 and Skin
 Spleen Antibodies  >183 publications with CD197 and Spleen
 Liver Antibodies  >128 publications with CD197 and Liver
 Thymus Antibodies  >114 publications with CD197 and Thymus
 Embryonic Tissue Antibodies  >34 publications with CD197 and Embryonic Tissue
 Mammary Gland Antibodies  >2 publications with CD197 and Mammary Gland
 Uncharacterized Tissue Antibodies  >1 publications with CD197 and Uncharacterized Tissue
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