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CD328 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800263

CD328, also known as Siglec-7 or p75/AIRM1, is a 75 kDa type I transmembrane glycoprotein of sialic acid-binding immunoglobulin-like lectin (Siglec) family. CD328 binds to sialylated glycans with alpha2,6 sialyl and alpha2,8 disyalyl residues and mediates… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD328, Monoclonal Antibody
Full Product Name
Anti-Hu CD328 Purified
Product Gene Name
anti-CD328 antibody
Product Synonym Gene Name
SIGLEC7
Product Synonym Names
sialic acid binding Ig like lectin 7; SIGLEC7; p75/AIRM1; D-siglec; SIGLEC-7
Clonality
Monoclonal
Isotype
IgG1
Clone Number
6-434
Host
Mouse
Species Reactivity
Human
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purity/Purification
Purified by Protein-A Affinity Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
The mouse monoclonal antibody 6-434 recognizes an extracellular epitope of CD328 (Siglec-7), a 75 kDa transmembrane glycoprotein expressed mainly on NK cells, dendritic cells and monocytes.
Preparation and Storage
Store at 2-8 degree C.
Matching Pairs
Unconjugated Antibody: CD328 Clone #6-434 (MBS1800263)
PE Conjugated Antibody: CD328 Clone #6-434 (MBS1800264)
OMIM
604410
3D Structure
ModBase 3D Structure for Q9Y286
Immunogen
human dendritic cells
Applications Tested/Suitable for anti-CD328 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD328 antibody
FC/FACS: QC tested

Other Notes

Small volumes of anti-CD328 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD328 purchase

MBS1800263 is an antibody targeting CD328. Also known as Anti-Hu CD328 Purified. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD328. It may not necessarily be applicable to this product.

NCBI GI #
25009269
NCBI GeneID
27036
NCBI Accession #
Q9Y286.1
UniProt Primary Accession #
Q9Y286
UniProt Related Accession #
Q9Y286
NCBI Official Full Name
Sialic acid-binding Ig-like lectin 7
NCBI Official Synonym Full Names
sialic acid binding Ig like lectin 7
NCBI Official Symbol
SIGLEC7
NCBI Official Synonym Symbols
p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1
UniProt Protein Name
Sialic acid-binding Ig-like lectin 7
UniProt Synonym Protein Names
Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; CD_antigen: CD328
Protein Family
Sialic acid-binding Ig-like lectin
UniProt Gene Name
SIGLEC7
UniProt Synonym Gene Names
AIRM1; Siglec-7; AIRM-1
UniProt Entry Name
SIGL7_HUMAN
NCBI Protein Information
sialic acid-binding Ig-like lectin 7

UniProt Comments for CD328

SIGLEC7: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: integral to plasma membrane

Molecular Function: receptor activity; carbohydrate binding

Biological Process: cell adhesion
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Research Articles on CD328

1. Data reported that Siglec-7 was expressed on beta-cells and down-regulated in type 1 and type 2 diabetes and in infiltrating activated immune cells. Furthermore, Siglec-7 seems to play a critical role in the maintenance of an immune-suppressive anti-inflammatory microenvironment, which is lost in diabetes, and may contribute to the manifestation and progression of this metabolic syndrome.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD328 antibody

 Reference Product  PubMed Publications
 PTPN11 antibody  >3 publications with CD328 and PTPN11
 SYK antibody  >1 publications with CD328 and SYK

Diseases associated with anti-CD328 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >4 publications with CD328 and Kidney Diseases
 Nervous System Diseases Antibodies  >2 publications with CD328 and Nervous System Diseases
 Leukemia, Monocytic, Acute Antibodies  >1 publications with CD328 and Leukemia, Monocytic, Acute
 Peripheral Nervous System Diseases Antibodies  >1 publications with CD328 and Peripheral Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with CD328 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-CD328 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >31 publications with CD328 and Blood
 Liver Antibodies  >2 publications with CD328 and Liver
 Spleen Antibodies  >2 publications with CD328 and Spleen
 Eye Antibodies  >1 publications with CD328 and Eye
 Adrenal Gland Antibodies  >1 publications with CD328 and Adrenal Gland
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