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HLA-G Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800293

MBS1800293 is an antibody targeting HLA-G. Also known as Anti-HLA-G Purified Low Endotoxin. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
HLA-G, Antibody
Full Product Name
Anti-HLA-G Purified Low Endotoxin
Product Gene Name
anti-HLA-G antibody
Product Synonym Names
major histocompatibility complex, class I, G
Isotype
IgG2a
Clone Number
87G
Host
Mouse
Species Reactivity
Human
Form/Format
Low endotoxin azide free phosphate buffered saline (PBS) solution, 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.
Purity/Purification
Purified by Protein-A Affinity Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
The antibody 87G recognizes both membrane-bound and soluble forms of HLA-G (HLA-G1 and HLA-G5). HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells. The antibody 87G blocks interaction of HLA-G with inhibitory receptors.
Preparation and Storage
Store at 2-8 degree C.
Matching Pairs
Unconjugated Antibody: HLA-G Clone #87G (MBS1800292)
Unconjugated Low Endotoxin Antibody: HLA-G Clone #87G (MBS1800293)
OMIM
142871
3D Structure
ModBase 3D Structure for P17693
Immunogen
HLA-B27 transgenic mice were imunized with H-2 identical murine cells transfected with and expressing genes encoding HLA-G and human beta2-microglobulin.
Negative Species
Mouse, Rat
Applications Tested/Suitable for anti-HLA-G antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Frozen, ELISA (EIA), Functional
Application Notes for anti-HLA-G antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-HLA-G antibody

Separation of HLA-G transfected LCL cells (red-filled) from non-transfected LCL cells (black-dashed) in flow cytometry analysis (surface staining) stained using anti-HLA-G (87G) purified antibody (concentration in sample 10 ug/ml, GAM APC).
Mouse Anti-HLA-G Antibody – Cat# MBS1800293

Other Notes

Small volumes of anti-HLA-G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HLA-G. It may not necessarily be applicable to this product.

NCBI GI #
122132
NCBI GeneID
3135
NCBI Accession #
P17693.1
UniProt Primary Accession #
P17693
UniProt Related Accession #
P17693
NCBI Official Full Name
HLA class I histocompatibility antigen, alpha chain G
NCBI Official Synonym Full Names
major histocompatibility complex, class I, G
NCBI Official Symbol
HLA-G
NCBI Official Synonym Symbols
MHC-G
UniProt Protein Name
HLA class I histocompatibility antigen, alpha chain G
UniProt Synonym Protein Names
HLA G antigen; MHC class I antigen G
Protein Family
HLA class I histocompatibility antigen
UniProt Gene Name
HLA-G
UniProt Synonym Gene Names
HLA-6.0; HLAG
UniProt Entry Name
HLAG_HUMAN
NCBI Protein Information
HLA class I histocompatibility antigen, alpha chain G

NCBI Summary for HLA-G

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
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Research Articles on HLA-G

1. High HLA-G expression is associated with vulvar squamous cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HLA-G antibody

 Reference Product  PubMed Publications
 CD4 antibody  >100 publications with HLA-G and CD4
 IL10 antibody  >84 publications with HLA-G and IL10
 LILRB2 antibody  >46 publications with HLA-G and LILRB2
 KLRC1 antibody  >11 publications with HLA-G and KLRC1
 LIF antibody  >11 publications with HLA-G and LIF
 ADM2 antibody  >2 publications with HLA-G and ADM2
 SPRY2 antibody  >1 publications with HLA-G and SPRY2

Pathways associated with anti-HLA-G antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram

Diseases associated with anti-HLA-G antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >92 publications with HLA-G and Adenocarcinoma
 Skin Diseases Antibodies  >74 publications with HLA-G and Skin Diseases
 Inflammation Antibodies  >73 publications with HLA-G and Inflammation
 Necrosis Antibodies  >46 publications with HLA-G and Necrosis
 Nervous System Diseases Antibodies  >39 publications with HLA-G and Nervous System Diseases
 Asthma Antibodies  >32 publications with HLA-G and Asthma
 Breast Neoplasms Antibodies  >31 publications with HLA-G and Breast Neoplasms
 Liver Diseases Antibodies  >29 publications with HLA-G and Liver Diseases
 Ovarian Neoplasms Antibodies  >22 publications with HLA-G and Ovarian Neoplasms
 Carcinoma, Squamous Cell Antibodies  >19 publications with HLA-G and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-HLA-G antibody

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >467 publications with HLA-G and Placenta
 Lung Antibodies  >37 publications with HLA-G and Lung
 Brain Antibodies  >28 publications with HLA-G and Brain
 Thymus Antibodies  >23 publications with HLA-G and Thymus
 Stomach Antibodies  >9 publications with HLA-G and Stomach
 Intestine Antibodies  >7 publications with HLA-G and Intestine
 Testis Antibodies  >5 publications with HLA-G and Testis
 Pancreas Antibodies  >3 publications with HLA-G and Pancreas
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