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Clathrin Heavy Chain (CTLC) Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800424

Clathrin is a submembrane protein that polymerizes into coat-like lattices, which results in membrane invagination. The basic oligomers are composed of three clathrin heavy chain (180 kDa) and three light chain (30 kDa) subunits and the process of… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Clathrin Heavy Chain (CTLC), Antibody
Full Product Name
Anti-Clathrin Heavy Chain Purified
Product Gene Name
Product Synonym Names
clathrin heavy chain; CHC; CLHC; MRD56
Isotype
IgM
Clone Number
BF-06
Host
Mouse
Species Reactivity
Rat, Cow, Mouse, Human, Pig
Form/Format
Stabilizing Tris buffered saline (TBS) solution with 15 mM sodium azide
Purity/Purification
Purified by Precipitation and Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
The antibody BF-06 recognizes clathrin heavy chain, an ubiquitously expressed 180 kDa intracellular protein involved in receptor-mediated endocytosis.
Preparation and Storage
Store at 2-8 degree C.
OMIM
D21260 mRNA
3D Structure
ModBase 3D Structure for Q00610
Applications Tested/Suitable for anti-CTLC antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-CTLC antibody
FC/FACS: QC tested

Immunocytochemistry (ICC) of anti-CTLC antibody

Immunocytochemistry staining of clathrin in human primary fibroblasts using anti-clathrin (BF-06; green). Actin cytoskeleton decorated by phalloidin (red) and cell nuclei stained with DAPI (blue).
Mouse Anti-CTLC Antibody – Cat# MBS1800424

Immunocytochemistry (ICC) of anti-CTLC antibody

Immunocytochemistry staining of clathrin in human HeLa cell line using anti-clathrin (BF-06; green). Actin cytoskeleton decorated by phalloidin (red) and cell nuclei stained with DAPI (blue).
Mouse Anti-CTLC Antibody, Immunocytochemistry (ICC) – Cat# MBS1800424

Other Notes

Small volumes of anti-CTLC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTLC purchase

MBS1800424 is an antibody targeting CTLC. Also known as Anti-Clathrin Heavy Chain Purified. Reactive in Rat, Cow, Mouse, Human, Pig. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CTLC. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
clathrin heavy chain 1 isoform 1
NCBI Official Synonym Full Names
clathrin heavy chain
NCBI Official Symbol
CLTC
NCBI Official Synonym Symbols
Hc; CHC; CHC17; MRD56; CLH-17; CLTCL2
UniProt Protein Name
Clathrin heavy chain 1
UniProt Synonym Protein Names
Clathrin heavy chain on chromosome 17; CLH-17
UniProt Gene Name
CLTC
UniProt Synonym Gene Names
CLH17; CLTCL2; KIAA0034; CLH-17
NCBI Protein Information
clathrin heavy chain 1

NCBI Summary for CTLC

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
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UniProt Comments for CTLC

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CTLC antibody

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