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CD261 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800552

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates… More details

$520 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD261, Monoclonal Antibody
Full Product Name
Anti-Hu CD261 PE
Product Gene Name
anti-CD261 antibody
Product Synonym Gene Name
TNFRSF10A
Product Synonym Names
TNF receptor superfamily member 10a; DR4; APO2; TNFRSF10A TRAILR1; TRAIL receptor 1; TRAIL-R1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
DR-4-02
Host
Mouse
Species Reactivity
Human
Form/Format
Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Purity/Purification
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Concentration
0.1 mg/ml (lot specific)
Specificity
The mouse monoclonal antibody DR-4-02 recognizes an extracellular epitope of TRAIL-R1 (DR4), a human death receptor 4 expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
Preparation and Storage
Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.
Matching Pairs
Unconjugated Antibody: CD261 Clone #DR-4-02 (MBS1800548)
PE Conjugated Antibody: CD261 Clone #DR-4-02 (MBS1800552)
OMIM
603611
3D Structure
ModBase 3D Structure for O00220
Immunogen
Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
Conjugation
PE
Applications Tested/Suitable for anti-CD261 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD261 antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-CD261 antibody

Flow cytometry analysis (surface staining) of CD261-transfected HEK-293 cells with anti-CD261/TRAIL-R1 (DR-4-02) PE.
Mouse Anti-CD261 Monoclonal Antibody – Cat# MBS1800552

Other Notes

Small volumes of anti-CD261 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD261 purchase

MBS1800552 is an antibody targeting CD261. Also known as Anti-Hu CD261 PE. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD261. It may not necessarily be applicable to this product.

NCBI GI #
259906438
NCBI GeneID
8797
NCBI Accession #
NP_003835.3
UniProt Primary Accession #
O00220
UniProt Related Accession #
O00220
GenBank Nucleotide #
NP_003835.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 10A
NCBI Official Synonym Full Names
TNF receptor superfamily member 10a
NCBI Official Symbol
TNFRSF10A
NCBI Official Synonym Symbols
DR4; APO2; CD261; TRAILR1; TRAILR-1
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10A
UniProt Synonym Protein Names
Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF10A
UniProt Synonym Gene Names
APO2; DR4; TRAILR1; TRAIL receptor 1; TRAIL-R1
UniProt Entry Name
TR10A_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10A

NCBI Summary for CD261

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD261

TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding; protease binding; death receptor activity; TRAIL binding; receptor activity; transcription factor binding

Biological Process: caspase activation; induction of apoptosis via death domain receptors; apoptosis; activation of NF-kappaB-inducing kinase; signal transduction
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Research Articles on CD261

1. MCL1 inhibition increased DR4 protein levels and its cell surface expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD261 antibody

 Reference Product  PubMed Publications
 TNFRSF10B antibody  >527 publications with CD261 and TNFRSF10B
 TNFSF10 antibody  >522 publications with CD261 and TNFSF10
 CASP8 antibody  >178 publications with CD261 and CASP8
 FADD antibody  >98 publications with CD261 and FADD
 TRADD antibody  >18 publications with CD261 and TRADD
 CD4 antibody  >17 publications with CD261 and CD4
 RIPK1 antibody  >7 publications with CD261 and RIPK1
 DAP3 antibody  >3 publications with CD261 and DAP3
 MADD antibody  >2 publications with CD261 and MADD
 BTK antibody  >1 publications with CD261 and BTK

Pathways associated with anti-CD261 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram

Diseases associated with anti-CD261 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >493 publications with CD261 and Necrosis
 Neoplasms Antibodies  >338 publications with CD261 and Neoplasms
 Adenocarcinoma Antibodies  >60 publications with CD261 and Adenocarcinoma
 Leukemia Antibodies  >54 publications with CD261 and Leukemia
 Drug Toxicity Antibodies  >32 publications with CD261 and Drug Toxicity
 Prostatic Neoplasms Antibodies  >30 publications with CD261 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >29 publications with CD261 and Breast Neoplasms
 Liver Diseases Antibodies  >27 publications with CD261 and Liver Diseases
 Lung Neoplasms Antibodies  >27 publications with CD261 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >27 publications with CD261 and Neoplasms, Experimental

Organs/Tissues associated with anti-CD261 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >74 publications with CD261 and Blood
 Liver Antibodies  >36 publications with CD261 and Liver
 Lung Antibodies  >34 publications with CD261 and Lung
 Prostate Antibodies  >28 publications with CD261 and Prostate
 Brain Antibodies  >17 publications with CD261 and Brain
 Kidney Antibodies  >14 publications with CD261 and Kidney
 Vascular Antibodies  >14 publications with CD261 and Vascular
 Skin Antibodies  >12 publications with CD261 and Skin
 Pancreas Antibodies  >7 publications with CD261 and Pancreas
 Intestine Antibodies  >7 publications with CD261 and Intestine
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