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FOLR2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800604

FOLR2 (folate receptor beta) is a cell surface protein that was originally thought to be specific for placenta, but it can be also expressed in other tissues, including hematopoietic cells. Its expression is increased in malignant tissues. FOLR2 may play a… More details

$385 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FOLR2, Monoclonal Antibody
Full Product Name
Anti-FOLR2 PE
Product Gene Name
Product Synonym Names
folate receptor beta; Folate receptor beta; FBP; FR-P3; FR-BETA; BETA-HFR; FBP/PL-1
Clonality
Monoclonal
Isotype
IgG1
Clone Number
EM-35
Host
Mouse
Species Reactivity
Human
Form/Format
Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Purity/Purification
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Concentration
0.1 mg/ml (lot specific)
Specificity
The mouse monoclonal antibody EM-35 recognizes an extracellular epitope on FOLR2, a 30-40 kDa cell surface protein serving as a receptor for folic acid.
Preparation and Storage
Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.
Matching Pairs
Unconjugated Antibody: FOLR2 Clone #EM-35 (MBS1800603)
PE Conjugated Antibody: FOLR2 Clone #EM-35 (MBS1800604)
OMIM
X69516 Genomic DNA
3D Structure
ModBase 3D Structure for P14207
Immunogen
BW5147alpha,beta- cells
Negative Species
Mouse
Conjugation
PE
Applications Tested/Suitable for anti-FOLR2 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-FOLR2 antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-FOLR2 antibody

Flow cytometry analysis (surface staining) of FOLR2 transfectants (red) with anti-human FOLR2 (EM-35) PE; compared with blank (blue).
Mouse Anti-FOLR2 Monoclonal Antibody – Cat# MBS1800604

Other Notes

Small volumes of anti-FOLR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOLR2 purchase

MBS1800604 is an antibody targeting FOLR2. Also known as Anti-FOLR2 PE. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for FOLR2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
folate receptor beta
NCBI Official Synonym Full Names
folate receptor beta
NCBI Official Symbol
FOLR2
NCBI Official Synonym Symbols
FBP; FOLR1; FR-P3; FRbeta; FR-BETA; BETA-HFR; FBP/PL-1
UniProt Protein Name
Folate receptor beta
UniProt Synonym Protein Names
Folate receptor 2; Folate receptor, fetal/placental; Placental folate-binding protein; FBP
Protein Family
UniProt Gene Name
FOLR2
UniProt Synonym Gene Names
FR-beta; FBP
NCBI Protein Information
folate receptor beta

NCBI Summary for FOLR2

The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for FOLR2

FOLR2: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Belongs to the folate receptor family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: anchored to external side of plasma membrane; cell surface; membrane

Molecular Function: drug binding; folic acid binding; folic acid transporter activity; methotrexate binding

Biological Process: folic acid transport; monocyte chemotaxis; positive regulation of cell proliferation; receptor-mediated endocytosis; regulation of thymidylate synthase biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FOLR2 antibody

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