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NR2F6 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800609

NR2F6 (Nuclear receptor subfamily 2 group F member 6), also known as EAR2 or ERBAL2, is a transcription factor involved in modulation of hormonal responses. NR2F6 represses e.g. transcription of the oxytocin-neurophysin gene, renin gene,… More details

$345 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NR2F6, Monoclonal Antibody
Full Product Name
Anti-NR2F6 Purified
Product Gene Name
anti-NR2F6 antibody
Product Synonym Names
nuclear receptor subfamily 2 group F member 6; EAR2; EAR-2; ERBAL2
Clonality
Monoclonal
Isotype
IgG2a kappa
Clone Number
EM-51
Host
Mouse
Species Reactivity
Human
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purity/Purification
Purified by Protein-A Affinity Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
The mouse monoclonal antibody EM-51 recognizes NR2F6, a transcriptional repressor (intracellular antigen) expressed mainly in the heart, placenta, liver, skeletal muscle, kidney and pancreas, but also e.g. in T cell subpopulations.
Preparation and Storage
Store at 2-8 degree C.
OMIM
132880
3D Structure
ModBase 3D Structure for P10588
Immunogen
Recombinant human NR2F6 protein expressed in E. coli
Applications Tested/Suitable for anti-NR2F6 antibody
Flow Cytometry (FC/FACS), Western Blot (WB)

Flow Cytometry (FC/FACS) of anti-NR2F6 antibody

Separation of human monocytes stained using anti-NR2F6 (EM-51) purified antibody (concentration in sample 3 ug/ml, GAM APC, red-filled) from monocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (intracellular staining).
Mouse Anti-NR2F6 Monoclonal Antibody – Cat# MBS1800609

Flow Cytometry (FC/FACS) of anti-NR2F6 antibody

Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-NR2F6 (EM-51) purified antibody (concentration in sample 3 ug/ml, GAM APC).
Mouse Anti-NR2F6 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1800609

Other Notes

Small volumes of anti-NR2F6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NR2F6 purchase

MBS1800609 is an antibody targeting NR2F6. Also known as Anti-NR2F6 Purified. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for NR2F6. It may not necessarily be applicable to this product.

NCBI GI #
20070199
NCBI GeneID
2063
NCBI Accession #
NP_005225.2
UniProt Primary Accession #
P10588
UniProt Related Accession #
P10588
GenBank Nucleotide #
NP_005225.2
NCBI Official Full Name
nuclear receptor subfamily 2 group F member 6
NCBI Official Synonym Full Names
nuclear receptor subfamily 2 group F member 6
NCBI Official Symbol
NR2F6
NCBI Official Synonym Symbols
EAR2; EAR-2; ERBAL2
UniProt Protein Name
Nuclear receptor subfamily 2 group F member 6
UniProt Synonym Protein Names
V-erbA-related protein 2
Protein Family
Nuclear receptor subfamily
UniProt Gene Name
NR2F6
UniProt Synonym Gene Names
EAR2; ERBAL2; EAR-2
UniProt Entry Name
NR2F6_HUMAN
NCBI Protein Information
nuclear receptor subfamily 2 group F member 6

UniProt Comments for NR2F6

EAR-2: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; neuron development; gene expression; steroid hormone mediated signaling; negative regulation of transcription from RNA polymerase II promoter; signal transduction; detection of temperature stimulus involved in sensory perception of pain; entrainment of circadian clock by photoperiod
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Research Articles on NR2F6

1. circRHOT1 inhibits HCC development and progression via recruiting TIP60 to initiate NR2F6 expression, indicating that circRHOT1 and NR2F6 may be potential biomarkers for HCC prognosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NR2F6 antibody

 Reference Product  PubMed Publications
 NR2F2 antibody  >7 publications with NR2F6 and NR2F2

Pathways associated with anti-NR2F6 antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram

Diseases associated with anti-NR2F6 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with NR2F6 and Neoplasms
 Immune System Diseases Antibodies  >3 publications with NR2F6 and Immune System Diseases
 Carcinoma Antibodies  >2 publications with NR2F6 and Carcinoma
 Brain Diseases Antibodies  >1 publications with NR2F6 and Brain Diseases
 Drug Toxicity Antibodies  >1 publications with NR2F6 and Drug Toxicity
 Cardiovascular Diseases Antibodies  >1 publications with NR2F6 and Cardiovascular Diseases
 Inflammation Antibodies  >1 publications with NR2F6 and Inflammation
 Hyperplasia Antibodies  >1 publications with NR2F6 and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with NR2F6 and Breast Neoplasms

Organs/Tissues associated with anti-NR2F6 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with NR2F6 and Brain
 Liver Antibodies  >3 publications with NR2F6 and Liver
 Nerve Antibodies  >2 publications with NR2F6 and Nerve
 Heart Antibodies  >1 publications with NR2F6 and Heart
 Bone Antibodies  >1 publications with NR2F6 and Bone
 Placenta Antibodies  >1 publications with NR2F6 and Placenta
 Testis Antibodies  >1 publications with NR2F6 and Testis
 Muscle Antibodies  >1 publications with NR2F6 and Muscle
 Kidney Antibodies  >1 publications with NR2F6 and Kidney
 Intestine Antibodies  >1 publications with NR2F6 and Intestine
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