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CD79a Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800744

CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin… More details

$385 / 100 Tests +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD79a, Monoclonal Antibody
Full Product Name
Anti-Hu CD79a PE
Product Gene Name
anti-CD79a antibody
Product Synonym Names
CD79a molecule; BCR alpha; Ig-alpha; MB-1; IGA
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
HM47
Host
Mouse
Species Reactivity
Dog, Chicken, Rabbit, Guinea pig, Horse, Cow, Mouse, Rat, Pig, Non-human primates, Human
Form/Format
Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Purity/Purification
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Specificity
The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
Preparation and Storage
Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.
Matching Pairs
Unconjugated Antibody: CD79a Clone #HM47 (MBS1800742)
PE Conjugated Antibody: CD79a Clone #HM47 (MBS1800744)
OMIM
112205
3D Structure
ModBase 3D Structure for P11912
Immunogen
Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
Conjugation
PE
Applications Tested/Suitable for anti-CD79a antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD79a antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-CD79a antibody

Flow cytometry multicolor surface staining of human lymphocytes using anti-human CD19 (LT19) APC antibody (10 ul reagent / 100 ul of peripheral whole blood) and intracellular staining of human lymphocytes using anti-human CD79a (HM47) PE antibody (10 ul reagent / 100 ul of peripheral whole blood).
Mouse Anti-CD79a Monoclonal Antibody – Cat# MBS1800744

Flow Cytometry (FC/FACS) of anti-CD79a antibody

Separation of human CD79a positive B cells (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood stained using anti-human CD79a (HM47) PE antibody (10 ul reagent / 100 ul of peripheral whole blood).
Mouse Anti-CD79a Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1800744

Flow Cytometry (FC/FACS) of anti-CD79a antibody

Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-human CD79a (HM47) PE antibody (10 ul reagent / 100 ul of peripheral whole blood).
Mouse Anti-CD79a Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1800744

Other Notes

Small volumes of anti-CD79a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD79a purchase

MBS1800744 is an antibody targeting CD79a. Also known as Anti-Hu CD79a PE. Reactive in Dog, Chicken, Rabbit, Guinea pig, Horse, Cow, Mouse, Rat, Pig, Non-human primates, Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD79a. It may not necessarily be applicable to this product.

NCBI GI #
4502685
NCBI GeneID
973
NCBI Accession #
NP_001774.1
UniProt Primary Accession #
P11912
UniProt Related Accession #
P11912
GenBank Nucleotide #
NP_001774.1
NCBI Official Full Name
B-cell antigen receptor complex-associated protein alpha chain isoform 1
NCBI Official Synonym Full Names
CD79a molecule
NCBI Official Symbol
CD79A
NCBI Official Synonym Symbols
IGA; MB-1
UniProt Protein Name
B-cell antigen receptor complex-associated protein alpha chain
UniProt Synonym Protein Names
Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein
Protein Family
B-cell antigen receptor complex-associated protein
UniProt Gene Name
CD79A
UniProt Synonym Gene Names
IGA; MB1
UniProt Entry Name
CD79A_HUMAN
NCBI Protein Information
B-cell antigen receptor complex-associated protein alpha chain

NCBI Summary for CD79a

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD79a

Ig-alpha: an integral membrane protein that associates with surface immunoglobulin B lymphocyte antigen receptor multimeric complex. Surface Ig non-covalently associates with 2 other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: multivesicular body; integral to membrane; plasma membrane; B cell receptor complex; lipid raft; external side of plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: B cell proliferation; B cell receptor signaling pathway; B cell activation; B cell differentiation

Disease: Agammaglobulinemia 3, Autosomal Recessive
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Research Articles on CD79a

1. Aberrant CD79a and/or PAX5 expression can be found in Acute Myelogenous Leukemia cases with RUNX1 mutations even without the translocation t(8; 21).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD79a antibody

 Reference Product  PubMed Publications
 CD79B antibody  >570 publications with CD79a and CD79B
 CD5 antibody  >153 publications with CD79a and CD5
 CD19 antibody  >134 publications with CD79a and CD19
 SYK antibody  >34 publications with CD79a and SYK
 LYN antibody  >22 publications with CD79a and LYN
 FYN antibody  >10 publications with CD79a and FYN
 BLNK antibody  >10 publications with CD79a and BLNK
 BLK antibody  >5 publications with CD79a and BLK
 IGHM antibody  >4 publications with CD79a and IGHM
 PTPN6 antibody  >4 publications with CD79a and PTPN6

Pathways associated with anti-CD79a antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Signaling By The B Cell Receptor (BCR) Pathway antibodies  Signaling By The B Cell Receptor (BCR) Pathway Diagram

Diseases associated with anti-CD79a antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >738 publications with CD79a and Neoplasms
 Lymphoma Antibodies  >641 publications with CD79a and Lymphoma
 Skin Neoplasms Antibodies  >78 publications with CD79a and Skin Neoplasms
 Neoplasms, Experimental Antibodies  >69 publications with CD79a and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >47 publications with CD79a and Cardiovascular Diseases
 Inflammation Antibodies  >41 publications with CD79a and Inflammation
 Hyperplasia Antibodies  >38 publications with CD79a and Hyperplasia
 Liver Diseases Antibodies  >38 publications with CD79a and Liver Diseases
 Necrosis Antibodies  >37 publications with CD79a and Necrosis
 Multiple Myeloma Antibodies  >36 publications with CD79a and Multiple Myeloma

Organs/Tissues associated with anti-CD79a antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >530 publications with CD79a and Blood
 Lymph Node Antibodies  >206 publications with CD79a and Lymph Node
 Lymph Antibodies  >194 publications with CD79a and Lymph
 Spleen Antibodies  >82 publications with CD79a and Spleen
 Liver Antibodies  >77 publications with CD79a and Liver
 Lung Antibodies  >47 publications with CD79a and Lung
 Intestine Antibodies  >40 publications with CD79a and Intestine
 Thymus Antibodies  >30 publications with CD79a and Thymus
 Mouth Antibodies  >21 publications with CD79a and Mouth
 Heart Antibodies  >19 publications with CD79a and Heart
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