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CD18 Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1800812

CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most… More details

$295 / 0.1 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD18, Antibody
Full Product Name
Anti-Bov CD18 Purified
Product Gene Name
anti-CD18 antibody
Product Synonym Gene Name
ITGB2
Product Synonym Names
integrin subunit beta 2; Integrin beta2; Complement receptor C3 subunit beta; ITGB2
Isotype
IgG1
Clone Number
IVA35
Host
Mouse
Species Reactivity
Cow
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purity/Purification
Purified by Protein-A Affinity Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
The antibody IVA35 reacts with an extracellular epitope of CD18 antigen (bovine), a 90-95 kDa type I transmembrane protein (integrin) expressed on all leukocytes.
Preparation and Storage
Store at 2-8 degree C.
3D Structure
ModBase 3D Structure for P32592
Immunogen
Bovine leukocytes.
Applications Tested/Suitable for anti-CD18 antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Immunocytochemistry (ICC) of anti-CD18 antibody

Immunocytochemistry staining of acetone/methanol fixed bovine peripheral blood (lymphocyte-enriched suspension) using anti-bovine CD18 (IVA35); secondary antibody conjugated to FITC (green), DNA stained with DAPI (blue).
Mouse Anti-CD18 Antibody – Cat# MBS1800812

Flow Cytometry (FC/FACS) of anti-CD18 antibody

Separation of bovine lymphocytes stained using anti-bovine CD18 (IVA35) purified antibody (concentration in sample 10 ug/ml, GAM APC, red-filled) from bovine lymphocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).
Mouse Anti-CD18 Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1800812

Flow Cytometry (FC/FACS) of anti-CD18 antibody

Flow cytometry surface staining pattern of bovine peripheral whole blood stained using anti-bovine CD18 (IVA35) purified antibody (concentration in sample 10 ug/ml) GAM APC.
Mouse Anti-CD18 Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1800812

Other Notes

Small volumes of anti-CD18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD18 purchase

MBS1800812 is an antibody targeting CD18. Also known as Anti-Bov CD18 Purified. Reactive in Cow. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD18. It may not necessarily be applicable to this product.

NCBI GI #
417199
NCBI GeneID
281877
NCBI Accession #
P32592.1
UniProt Primary Accession #
P32592
UniProt Related Accession #
P32592
NCBI Official Full Name
Integrin beta-2
NCBI Official Synonym Full Names
integrin subunit beta 2
NCBI Official Symbol
ITGB2
NCBI Official Synonym Symbols
CD18
UniProt Protein Name
Integrin beta-2
UniProt Synonym Protein Names
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18
Protein Family
CD180 antigen
UniProt Gene Name
ITGB2
UniProt Synonym Gene Names
CD18
NCBI Protein Information
integrin beta-2

UniProt Comments for CD18

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
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Research Articles on CD18

1. missense variants in the CD18 signal peptide affect Leukotoxin binding.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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