Mouse Anti-CD147 Antibody – Cat# MBS1801331

CD147 Antibody – Mouse

Name: CD147 Antibody; Mouse; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1801331
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1801331

CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6) also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or TCSF (tumour cell-derived collagenase-stimulatory factor) is an ubiquitously expressed cell surface protein with multiple glycosylated… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD147, Antibody

Full Product Name

Anti-Hu CD147 PE

Product Gene Name

anti-CD147 antibody

Product Synonym Gene Name

BSG

Product Synonym Names

basigin (Ok blood group); Neurothelin; Basigin; LAM6; CSF; 5F7; TCSF; BSG; TCSF; Emprin; OK blood group

Isotype

IgG1

Clone Number

MEM-M6/1

Host

Mouse

Species Reactivity

Human

Form/Format

Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide

Purity/Purification

The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

Specificity

The antibody MEM-M6/1 recognizes an extracellular epitope in the N-terminal Ig domain (D1) of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes. The antibody MEM-M6/1 is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells.

Preparation and Storage

Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.

Matching Pairs

Unconjugated Antibody: CD147 Clone #MEM-M6/1 (MBS1801327)
PE Conjugated Antibody: CD147 Clone #MEM-M6/1 (MBS1801331)

OMIM

109480

3D Structure

ModBase 3D Structure for P35613

Immunogen

Protein A-CR purified soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the hinge region, CH2-and CH3 domain of human IgG1 (CD147Rg is secreted by transfectants as a dimer).

Conjugation

Applications Tested/Suitable for anti-CD147 antibody

Flow Cytometry (FC/FACS)

Application Notes for anti-CD147 antibody

FC/FACS: QC tested

Other Notes

Small volumes of anti-CD147 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD147 purchase

MBS1801331 is an antibody targeting CD147. Also known as Anti-Hu CD147 PE. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD147. It may not necessarily be applicable to this product.

NCBI GI #

38372919

NCBI GeneID

682

NCBI Accession #

NP_001719.2

UniProt Primary Accession #

P35613

UniProt Related Accession #

P35613

GenBank Nucleotide #

NP_001719.2

NCBI Official Full Name

basigin isoform 1

NCBI Official Synonym Full Names

basigin (Ok blood group)

NCBI Official Symbol

BSG

NCBI Official Synonym Symbols

OK; 5F7; TCSF; CD147; EMPRIN; EMMPRIN; SLC7A11

UniProt Protein Name

Basigin

UniProt Synonym Protein Names

5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor

UniProt Gene Name

BSG

UniProt Synonym Gene Names

EMMPRIN; TCSF

UniProt Entry Name

BASI_HUMAN

NCBI Protein Information

basigin

NCBI Summary for CD147

The protein encoded by this gene, basigin, is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. Basigin is also a member of the immunoglobulin superfamily, ubiquitously expressed in various tissues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]

UniProt Comments for CD147

BSG: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: Golgi membrane; focal adhesion; membrane; mitochondrion; integral to plasma membrane; melanosome; plasma membrane; sarcolemma; acrosomal membrane; lipid raft

Molecular Function: mannose binding; protein binding

Biological Process: response to peptide hormone stimulus; extracellular matrix organization and biogenesis; response to cAMP; decidualization; odontogenesis of dentine-containing teeth; response to mercury ion; cellular metabolic process; extracellular matrix disassembly; cell surface receptor linked signal transduction; blood coagulation; pyruvate metabolic process; leukocyte migration; embryo implantation

Disease: Blood Group--ok

Research Articles on CD147

1. CD147 antigen promoted glycolytic metabolism in hepatocellular carcinoma (HCC) and was related to immunosuppression in HCC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD147 antibody

Reference Product	PubMed Publications
SLC16A3 antibody	>4 publications with CD147 and SLC16A3
MMP1 antibody	>4 publications with CD147 and MMP1
CAV1 antibody	>3 publications with CD147 and CAV1
SLC16A1 antibody	>1 publications with CD147 and SLC16A1
PPIL2 antibody	>1 publications with CD147 and PPIL2

Pathways associated with anti-CD147 antibody

Products by Pathway	Pathway Diagram
Basigin Interactions Pathway antibodies	Basigin Interactions Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Integrin Cell Surface Interactions Pathway antibodies	Integrin Cell Surface Interactions Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Pyruvate Metabolism Pathway antibodies	Pyruvate Metabolism Pathway Diagram
Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway antibodies	Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Syndecan-1-mediated Signaling Events Pathway antibodies	Syndecan-1-mediated Signaling Events Pathway Diagram

Diseases associated with anti-CD147 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>270 publications with CD147 and Neoplasms
Carcinoma Antibodies	>130 publications with CD147 and Carcinoma
Neoplasm Metastasis Antibodies	>71 publications with CD147 and Neoplasm Metastasis
Neoplasm Invasiveness Antibodies	>54 publications with CD147 and Neoplasm Invasiveness
Inflammation Antibodies	>43 publications with CD147 and Inflammation
Immune System Diseases Antibodies	>41 publications with CD147 and Immune System Diseases
Liver Diseases Antibodies	>36 publications with CD147 and Liver Diseases
Breast Neoplasms Antibodies	>32 publications with CD147 and Breast Neoplasms
Liver Neoplasms Antibodies	>30 publications with CD147 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>30 publications with CD147 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-CD147 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>330 publications with CD147 and Blood
Brain Antibodies	>167 publications with CD147 and Brain
Vascular Antibodies	>88 publications with CD147 and Vascular
Nerve Antibodies	>49 publications with CD147 and Nerve
Liver Antibodies	>47 publications with CD147 and Liver
Muscle Antibodies	>46 publications with CD147 and Muscle
Lung Antibodies	>42 publications with CD147 and Lung
Eye Antibodies	>39 publications with CD147 and Eye
Heart Antibodies	>32 publications with CD147 and Heart
Embryonic Tissue Antibodies	>31 publications with CD147 and Embryonic Tissue