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SCIMP Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1801421

SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with… More details

$345 / 0.1 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SCIMP, Monoclonal Antibody
Full Product Name
Anti-SCIMP Purified
Product Gene Name
Product Synonym Names
SLP adaptor and CSK interacting membrane protein; NVL
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
NVL-07
Host
Mouse
Species Reactivity
Human
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purity/Purification
Purified by Protein-A Affinity Chromatography
Concentration
1 mg/ml (lot specific)
Specificity
The mouse monoclonal antibody NVL-07 recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.
Preparation and Storage
Store at 2-8 degree C.
OMIM
614406
3D Structure
ModBase 3D Structure for Q6UWF3
Immunogen
Recombinant intracellular part of human SCIMP
Applications Tested/Suitable for anti-SCIMP antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB), Immunocytochemistry (ICC)

Western Blot (WB) of anti-SCIMP antibody

Western blotting analysis of human SCIMP using mouse monoclonal antibody NVL-07 on lysates of human SCIMP transfectants under reducing and non-reducing conditions. Nitrocellulose membrane was probed with 2 ug/ml of mouse monoclonal antibody followed by IRDye800-conjugated anti-mouse secondary antibody. SCIMP was detected around 17-22 kDa.
Mouse Anti-SCIMP Monoclonal Antibody – Cat# MBS1801421

Flow Cytometry (FC/FACS) of anti-SCIMP antibody

Flow cytometry analysis (intracellular staining) of SCIMP in a population of HEK-293T-SCIMP transfectants using monoclonal antibody (clone NVL-07, purified).The staining pattern reflects heterogeneity in the cell population regarding transfection efficiency.
Mouse Anti-SCIMP Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1801421

Other Notes

Small volumes of anti-SCIMP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SCIMP purchase

MBS1801421 is an antibody targeting SCIMP. Also known as Anti-SCIMP Purified. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SCIMP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
SLP adapter and CSK-interacting membrane protein isoform 2
NCBI Official Synonym Full Names
SLP adaptor and CSK interacting membrane protein
NCBI Official Symbol
SCIMP
NCBI Official Synonym Symbols
UNQ5783; C17orf87
UniProt Protein Name
SLP adapter and CSK-interacting membrane protein
UniProt Synonym Protein Names
SLP65/SLP76, Csk-interacting membrane protein
UniProt Gene Name
SCIMP
UniProt Synonym Gene Names
C17orf87
UniProt Entry Name
SCIMP_HUMAN
NCBI Protein Information
SLP adapter and CSK-interacting membrane protein

NCBI Summary for SCIMP

This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
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UniProt Comments for SCIMP

UNQ5783: Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: membrane; integral to membrane; immunological synapse

Molecular Function: protein binding
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SCIMP antibody

 Reference Product  PubMed Publications
 GAPT antibody  >1 publications with SCIMP and GAPT

Organs/Tissues associated with anti-SCIMP antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with SCIMP and Blood
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