Rabbit Anti-LIME1 Polyclonal Antibody – Cat# MBS1801453

LIME1 Antibody – Rabbit Polyclonal

Name: LIME1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1801453
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1801453

LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and… More details

$370 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LIME1, Polyclonal Antibody

Full Product Name

Anti-LIME1 Purified

Product Gene Name

anti-LIME1 antibody

Product Synonym Names

Lck interacting transmembrane adaptor 1; LITA1

Clonality

Polyclonal

Clone Number

PAb (410)

Host

Rabbit

Species Reactivity

Human

Form/Format

Phosphate buffered saline (PBS) solution with 15 mM sodium azide

Purity/Purification

Purified from Rabbit Serum by Precipitation Methods

Concentration

1 mg/ml (lot specific)

Specificity

The polyclonal antibody reacts with the cytoplasmic domain of LIME, a 30 kDa Lck-interacting transmembrane adaptor expressed by T cells.

Preparation and Storage

Store at 2-8 degree C.

OMIM

609809

3D Structure

ModBase 3D Structure for Q9H400

Immunogen

Bacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME.

Negative Species

Mouse

Applications Tested/Suitable for anti-LIME1 antibody

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Other Notes

Small volumes of anti-LIME1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LIME1 purchase

MBS1801453 is an antibody targeting LIME1. Also known as Anti-LIME1 Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LIME1. It may not necessarily be applicable to this product.

NCBI GI #

157388906

NCBI GeneID

54923

NCBI Accession #

NP_060276.2

UniProt Primary Accession #

Q9H400

UniProt Related Accession #

Q9H400

GenBank Nucleotide #

NP_060276.2

NCBI Official Full Name

lck-interacting transmembrane adapter 1 isoform 1

NCBI Official Synonym Full Names

Lck interacting transmembrane adaptor 1

NCBI Official Symbol

LIME1

NCBI Official Synonym Symbols

LIME; dJ583P15.4

UniProt Protein Name

Lck-interacting transmembrane adapter 1

UniProt Synonym Protein Names

Lck-interacting molecule

Protein Family

Lck-interacting transmembrane adapter

UniProt Gene Name

LIME1

UniProt Synonym Gene Names

LIME; Lck-interacting membrane protein

UniProt Entry Name

LIME1_HUMAN

NCBI Protein Information

lck-interacting transmembrane adapter 1

NCBI Summary for LIME1

This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

UniProt Comments for LIME1

LIME1: Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular space; plasma membrane; integral to membrane

Biological Process: B cell receptor signaling pathway; T cell receptor signaling pathway

Research Articles on LIME1

1. Results identified one differentially methylated region associated with cerebral palsy within the transcription start site of the LIME1 gene, which plays a key role in inflammatory pathways.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-LIME1 antibody

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