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SLP76 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1801455

SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog… More details

$370 / 0.1 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SLP76, Polyclonal Antibody
Full Product Name
Anti-SLP76 Purified
Product Gene Name
anti-SLP76 antibody
Product Synonym Gene Name
LCP2
Product Synonym Names
lymphocyte cytosolic protein 2; SLP-76; LCP2
Clonality
Polyclonal
Clone Number
PAb (412)
Host
Rabbit
Species Reactivity
Human
Form/Format
Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Purity/Purification
Purified from Rabbit Serum by Precipitation Methods
Concentration
1 mg/ml (lot specific)
Specificity
The polyclonal antibody reacts with SLP76, a 76kDa cytosolic adaptor protein that is involved in signaling of various hematopoietic cells, such as T cells, mast cells or neutrophils; in B cells, however, it is replaced by SLP65.
Preparation and Storage
Store at 2-8 degree C.
OMIM
601603
3D Structure
ModBase 3D Structure for Q13094
Immunogen
Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
Applications Tested/Suitable for anti-SLP76 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Immunohistochemistry (IHC)-Paraffin of anti-SLP76 antibody

Immunohistochemistry staining of human thymus (paraffin sections) with anti-SLP76 polyclonal.
Commercially tested by LifeSpan BioSciences.
Rabbit Anti-SLP76 Polyclonal Antibody – Cat# MBS1801455

Other Notes

Small volumes of anti-SLP76 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLP76 purchase

MBS1801455 is an antibody targeting SLP76. Also known as Anti-SLP76 Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLP76. It may not necessarily be applicable to this product.

NCBI GI #
5031855
NCBI GeneID
3937
NCBI Accession #
NP_005556.1
UniProt Primary Accession #
Q13094
UniProt Related Accession #
Q13094
GenBank Nucleotide #
NP_005556.1
NCBI Official Full Name
lymphocyte cytosolic protein 2
NCBI Official Synonym Full Names
lymphocyte cytosolic protein 2
NCBI Official Symbol
LCP2
NCBI Official Synonym Symbols
SLP76; SLP-76
UniProt Protein Name
Lymphocyte cytosolic protein 2
UniProt Synonym Protein Names
SH2 domain-containing leukocyte protein of 76 kDa; SLP-76 tyrosine phosphoprotein
Protein Family
Lymphocyte cytosolic protein
UniProt Gene Name
LCP2
UniProt Synonym Gene Names
SLP76
UniProt Entry Name
LCP2_HUMAN
NCBI Protein Information
lymphocyte cytosolic protein 2

NCBI Summary for SLP76

This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]
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Research Articles on SLP76

1. Findings reveal that ADAP acts upstream of SLP-76 to convert labile, Ca(2+)-competent microclusters into stable adhesive junctions with enhanced signaling potential.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLP76 antibody

 Reference Product  PubMed Publications
 SYK antibody  >1 publications with SLP76 and SYK
 ITK antibody  >1 publications with SLP76 and ITK
 VAV1 antibody  >1 publications with SLP76 and VAV1
 FYB antibody  >1 publications with SLP76 and FYB

Pathways associated with anti-SLP76 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 FCERI Mediated Ca+2 Mobilization Pathway antibodies  FCERI Mediated Ca+2 Mobilization Pathway Diagram
 FCERI Mediated MAPK Activation Pathway antibodies  FCERI Mediated MAPK Activation Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram

Diseases associated with anti-SLP76 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with SLP76 and Neoplasms
 Mammary Neoplasms, Experimental Antibodies  >1 publications with SLP76 and Mammary Neoplasms, Experimental
 Drug Toxicity Antibodies  >1 publications with SLP76 and Drug Toxicity
 Mammary Neoplasms, Animal Antibodies  >1 publications with SLP76 and Mammary Neoplasms, Animal
 Carcinoma, Squamous Cell Antibodies  >1 publications with SLP76 and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >1 publications with SLP76 and Lung Diseases
 Neoplasms, Experimental Antibodies  >1 publications with SLP76 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >1 publications with SLP76 and Kidney Diseases
 Necrosis Antibodies  >1 publications with SLP76 and Necrosis

Organs/Tissues associated with anti-SLP76 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with SLP76 and Blood
 Nerve Antibodies  >1 publications with SLP76 and Nerve
 Kidney Antibodies  >1 publications with SLP76 and Kidney
 Vascular Antibodies  >1 publications with SLP76 and Vascular
 Lung Antibodies  >1 publications with SLP76 and Lung
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