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CFP-10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1801463

MBS1801463 is an antibody targeting CFP-10. Also known as Anti-CFP-10 (M. tuberculosis) Purified. Reactive in Mycobacterium tuberculosis. Host: Rabbit. More details

$370 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CFP-10, Polyclonal Antibody
Full Product Name
Anti-CFP-10 (M. tuberculosis) Purified
Product Gene Name
anti-CFP-10 antibody
Product Synonym Gene Name
esxB
Product Synonym Names
ESAT-6-like protein EsxB; CFP-10; CFP10; Rv3874; LHP; Mycobacterium tuberculosis esxB antigen
Clonality
Polyclonal
Clone Number
PAb (490)
Host
Rabbit
Species Reactivity
Mycobacterium tuberculosis
Form/Format
Phosphate buffered saline (PBS), pH 7.4, 15mM sodium azide
Purity/Purification
Purified by ligand affinity chromatography
Concentration
1 mg/ml (lot specific)
Specificity
The rabbit polyclonal antibody to CFP10 recognizes the CFP10 (Rv3874) protein of Mycobacterium tuberculosis and Mycobacterium bovis.
Preparation and Storage
Store at 2-8°C. Do not freeze.
3D Structure
ModBase 3D Structure for P9WNK5
Immunogen
CFP-10 (Rv3874) of Mycobacterium tuberculosis
Antigen
CFP-10 (M. tuberculosis)
Applications Tested/Suitable for anti-CFP-10 antibody
Western Blot (WB)
Application Notes for anti-CFP-10 antibody
WB: 0.5-1ug/ml (reducing conditions)

Other Notes

Small volumes of anti-CFP-10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CFP-10. It may not necessarily be applicable to this product.

NCBI GI #
15611010
NCBI GeneID
886194
NCBI Accession #
NP_218391.1
UniProt Primary Accession #
P9WNK5
UniProt Related Accession #
P9WNK5
GenBank Nucleotide #
NP_218391.1
NCBI Official Full Name
ESAT-6-like protein EsxB
NCBI Official Symbol
esxB
NCBI Official Synonym Symbols
cfp10; lhp
UniProt Protein Name
ESAT-6-like protein EsxB
UniProt Synonym Protein Names
10 kDa culture filtrate antigen CFP-10; Secreted antigenic protein MTSA-10
UniProt Gene Name
esxB
UniProt Synonym Gene Names
cfp10; lhp; mtsA10
UniProt Entry Name
ESXB_MYCTU
NCBI Protein Information
ESAT-6-like protein EsxB

UniProt Comments for CFP-10

A secreted protein. Acts as a strong host (human) T-cell antigen (PubMed:11940590). Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm (PubMed:17604718). Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA; native protein binds poorly to artificial liposomes in the absence or presence of EsxA (PubMed:17557817, PubMed:26260636). EsxA and EsxA-EsxB are cytotoxic to pneumocytes (PubMed:19906174). EsxB (and EsxA-EsxB but not EsxA alone) activates human neutrophils; EsxB transiently induces host (human) intracellular Ca2+ mobility in a dose-dependent manner, monocytes and lymphocytes do not respond (PubMed:25332123). Neutrophils respond to EsxB by chemotaxis and primed neutrophils treated with EsxB produce reactive oxygen species (ROS); Ca2+ release and the ROS burst via are induced by an unidentified G-protein coupled receptor (PubMed:25332123). May help regulate assembly and function of the type VII secretion system (T7SS) (PubMed:25865481).
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Research Articles on CFP-10

1. Report cytotoxic T-cell immunogenicity of Rv3615c antigen and diagnostic performances of an ESAT-6/CFP-10/Rv3615c antigen cocktail for diagnosis Mycobacterium tuberculosis infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CFP-10 antibody

 Reference Product  PubMed Publications
 esxA antibody  >25 publications with CFP-10 and esxA
 PE35 antibody  >1 publications with CFP-10 and PE35
 ppe68 antibody  >1 publications with CFP-10 and ppe68
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