MRCK Alpha (MRCKA) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]

MRCKA: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; DMPK family; GEK subfamily

Chromosomal Location of Human Ortholog: 1q42.11

Cellular Component: cytoplasm; leading edge; actomyosin; intercellular junction

Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding

Biological Process: cell migration; regulation of catalytic activity; actomyosin structure organization and biogenesis; actin cytoskeleton reorganization; microtubule cytoskeleton organization and biogenesis; nuclear migration; protein amino acid phosphorylation