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CD263 Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1801599

TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein… More details

$435 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD263, Antibody
Full Product Name
Anti-Hu CD263 FITC
Product Gene Name
Product Synonym Gene Name
TNFRSF10C
Product Synonym Names
TNF receptor superfamily member 10c; TNFRSF10C; Decoy receptor 1; DcR1; TRAIL receptor 3; TRAIL-R3; TRAILR3; TRID; LIT
Isotype
IgG1
Clone Number
TRAIL-R3-02
Host
Mouse
Species Reactivity
Human
Form/Format
Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Purity/Purification
The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Concentration
0.1 mg/ml (lot specific)
Specificity
The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
Preparation and Storage
Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.
OMIM
603613
3D Structure
ModBase 3D Structure for O14798
Immunogen
TRAIL-R3 (aa 1-280) - hIgGhc fusion protein
Conjugation
FITC
Applications Tested/Suitable for anti-CD263 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD263 antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-CD263 antibody

Separation of CD263 transfected HEK-293 cells stained using anti-human CD263 (TRAIL-R3-02) FITC antibody (concentration in sample 15 ug/ml, red-filled) from CD263 transfected HEK-293 cells stained using mouse IgG1 isotype control (MOPC-21) FITC antibody (concentration in sample 15 ug/ml, same as CD263 FITC concentration, black-dashed) in flow cytometry analysis (surface staining) of CD263 transfected HEK-293 cell suspension.
Mouse Anti-CD263 Antibody – Cat# MBS1801599

Other Notes

Small volumes of anti-CD263 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD263 purchase

MBS1801599 is an antibody targeting CD263. Also known as Anti-Hu CD263 FITC. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD263. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
Tumor necrosis factor receptor superfamily member 10C
NCBI Official Synonym Full Names
TNF receptor superfamily member 10c
NCBI Official Symbol
TNFRSF10C
NCBI Official Synonym Symbols
LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10C
UniProt Synonym Protein Names
Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD_antigen: CD263
UniProt Gene Name
TNFRSF10C
UniProt Synonym Gene Names
DCR1; LIT; TRAILR3; TRID; DcR1; TRAIL receptor 3; TRAIL-R3
UniProt Entry Name
TR10C_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10C

NCBI Summary for CD263

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD263

TRAIL-R3: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 8p22-p21

Cellular Component: integral to plasma membrane

Molecular Function: transmembrane receptor activity; TRAIL binding

Biological Process: apoptosis; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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