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TRIM Antibody – Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1801607

TRIM (T cell receptor-interacting molecule), also known as TRAT1 (T cell receptor associated transmembrane adaptor 1) is a 30 kDa protein expressed by T cells as a cystein-linked homodimer. It associates with TCR-CD3-zeta-chain complex and becomes… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TRIM, Antibody
Full Product Name
Anti-TRIM PE
Product Gene Name
anti-TRIM antibody
Product Synonym Gene Name
TRAT1
Product Synonym Names
T cell receptor associated transmembrane adaptor 1; TRAT; TCRIM
Isotype
IgG2a
Clone Number
TRIM-04
Host
Mouse
Species Reactivity
Human
Form/Format
Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Purity/Purification
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Concentration
0.1 mg/ml (lot specific)
Specificity
The antibody TRIM-04 recognizes an intracellular epitope of T cell receptor-interacting molecule (TRIM), a 30 kDa adaptor protein expressed by T cells.
Preparation and Storage
Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.
Matching Pairs
Unconjugated Antibody: TRIM Clone #TRIM-04 (MBS1801606)
PE Conjugated Antibody: TRIM Clone #TRIM-04 (MBS1801607)
OMIM
604962
3D Structure
ModBase 3D Structure for Q6PIZ9
Immunogen
Recombinant intracellular domain (aa 29-186) of human TRIM.
Negative Species
Mouse
Conjugation
PE
Applications Tested/Suitable for anti-TRIM antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-TRIM antibody
FC/FACS: QC tested

Flow Cytometry (FC/FACS) of anti-TRIM antibody

Flow cytometry multicolor surface staining of human lymphocytes using anti-human CD3 (UCHT1) APC antibody (10 ul reagent / 100 ul of peripheral whole blood) and intracellular staining of human lymphocytes using anti-TRIM (TRIM-04) PE antibody (concentration in sample 1 ug/ml).
Mouse Anti-TRIM Antibody – Cat# MBS1801607

Flow Cytometry (FC/FACS) of anti-TRIM antibody

Comparison of anti-TRIM (TRIM-04) PE antibody nonspecific intracellular staining (red) and mouse IgG2a Isotype control (MOPC-173) PE antibody nonspecific intracellular staining (concentration in sample 5 ug/ml, same as anti-TRIM PE concentration, blue) co-stained by anti-mouse CD3 (145-2C11) APC antibody (concentration in sample 1,2 ug/ml) in flow cytometry analysis of murine splenocyte suspension.

Clone TRIM-04 is not specific for murine TRIM.
Mouse Anti-TRIM Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1801607

Flow Cytometry (FC/FACS) of anti-TRIM antibody

Separation of TRIM positive CD3 positive human lymphocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood stained using anti-TRIM (TRIM-04) PE antibody (concentration in sample 1 ug/ml).
Mouse Anti-TRIM Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1801607

Flow Cytometry (FC/FACS) of anti-TRIM antibody

Comparison of anti-TRIM (TRIM-04) PE antibody nonspecific staining (blue-filled) and mouse IgG2a Isotype control (MOPC-173) PE antibody nonspecific staining (concentration in sample 5 ug/ml, same as anti-TRIM PE concentration, black-dashed) in flow cytometry analysis (intracellular staining) of murine splenocyte suspension.

Clone TRIM-04 is not specific for murine TRIM.
Mouse Anti-TRIM Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1801607

Flow Cytometry (FC/FACS) of anti-TRIM antibody

Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-TRIM (TRIM-04) PE antibody (concentration in sample 1 ug/ml).
Mouse Anti-TRIM Antibody, Flow Cytometry (FC/FACS) – Cat# MBS1801607

Other Notes

Small volumes of anti-TRIM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIM purchase

MBS1801607 is an antibody targeting TRIM. Also known as Anti-TRIM PE. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIM. It may not necessarily be applicable to this product.

NCBI GI #
54607137
NCBI GeneID
50852
NCBI Accession #
NP_057472.2
UniProt Primary Accession #
Q6PIZ9
UniProt Related Accession #
Q6PIZ9
GenBank Nucleotide #
NP_057472.2
NCBI Official Full Name
T-cell receptor-associated transmembrane adapter 1 isoform 1
NCBI Official Synonym Full Names
T cell receptor associated transmembrane adaptor 1
NCBI Official Symbol
TRAT1
NCBI Official Synonym Symbols
TRIM; TCRIM; HSPC062; pp29/30
UniProt Protein Name
T-cell receptor-associated transmembrane adapter 1
UniProt Synonym Protein Names
T-cell receptor-interacting molecule; TRIM; pp29/30
Protein Family
Trimeric intracellular cation channel
UniProt Gene Name
TRAT1
UniProt Synonym Gene Names
TCRIM; TRIM
UniProt Entry Name
TRAT1_HUMAN
NCBI Protein Information
T-cell receptor-associated transmembrane adapter 1

UniProt Comments for TRIM

TRAT1: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane

Molecular Function: transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of T cell receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; cellular defense response; innate immune response; positive regulation of calcium-mediated signaling; negative regulation of receptor recycling; negative regulation of transport; signal transduction; T cell receptor signaling pathway
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Research Articles on TRIM

1. TRIM proteins trim the balance of homoeostasis by modulating various biological pathways through protein-protein interactions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRIM antibody

 Reference Product  PubMed Publications
 CD4 antibody  >2 publications with TRIM and CD4
 ZAP70 antibody  >2 publications with TRIM and ZAP70
 CD3D antibody  >2 publications with TRIM and CD3D
 CD8A antibody  >1 publications with TRIM and CD8A
 CD3G antibody  >1 publications with TRIM and CD3G

Pathways associated with anti-TRIM antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram

Organs/Tissues associated with anti-TRIM antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with TRIM and Blood
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