Rho/Rac Guanine Nucleotide Exchange Factor 2 (Ab-885) (ARHGEF2) Antibody – Rabbit

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

ARHGEF2: a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. Mediates cross-talk between microtubules and the actin cytoskeleton. Contains a phorbol esters/diacylglycerol binding and PH domain.

Protein type: Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: Golgi apparatus; microtubule; cytoskeleton; protein complex; focal adhesion; tight junction; cell soma; cytoplasmic membrane-bound vesicle; cytoplasm; spindle; dendritic shaft; cytosol; vesicle

Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; Rho GTPase binding; zinc ion binding; Rac guanyl-nucleotide exchange factor activity; microtubule binding; Rac GTPase binding; transcription factor binding

Biological Process: mitosis; nerve growth factor receptor signaling pathway; negative regulation of microtubule depolymerization; positive regulation of apoptosis; cell morphogenesis; actin filament organization; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; activation of NF-kappaB transcription factor; negative regulation of neurogenesis; regulation of cell proliferation; intracellular protein transport; regulation of small GTPase mediated signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; establishment of mitotic spindle orientation; cell division; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; innate immune response; positive regulation of transcription from RNA polymerase II promoter