Human THSD7A Recombinant Protein – Cat# MBS184013

Thrombospondin Type-1 Domain-Containing 7a (THSD7A) Human Recombinant Protein

Name: THSD7A Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS184013
Price: 570 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS184013

THSD7A was first identified as an endothelial protein that is expressed in the vascularsystem of the placenta. It is expressed by cells of endothelial and neuronal lineage. The soluble form of THSD7A promotes endothelial cell migration and filopodia formation… More details

$570 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Thrombospondin Type-1 Domain-Containing 7A (THSD7A), Recombinant Protein

Full Product Name

Recombinant Human Thrombospondin Type-1 Domain-Containing Protein 7A, THSD7A

Product Gene Name

THSD7A recombinant protein

Product Synonym Names

Thrombospondin Type-1 Domain-Containing Protein 7A

Sequence

AAQGEAEAPT LYLWKTGPWG RCMGDECGPG GIQTRAVWCA HVEGWTTLHT NCKQAERPNN QQNCFKVCDW HKELYDWRLG PWNQCQPVIS KSLEKPLECI KGEEGIQVRE IACIQKDKDI PAEDIICEYF EPKPLLEQAC LIPCQQDCIV SEFSAWSECS KTCGSGLQHR TRHVVAPPQF GGSGCPNLTE FQVCQSSPCE AEELRYSLHV GPWSTCSMPH SRQVRQARRR GKNKEREKDR SKGVKDPEAR ELIKKKRNRN RQNRQENKYW DIQIGYQTRE VMCINKTGKA ADLSFCQQEK LPMTFQSCVI TKECQVSEWS EWSPCSKTCH DMVSPAGTRV RTRTIRQFPI GSEKECPEFE EKEPCLSQGD GVVPCATYGW RTTEWTECRV DPLLSQQDKR RGNQTALCGG GIQTREVYCV QANENLLSQL STHKNKEASK PMDLKLCTGP IPNTTQLCHI PCPTECEVSP WSAWGPCTYE NCNDQQGKKG FKLRKRRITN EPTGGSGVTG NCPHLLEAIP CEEPACYDWK AVRLGNCEPD NGKECGPGTQ VQEVVCINSD GEEVDRQLCR DAIFPIPVAC DAPCPKDCVL STWSTWSSCS HTCSGKTTEG KQIRARSILA YAGEEGGIRC PNSSALQEVR SCNEHPCTVY HWQTGPWGQC IEDTSVSSFN TTTTWNGEAS CSVGMQTRKV ICVRVNVGQV GPKKCPESLR PETVRPCLLP CKKDCIVTPY SDWTSCPSSC KEGDSSIRKQ SRHRVIIQLP ANGGRDCTDP LYEEKACEAP QACQSYRWKT HKWRRCQLVP WSVQQDSPGA QEGCGPGRQA RAITCRKQDG GQAGIHECLQ YAGPVPALTQ ACQIPCQDDC QLTSWSKFSS CNGDCGAVRT RKRTLVGKSK KKEKCKNSHL YPLIETQYCP CDKYNAQPVG NWSDCILPEG KVEVLLGMKV QGDIKECGQG YRYQAMACYD QNGRLVETSR CNSHGYIEEA CIIPCPSDCK LSEWSNWSRC SKSCGSGVKV RSKWLREKPY NGGRPCPKLD HVNQAQVYEV VPCHSDCNQY LWVTEPWSIC KVTFVNMREN CGEGVQTRKV RCMQNTADGP SEHVEDYLCD PEEMPLGSRV CKLPCPEDCV ISEWGSGHHH HHHHHHH

Species Reactivity

Human

Form/Format

PBS 10% Glycerol

Purity/Purification

>95% as estimated by SDS-PAGE stained with Instant Blue Stain (Expedeon).

Preparation and Storage

Store at -20 degree or -80 degree C preferably in small aliquots to avoid repeated freeze-thaw cycles
Ships on Dry Ice

Molecular Weight

Predicted Molecular Weight: 127.6 kDa
Estimate MW SDS-PAGE: ≈ 120 kDa

Sequence Positions

48-1171aa

3D Structure

ModBase 3D Structure for Q9UPZ6

Source

HEK293

Tag

10xHis at the C-terminus

Endotoxin

Less than 0.1ng/ug (1 IEU/ug), as measured by LAL method.

Amount Sent

1 x 25 ul of 4.9mg/mL by A280 absorbance = 122ug (lot specific)

Dry Ice Shipment

Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product References and Citations for THSD7A recombinant protein

Fresquet M., Rhoden S.J., Jowitt TA., McKenzie EA., Roberts I., Lennon R. and PE. Brenchley. Autoantigens PLA2R1 and THSD7A in Membranous Nephropathy Share a Common Epitope Motif in the N-terminal Domain. Journal of Autoimmunity. 106, pp 1-12. 2020.

Other Notes

Small volumes of THSD7A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for THSD7A purchase

MBS184013 is a recombinant protein targeting THSD7A. Also known as Recombinant Human Thrombospondin Type-1 Domain-Containing Protein 7A, THSD7A. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for THSD7A. It may not necessarily be applicable to this product.

NCBI GI #

150170672

NCBI GeneID

221981

NCBI Accession #

NP_056019.1

UniProt Primary Accession #

Q9UPZ6

UniProt Related Accession #

Q9UPZ6

GenBank Nucleotide #

NM_015204.2

NCBI Official Full Name

thrombospondin type-1 domain-containing protein 7A

NCBI Official Synonym Full Names

thrombospondin type 1 domain containing 7A

NCBI Official Symbol

THSD7A

UniProt Protein Name

Thrombospondin type-1 domain-containing protein 7A

Protein Family

Thrombospondin type-1 domain-containing protein

UniProt Gene Name

THSD7A

UniProt Synonym Gene Names

KIAA0960

NCBI Protein Information

thrombospondin type-1 domain-containing protein 7A

NCBI Summary for THSD7A

The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]

UniProt Comments for THSD7A

Thrombospondin type-1 domain-containing protein 7A: Plays a role in actin cytoskeleton rearrangement.

Research Articles on THSD7A

1. We propose a revised clinical workup flow for patients with MN that recommends assessment of kidney biopsy for PLA2R1 and THSD7A antigen expression, screening for circulating anti-podocytes antibodies, and assessment for secondary causes, especially cancer, in patients with THSD7A antibodies

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with THSD7A recombinant protein

Products by Pathway	Pathway Diagram
Defective B3GALTL Causes Peters-plus Syndrome (PpS) Pathway antibodies	Defective B3GALTL Causes Peters-plus Syndrome (PpS) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Associated With O-glycosylation Of Proteins Pathway antibodies	Diseases Associated With O-glycosylation Of Proteins Pathway Diagram
Diseases Of Glycosylation Pathway antibodies	Diseases Of Glycosylation Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies	O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
O-linked Glycosylation Pathway antibodies	O-linked Glycosylation Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram

Diseases associated with THSD7A recombinant protein

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>9 publications with THSD7A and Kidney Diseases
Proteinuria Antibodies	>8 publications with THSD7A and Proteinuria
Nephritis Antibodies	>5 publications with THSD7A and Nephritis
Congenital Abnormalities Antibodies	>1 publications with THSD7A and Congenital Abnormalities

Organs/Tissues associated with THSD7A recombinant protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>13 publications with THSD7A and Kidney
Vascular Antibodies	>5 publications with THSD7A and Vascular
Bone Antibodies	>3 publications with THSD7A and Bone
Embryonic Tissue Antibodies	>3 publications with THSD7A and Embryonic Tissue
Placenta Antibodies	>2 publications with THSD7A and Placenta
Nerve Antibodies	>1 publications with THSD7A and Nerve