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GITR Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188074

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+)… More details

$300 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GITR, Recombinant Protein
Full Product Name
Recombinant human GITR protein with C-terminal human Fc and 6xHis tag
Product Gene Name
Product Synonym Names
Human GITR Protein, hFc-His tag; AITR; GITR; TNFRSF18; CD357
Sequence
GITR(Gln26 -Pro162)+h Fc(Glu99-A la330)
Host
HEK293 cells
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-25% trehalose is added as protectants before lyophilization.
Purity/Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Matching Pairs
Matching Pairs
Molecular Weight
26,000 Da
OMIM
603905
3D Structure
ModBase 3D Structure for Q9Y5U5
Source
Human
Conjugation
C-Human Fc and 6xHis tag
Reconstitution
Reconstitute with deionized water
Applications Tested/Suitable for GITR recombinant protein
Western Blot (WB)

Flow Cytometry (FC/FACS) of GITR recombinant protein

Figure 1. Human GITR Protein, hFc-His Tag on SDS-PAGE under reducing condition.
GITR Recombinant Protein – Cat# MBS188074

SDS-Page of GITR recombinant protein

Figure 1. Human GITR Protein, hFc-His Tag on SDS-PAGE under reducing condition.
GITR Recombinant Protein, SDS-Page – Cat# MBS188074

Other Notes

Small volumes of GITR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GITR purchase

MBS188074 is a recombinant protein targeting GITR. Also known as Recombinant human GITR protein with C-terminal human Fc and 6xHis tag. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for GITR. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
glucocorticoid-induced TNFR-related protein
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 18
NCBI Official Symbol
TNFRSF18
NCBI Official Synonym Symbols
AITR; GITR; CD357; GITR-D
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 18
UniProt Synonym Protein Names
Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein
UniProt Gene Name
TNFRSF18
UniProt Synonym Gene Names
AITR; GITR
UniProt Entry Name
TNR18_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 18; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation-inducible protein

UniProt Comments for GITR

TNFRSF18: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Receptor, cytokine

Chromosomal Location of Human Ortholog: 1p36.3

Cellular Component: integral to plasma membrane; extracellular region; external side of plasma membrane

Molecular Function: tumor necrosis factor receptor activity

Biological Process: tumor necrosis factor-mediated signaling pathway; apoptosis; signal transduction; negative regulation of apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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