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DNAM-1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188101

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and… More details

$290 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DNAM-1, Recombinant Protein
Full Product Name
Recombinant human DNAM-1 protein with C-terminal mouse Fc and 6xHis tag
Product Gene Name
DNAM-1 recombinant protein
Product Synonym Names
Human DNAM-1 Protein, mFc-His Tag; DNAM1; CD226; PTA1
Sequence
DNAM-1(Glu 19-Asn247) +mFc(Pro99 -Lys330)
Host
HEK293 cells
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-51% trehalose is added as protectants before lyophilization.
Purity/Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Matching Pairs
Antibody: DNAM1 Clone #DM95 (MBS188620)
Antigen: DNAM-1 (MBS188101)
Matching Pairs
Antibody: DNAM1 Clone #DM96 (MBS188621)
Antigen: DNAM-1 (MBS188101)
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Molecular Weight
38,614 Da
Chromosome Location
Chromosome: 18; NC_000018.9 (67530192..67624232, complement). Location: 18q22.3
OMIM
605397
3D Structure
ModBase 3D Structure for Q15762
Source
Human
Conjugation
C-Mouse Fc and 6xHis tag
Reconstitution
Reconstitute with deionized water
Applications Tested/Suitable for DNAM-1 recombinant protein
Western Blot (WB), ELISA (EIA)

ELISA (EIA) of DNAM-1 recombinant protein

Figure 1. Human DNAM-1 Protein, mFc-His Tag on SDS-PAGE under reducing condition.
DNAM-1 Recombinant Protein – Cat# MBS188101

SDS-Page of DNAM-1 recombinant protein

Figure 1. Human DNAM-1 Protein, mFc-His Tag on SDS-PAGE under reducing condition.
DNAM-1 Recombinant Protein, SDS-Page – Cat# MBS188101

Other Notes

Small volumes of DNAM-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DNAM-1 purchase

MBS188101 is a recombinant protein targeting DNAM-1. Also known as Recombinant human DNAM-1 protein with C-terminal mouse Fc and 6xHis tag. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for DNAM-1. It may not necessarily be applicable to this product.

NCBI GI #
171460997
NCBI GeneID
10666
NCBI Accession #
NP_006557.2
UniProt Primary Accession #
Q15762
UniProt Secondary Accession #
B2R818
UniProt Related Accession #
Q15762
GenBank Nucleotide #
NM_006566.2
NCBI Official Full Name
CD226 antigen
NCBI Official Synonym Full Names
CD226 molecule
NCBI Official Symbol
CD226
NCBI Official Synonym Symbols
PTA1; DNAM1; DNAM-1; TLiSA1
UniProt Protein Name
CD226 antigen
UniProt Synonym Protein Names
DNAX accessory molecule 1
Protein Family
CD226 antigen
UniProt Gene Name
CD226
UniProt Synonym Gene Names
DNAM1; DNAM-1
UniProt Entry Name
CD226_HUMAN
NCBI Protein Information
CD226 antigen; adhesion glycoprotein; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen

NCBI Summary for DNAM-1

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]
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UniProt Comments for DNAM-1

DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; external side of plasma membrane; lipid raft

Molecular Function: integrin binding; protein binding; cell adhesion molecule binding; protein kinase binding

Biological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; cytokine production; cell recognition; cell adhesion; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; positive regulation of mast cell activation
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Research Articles on DNAM-1

1. A CD226 three-variant haplotype is related with genetic predisposition to systemic sclerosis-related pulmonary fibrosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DNAM-1 recombinant protein

 Reference Product  PubMed Publications
 PVR recombinant protein  >15 publications with DNAM-1 and PVR
 FYN recombinant protein  >5 publications with DNAM-1 and FYN
 ITGB2 recombinant protein  >2 publications with DNAM-1 and ITGB2

Pathways associated with DNAM-1 recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with DNAM-1 recombinant protein

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >50 publications with DNAM-1 and Immune System Diseases
 Neoplasms Antibodies  >45 publications with DNAM-1 and Neoplasms
 Autoimmune Diseases Antibodies  >40 publications with DNAM-1 and Autoimmune Diseases
 Nervous System Diseases Antibodies  >12 publications with DNAM-1 and Nervous System Diseases
 Inflammation Antibodies  >10 publications with DNAM-1 and Inflammation
 Cardiovascular Diseases Antibodies  >9 publications with DNAM-1 and Cardiovascular Diseases
 Diabetes Mellitus, Type 1 Antibodies  >8 publications with DNAM-1 and Diabetes Mellitus, Type 1
 Diabetes Mellitus Antibodies  >8 publications with DNAM-1 and Diabetes Mellitus
 Necrosis Antibodies  >8 publications with DNAM-1 and Necrosis
 Respiratory Tract Diseases Antibodies  >7 publications with DNAM-1 and Respiratory Tract Diseases

Organs/Tissues associated with DNAM-1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >111 publications with DNAM-1 and Blood
 Vascular Antibodies  >8 publications with DNAM-1 and Vascular
 Lymph Node Antibodies  >6 publications with DNAM-1 and Lymph Node
 Lung Antibodies  >6 publications with DNAM-1 and Lung
 Liver Antibodies  >6 publications with DNAM-1 and Liver
 Spleen Antibodies  >4 publications with DNAM-1 and Spleen
 Thymus Antibodies  >3 publications with DNAM-1 and Thymus
 Mixed Antibodies  >3 publications with DNAM-1 and Mixed
 Uterus Antibodies  >1 publications with DNAM-1 and Uterus
 Kidney Antibodies  >1 publications with DNAM-1 and Kidney
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