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4-1bb Ligand (4-1BB) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188102

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule… More details

$290 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
4-1BB Ligand, Recombinant Protein
Full Product Name
Recombinant human 4-1BB Ligand Protein with N-mouse Fc and C-6xHis tag
Product Gene Name
4-1BB recombinant protein
Product Synonym Names
Human 4-1BB Ligand Protein, mFc-His Tag; 4-1BB Ligand;TNFSF9;CD137L
Sequence
mFc(Pro99- Lys330)+4- 1BB Ligand(Pro 52-Glu254)
Host
HEK293 cells
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-52% trehalose is added as protectants before lyophilization.
Purity/Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Matching Pairs
Antibody: 41BB Clone #DM68 (MBS188200)
Antigen: 4-1BB (MBS188102)
Matching Pairs
Antibody: 41BB Clone #DM68 (MBS188691)
Antigen: 4-1BB (MBS188102)
Molecular Weight
26,625 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (6531010..6535939). Location: 19p13.3
OMIM
606182
3D Structure
ModBase 3D Structure for P41273
Source
Human
Conjugation
N-Mouse Fc and C-6xHis tag
Reconstitution
Reconstitute with deionized water
Applications Tested/Suitable for 4-1BB recombinant protein
Western Blot (WB)

Flow Cytometry (FC/FACS) of 4-1BB recombinant protein

Figure 1. Human 4-1BB Ligand Protein, mFc-His Tag on SDS-PAGE under reducing condition.
4-1BB Recombinant Protein – Cat# MBS188102

SDS-Page of 4-1BB recombinant protein

Figure 1. Human 4-1BB Ligand Protein, mFc-His Tag on SDS-PAGE under reducing condition.
4-1BB Recombinant Protein, SDS-Page – Cat# MBS188102

Other Notes

Small volumes of 4-1BB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for 4-1BB purchase

MBS188102 is a recombinant protein targeting 4-1BB. Also known as Recombinant human 4-1BB Ligand Protein with N-mouse Fc and C-6xHis tag. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for 4-1BB. It may not necessarily be applicable to this product.

NCBI GI #
4507609
NCBI GeneID
8744
NCBI Accession #
NP_003802.1
UniProt Primary Accession #
P41273
UniProt Secondary Accession #
Q2M3S2
UniProt Related Accession #
P41273
GenBank Nucleotide #
NM_003811.3
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 9
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 9
NCBI Official Symbol
TNFSF9
NCBI Official Synonym Symbols
CD137L; 4-1BB-L
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 9
UniProt Synonym Protein Names
4-1BB ligand
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFSF9
UniProt Synonym Gene Names
4-1BBL
UniProt Entry Name
TNFL9_HUMAN
NCBI Protein Information
tumor necrosis factor ligand superfamily member 9; 4-1BBL; 4-1BB ligand; receptor 4-1BB ligand; homolog of mouse 4-1BB-L

UniProt Comments for 4-1BB

TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family.

Protein type: Cell cycle regulation; Membrane protein, integral; Cytokine; Apoptosis

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular space; plasma membrane; integral to membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; positive regulation of interferon-gamma production; positive regulation of cytotoxic T cell differentiation; cell-cell signaling; apoptosis; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; immune response; myeloid dendritic cell differentiation; signal transduction; positive regulation of activated T cell proliferation
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Research Articles on 4-1BB

1. CD137L is a novel diagnostic marker of subtypes of non-Hodgkin B-cell lymphomas.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with 4-1BB recombinant protein

 Reference Product  PubMed Publications
 TNFRSF9 recombinant protein  >54 publications with 4-1BB and TNFRSF9
 TRAF2 recombinant protein  >2 publications with 4-1BB and TRAF2
 TRAF1 recombinant protein  >1 publications with 4-1BB and TRAF1

Pathways associated with 4-1BB recombinant protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with 4-1BB recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >125 publications with 4-1BB and Necrosis
 Neoplasms Antibodies  >54 publications with 4-1BB and Neoplasms
 Inflammation Antibodies  >14 publications with 4-1BB and Inflammation
 Gastrointestinal Diseases Antibodies  >13 publications with 4-1BB and Gastrointestinal Diseases
 Lymphoma Antibodies  >13 publications with 4-1BB and Lymphoma
 Neoplasms, Experimental Antibodies  >13 publications with 4-1BB and Neoplasms, Experimental
 Liver Diseases Antibodies  >10 publications with 4-1BB and Liver Diseases
 Liver Neoplasms Antibodies  >9 publications with 4-1BB and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >8 publications with 4-1BB and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >5 publications with 4-1BB and Carcinoma, Hepatocellular

Organs/Tissues associated with 4-1BB recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >113 publications with 4-1BB and Blood
 Nerve Antibodies  >53 publications with 4-1BB and Nerve
 Bone Antibodies  >10 publications with 4-1BB and Bone
 Eye Antibodies  >4 publications with 4-1BB and Eye
 Stomach Antibodies  >3 publications with 4-1BB and Stomach
 Intestine Antibodies  >3 publications with 4-1BB and Intestine
 Brain Antibodies  >3 publications with 4-1BB and Brain
 Prostate Antibodies  >1 publications with 4-1BB and Prostate
 Cervix Antibodies  >1 publications with 4-1BB and Cervix
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