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NKp30 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188120

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region… More details

$290 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NKp30, Recombinant Protein
Full Product Name
Recombinant human NKp30 protein with C-terminal human Fc
Product Gene Name
NKp30 recombinant protein
Product Synonym Names
Human NKp30 Protein, hFc Tag; NCR3;CD337;NKp30;1C7;LY117;MALS
Sequence
NKp30(Leu1 9-Glu135)+ hFc(Glu99- Ala330)
Host
HEK293 cells
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-69% trehalose is added as protectants before lyophilization.
Purity/Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Matching Pairs
Antibody: NKp30 Clone #DM88 (MBS188220)
Antigen: NKp30 (MBS188120)
Matching Pairs
Antibody: NKp30 Clone #DM88 (MBS188711)
Antigen: NKp30 (MBS188120)
Molecular Weight
21,593 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (31556660..31560762, complement). Location: 6p21.3
OMIM
609148
3D Structure
ModBase 3D Structure for O14931
Source
Human
Conjugation
C-Human Fc tag
Reconstitution
Reconstitute with deionized water
Applications Tested/Suitable for NKp30 recombinant protein
Western Blot (WB)

ELISA (EIA) of NKp30 recombinant protein

Figure 3. B7H6 protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with 2ug/ml Human NKp30 Protein, hFc Tag (MBS188120) on Expi293 cells transfected with human B7H6 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and  Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).
NKp30 Recombinant Protein – Cat# MBS188120

SDS-Page of NKp30 recombinant protein

Figure 3. B7H6 protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with 2ug/ml Human NKp30 Protein, hFc Tag (MBS188120) on Expi293 cells transfected with human B7H6 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and  Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).
NKp30 Recombinant Protein, SDS-Page – Cat# MBS188120

Other Notes

Small volumes of NKp30 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NKp30 purchase

MBS188120 is a recombinant protein targeting NKp30. Also known as Recombinant human NKp30 protein with C-terminal human Fc. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for NKp30. It may not necessarily be applicable to this product.

NCBI GI #
224586860
NCBI GeneID
259197
NCBI Accession #
NP_001138938.1
UniProt Primary Accession #
O14931
UniProt Secondary Accession #
O14930; O14932; O95667; O95668; O95669; Q5ST89; Q5ST90; Q5ST91; B0S8F2; B0S8F4; B0S8F5
UniProt Related Accession #
O14931
GenBank Nucleotide #
NM_001145466.1
NCBI Official Full Name
natural cytotoxicity triggering receptor 3 isoform b
NCBI Official Synonym Full Names
natural cytotoxicity triggering receptor 3
NCBI Official Symbol
NCR3
NCBI Official Synonym Symbols
1C7; MALS; CD337; LY117; NKp30
UniProt Protein Name
Natural cytotoxicity triggering receptor 3
UniProt Synonym Protein Names
Activating natural killer receptor p30; Natural killer cell p30-related protein
Protein Family
Natural cytotoxicity triggering receptor
UniProt Gene Name
NCR3
UniProt Synonym Gene Names
1C7; LY117; NK-p30; NKp30
UniProt Entry Name
NCTR3_HUMAN
NCBI Protein Information
natural cytotoxicity triggering receptor 3; NK-p30; lymphocyte antigen 117; activating NK-A1 receptor; activating natural killer receptor p30; natural killer cell p30-related protein

UniProt Comments for NKp30

NCR3: Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: integral to plasma membrane

Biological Process: immune response; cell recognition; inflammatory response; positive regulation of natural killer cell mediated cytotoxicity

Disease: Malaria, Mild, Susceptibility To
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Research Articles on NKp30

1. Using a codon-optimized gene fragment, we report remarkable yields for extracellular domain of human NK cell receptor (NKp30ex) when produced on M9 minimal medium, even with low (2g/L) glucose concentration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NKp30 recombinant protein

 Products by Pathway  Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Diseases associated with NKp30 recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >16 publications with NKp30 and Necrosis
 Hepatitis C Antibodies  >9 publications with NKp30 and Hepatitis C
 Inflammation Antibodies  >7 publications with NKp30 and Inflammation
 Gastrointestinal Diseases Antibodies  >4 publications with NKp30 and Gastrointestinal Diseases
 Malaria Antibodies  >4 publications with NKp30 and Malaria
 Carcinoma, Squamous Cell Antibodies  >2 publications with NKp30 and Carcinoma, Squamous Cell
 Psoriasis Antibodies  >1 publications with NKp30 and Psoriasis
 Peripheral Nervous System Diseases Antibodies  >1 publications with NKp30 and Peripheral Nervous System Diseases
 Intestinal Diseases Antibodies  >1 publications with NKp30 and Intestinal Diseases
 Brain Diseases Antibodies  >1 publications with NKp30 and Brain Diseases

Organs/Tissues associated with NKp30 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >103 publications with NKp30 and Blood
 Spleen Antibodies  >3 publications with NKp30 and Spleen
 Lymph Node Antibodies  >3 publications with NKp30 and Lymph Node
 Brain Antibodies  >2 publications with NKp30 and Brain
 Tonsil Antibodies  >1 publications with NKp30 and Tonsil
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