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CD114 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188121

The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also… More details

$290 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD114, Recombinant Protein
Full Product Name
Recombinant human CD114 protein with C-terminal 6xHis tag
Product Gene Name
CD114 recombinant protein
Product Synonym Names
Human CD114 Protein, His Tag; CSF3R;CD114;GCSFR
Sequence
CD114(Glu2 5-Pro622)
Host
HEK293 cells
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-70% trehalose is added as protectants before lyophilization.
Purity/Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Molecular Weight
92,156 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (36931644..36948915, complement). Location: 1p35-p34.3
OMIM
138971
3D Structure
ModBase 3D Structure for Q99062
Source
Human
Conjugation
C-6xHis tag
Reconstitution
Reconstitute with deionized water
Applications Tested/Suitable for CD114 recombinant protein
Western Blot (WB)

ELISA (EIA) of CD114 recombinant protein

Figure 1. Human CD114 Protein, His Tag on SDS-PAGE under reducing condition.
CD114 Recombinant Protein – Cat# MBS188121

SDS-Page of CD114 recombinant protein

Figure 1. Human CD114 Protein, His Tag on SDS-PAGE under reducing condition.
CD114 Recombinant Protein, SDS-Page – Cat# MBS188121

Other Notes

Small volumes of CD114 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD114 purchase

MBS188121 is a recombinant protein targeting CD114. Also known as Recombinant human CD114 protein with C-terminal 6xHis tag. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD114. It may not necessarily be applicable to this product.

NCBI GI #
27437045
NCBI GeneID
1441
NCBI Accession #
NP_758519.1
UniProt Primary Accession #
Q99062
UniProt Related Accession #
Q99062
GenBank Nucleotide #
NM_172313.2
NCBI Official Full Name
granulocyte colony-stimulating factor receptor isoform d
NCBI Official Synonym Full Names
colony stimulating factor 3 receptor (granulocyte)
NCBI Official Symbol
CSF3R
NCBI Official Synonym Symbols
CD114; GCSFR
UniProt Protein Name
Granulocyte colony-stimulating factor receptor
Protein Family
Granulocyte colony-stimulating factor receptor
UniProt Gene Name
CSF3R
UniProt Synonym Gene Names
GCSFR; G-CSF receptor; G-CSF-R
UniProt Entry Name
CSF3R_HUMAN
NCBI Protein Information
granulocyte colony-stimulating factor receptor; G-CSF-R; CD114 antigen; G-CSF receptor

UniProt Comments for CD114

GCSFR: the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variant isoforms have been described.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35-p34.3

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; receptor activity

Biological Process: neutrophil chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; signal transduction; cell adhesion

Disease: Neutrophilia, Hereditary
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Research Articles on CD114

1. Certain missense single nucleotide polymorphisms, especially which are placed in the conserved regions of G-CSFR may possess the capacity to influence the response to G-CSF treatment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD114 recombinant protein

 Reference Product  PubMed Publications
 JAK2 recombinant protein  >151 publications with CD114 and JAK2
 JAK1 recombinant protein  >38 publications with CD114 and JAK1
 GRB2 recombinant protein  >26 publications with CD114 and GRB2
 SOCS3 recombinant protein  >26 publications with CD114 and SOCS3
 PTPN6 recombinant protein  >25 publications with CD114 and PTPN6
 JAK3 recombinant protein  >13 publications with CD114 and JAK3
 TYK2 recombinant protein  >12 publications with CD114 and TYK2
 CSF3 recombinant protein  >11 publications with CD114 and CSF3
 SOCS2 recombinant protein  >2 publications with CD114 and SOCS2
 UBC recombinant protein  >2 publications with CD114 and UBC

Pathways associated with CD114 recombinant protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram

Diseases associated with CD114 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1190 publications with CD114 and Neoplasms
 Necrosis Antibodies  >810 publications with CD114 and Necrosis
 Inflammation Antibodies  >456 publications with CD114 and Inflammation
 Respiratory Tract Diseases Antibodies  >241 publications with CD114 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >230 publications with CD114 and Lung Diseases
 Cardiovascular Diseases Antibodies  >159 publications with CD114 and Cardiovascular Diseases
 Asthma Antibodies  >154 publications with CD114 and Asthma
 Skin Diseases Antibodies  >129 publications with CD114 and Skin Diseases
 Nervous System Diseases Antibodies  >101 publications with CD114 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >84 publications with CD114 and Cell Transformation, Neoplastic

Organs/Tissues associated with CD114 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2941 publications with CD114 and Blood
 Bone Marrow Antibodies  >1134 publications with CD114 and Bone Marrow
 Lung Antibodies  >312 publications with CD114 and Lung
 Vascular Antibodies  >226 publications with CD114 and Vascular
 Spleen Antibodies  >179 publications with CD114 and Spleen
 Liver Antibodies  >149 publications with CD114 and Liver
 Brain Antibodies  >124 publications with CD114 and Brain
 Muscle Antibodies  >82 publications with CD114 and Muscle
 Nerve Antibodies  >80 publications with CD114 and Nerve
 Embryonic Tissue Antibodies  >76 publications with CD114 and Embryonic Tissue
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