Human SIGLEC10 Recombinant Protein – Cat# MBS188127

Figure 1. Human SIGLEC10 Protein, His Tag on SDS-PAGE under reducing condition.

SIGLEC10 Human Recombinant Protein

Name: SIGLEC10 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS188127
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188127

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune… More details

$290 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SIGLEC10, Recombinant Protein

Full Product Name

Recombinant Human SIGLEC10 protein with C-terminal 6xHis tag

Product Gene Name

SIGLEC10 recombinant protein

Product Synonym Names

Human SIGLEC10 Protein, His Tag; SIGLEC10; Siglec-10; SLG2; PRO940; MGC126774

Sequence

SIGLEC10(M et17-Thr54 6)

Host

HEK293 cells

Form/Format

Lyophilized from sterile PBS, pH 7.4. Normally 5%-76% trehalose is added as protectants before lyophilization.

Purity/Purification

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Preparation and Storage

Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice

OMIM

606091

3D Structure

ModBase 3D Structure for Q96LC7

Source

Human

Conjugation

C-6xHis tag

Reconstitution

Reconstitute with deionized water

Applications Tested/Suitable for SIGLEC10 recombinant protein

Western Blot (WB)

Other Notes

Small volumes of SIGLEC10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SIGLEC10 purchase

MBS188127 is a recombinant protein targeting SIGLEC10. Also known as Recombinant Human SIGLEC10 protein with C-terminal 6xHis tag. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for SIGLEC10. It may not necessarily be applicable to this product.

NCBI GI #

283837876

NCBI GeneID

89790

NCBI Accession #

NP_001164627.1

UniProt Primary Accession #

Q96LC7

UniProt Related Accession #

Q96LC7

GenBank Nucleotide #

NP_001164627.1

NCBI Official Full Name

sialic acid-binding Ig-like lectin 10 isoform 2

NCBI Official Synonym Full Names

sialic acid binding Ig like lectin 10

NCBI Official Symbol

SIGLEC10

NCBI Official Synonym Symbols

SLG2; PRO940; SIGLEC-10

UniProt Protein Name

Sialic acid-binding Ig-like lectin 10

UniProt Synonym Protein Names

Siglec-like protein 2

Protein Family

Sialic acid-binding Ig-like lectin

UniProt Gene Name

SIGLEC10

UniProt Synonym Gene Names

SLG2; Siglec-10

UniProt Entry Name

SIG10_HUMAN

NCBI Protein Information

sialic acid-binding Ig-like lectin 10

UniProt Comments for SIGLEC10

Siglec-10: a cell surface protein belonging to the immunoglobulin superfamily and the SIGLEC (sialic acid binding Ig-like lectin) family. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha2,3- or 2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Five alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: plasma membrane; integral to membrane; extracellular region

Molecular Function: carbohydrate binding

Biological Process: cell adhesion

Research Articles on SIGLEC10

1. Genetic ablation of either CD24 or Siglec-10, as well as blockade of the CD24-Siglec-10 interaction using monoclonal antibodies, robustly augment the phagocytosis of all CD24-expressing human tumours that we tested. Genetic ablation and therapeutic blockade of CD24 resulted in a macrophage-dependent reduction of tumour growth in vivo and an increase in survival time.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SIGLEC10 recombinant protein

Reference Product	PubMed Publications
CD24 recombinant protein	>3 publications with SIGLEC10 and CD24
PTPN6 recombinant protein	>3 publications with SIGLEC10 and PTPN6
HMGB1 recombinant protein	>2 publications with SIGLEC10 and HMGB1
HMG1 recombinant protein	>2 publications with SIGLEC10 and HMG1
PTPN11 recombinant protein	>1 publications with SIGLEC10 and PTPN11

Diseases associated with SIGLEC10 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>5 publications with SIGLEC10 and Inflammation
Necrosis Antibodies	>3 publications with SIGLEC10 and Necrosis
Drug-Induced Liver Injury Antibodies	>1 publications with SIGLEC10 and Drug-Induced Liver Injury
Fibrosis Antibodies	>1 publications with SIGLEC10 and Fibrosis
Disease Models, Animal Antibodies	>1 publications with SIGLEC10 and Disease Models, Animal

Organs/Tissues associated with SIGLEC10 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>10 publications with SIGLEC10 and Blood
Liver Antibodies	>3 publications with SIGLEC10 and Liver
Spleen Antibodies	>3 publications with SIGLEC10 and Spleen