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TGFBR1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188136

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in… More details

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Product Overview

Online Datasheet in PDF
Product Name
TGFBR1, Recombinant Protein
Full Product Name
Recombinant human CD46 Protein with C-6xHis tag
Product Gene Name
TGFBR1 recombinant protein
Product Synonym Names
Human TGFBR1 Protein, hFc Tag; AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1
Sequence
hFc(Glu99- Ala330)+TG FBR1(Leu34 -Leu126)
Host
HEK293 cells
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-117% trehalose is added as protectants before lyophilization.
Purity/Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Molecular Weight
55,960 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (101867412..101916474). Location: 9q22
OMIM
132800
3D Structure
ModBase 3D Structure for P36897
Source
Human
Conjugation
N-Human Fc tag
Reconstitution
Reconstitute with deionized water
Applications Tested/Suitable for TGFBR1 recombinant protein
Western Blot (WB)

SDS-Page of TGFBR1 recombinant protein

Figure 1. Human TGFBR1 Protein, N-hFc Tag on SDS-PAGE under reducing condition.
TGFBR1 Recombinant Protein – Cat# MBS188136

Other Notes

Small volumes of TGFBR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGFBR1 purchase

MBS188136 is a recombinant protein targeting TGFBR1. Also known as Recombinant human CD46 Protein with C-6xHis tag. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TGFBR1. It may not necessarily be applicable to this product.

NCBI GI #
195963412
NCBI GeneID
7046
NCBI Accession #
NP_001124388.1
UniProt Primary Accession #
P36897
UniProt Secondary Accession #
Q6IR47; Q706C0; Q706C1
UniProt Related Accession #
P36897
GenBank Nucleotide #
NM_001130916.1
NCBI Official Full Name
TGF-beta receptor type-1 isoform 2
NCBI Official Synonym Full Names
transforming growth factor, beta receptor 1
NCBI Official Symbol
TGFBR1
NCBI Official Synonym Symbols
AAT5; ALK5; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4
UniProt Protein Name
TGF-beta receptor type-1
UniProt Synonym Protein Names
Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I
Protein Family
TGF-beta receptor
UniProt Gene Name
TGFBR1
UniProt Synonym Gene Names
ALK5; SKR4; TGFR-1; ALK-5; ALK5; SKR4; TGF-beta receptor type I; TbetaR-I
UniProt Entry Name
TGFR1_HUMAN
NCBI Protein Information
TGF-beta receptor type-1; tbetaR-I; TGF-beta receptor type I; TGF-beta type I receptor; activin receptor-like kinase 5; transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; activin A receptor type II-like kinase, 53kD

UniProt Comments for TGFBR1

TGFBR1: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Found in all tissues; most abundant in placenta and least abundant in brain and heart.

Protein type: EC 2.7.11.30; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Kinase, protein; Receptor, misc.; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: tight junction; membrane; cell; plasma membrane; endosome; receptor complex

Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; transforming growth factor beta binding; metal ion binding; growth factor binding; receptor signaling protein activity; punt binding; SMAD binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: lens development in camera-type eye; blastocyst development; collagen fibril organization; activation of MAPKK activity; wound healing; apoptosis; regulation of protein ubiquitination; heart development; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; cell motility involved in cell locomotion; activin receptor signaling pathway; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; anterior/posterior pattern formation; regulation of transcription, DNA-dependent; extracellular structure organization and biogenesis; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; germ cell migration; angiogenesis; cell cycle arrest; kidney development; skeletal development; positive regulation of filopodium formation; pharyngeal system development; thymus development; in utero embryonic development; male gonad development; peptidyl-threonine phosphorylation; neuron fate commitment; positive regulation of cell motility; embryonic cranial skeleton morphogenesis; positive regulation of cell growth; parathyroid gland development; endothelial cell activation; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; mesenchymal cell differentiation; regulation of gene expression; skeletal morphogenesis; regulation of protein binding; negative regulation of endothelial cell proliferation; endothelial cell migration; epithelial to mesenchymal transition; artery morphogenesis; positive regulation of endothelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway

Disease: Multiple Self-healing Squamous Epithelioma, Susceptibility To
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Research Articles on TGFBR1

1. TGF-beta1 and its receptors including TGF-betaRI and TGF-betaRII are abnormally expressed in the peripheral blood of immune thrombocytopenic purpura patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TGFBR1 recombinant protein

 Reference Product  PubMed Publications
 TGFBR2 recombinant protein  >106 publications with TGFBR1 and TGFBR2
 TGFB1 recombinant protein  >47 publications with TGFBR1 and TGFB1
 SMAD2 recombinant protein  >22 publications with TGFBR1 and SMAD2
 SMAD3 recombinant protein  >19 publications with TGFBR1 and SMAD3
 SMAD7 recombinant protein  >14 publications with TGFBR1 and SMAD7
 SMAD4 recombinant protein  >12 publications with TGFBR1 and SMAD4
 TGFB2 recombinant protein  >9 publications with TGFBR1 and TGFB2
 TGFB3 recombinant protein  >7 publications with TGFBR1 and TGFB3
 ACVRL1 recombinant protein  >5 publications with TGFBR1 and ACVRL1
 ACVR1 recombinant protein  >4 publications with TGFBR1 and ACVR1

Pathways associated with TGFBR1 recombinant protein

 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with TGFBR1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >82 publications with TGFBR1 and Neoplasms
 Loeys-Dietz Syndrome Antibodies  >47 publications with TGFBR1 and Loeys-Dietz Syndrome
 LOEYS-DIETZ SYNDROME, TYPE 1A Antibodies  >44 publications with TGFBR1 and LOEYS-DIETZ SYNDROME, TYPE 1A
 Heart Diseases Antibodies  >40 publications with TGFBR1 and Heart Diseases
 Colorectal Neoplasms Antibodies  >30 publications with TGFBR1 and Colorectal Neoplasms
 Aneurysm, Dissecting Antibodies  >23 publications with TGFBR1 and Aneurysm, Dissecting
 Inflammation Antibodies  >9 publications with TGFBR1 and Inflammation
 Disease Models, Animal Antibodies  >9 publications with TGFBR1 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >7 publications with TGFBR1 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >6 publications with TGFBR1 and Neoplasms, Experimental

Organs/Tissues associated with TGFBR1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >38 publications with TGFBR1 and Vascular
 Connective Tissue Antibodies  >29 publications with TGFBR1 and Connective Tissue
 Blood Antibodies  >26 publications with TGFBR1 and Blood
 Muscle Antibodies  >20 publications with TGFBR1 and Muscle
 Bone Antibodies  >20 publications with TGFBR1 and Bone
 Heart Antibodies  >15 publications with TGFBR1 and Heart
 Lung Antibodies  >14 publications with TGFBR1 and Lung
 Embryonic Tissue Antibodies  >11 publications with TGFBR1 and Embryonic Tissue
 Skin Antibodies  >11 publications with TGFBR1 and Skin
 Kidney Antibodies  >11 publications with TGFBR1 and Kidney
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