• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TweakR Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188144

TNFRSF12A (TNF Receptor Superfamily Member 12A) is a Protein Coding gene. Diseases associated with TNFRSF12A include Multiple Sclerosis and Stroke, Ischemic. Among its related pathways are ERK Signaling and CDK-mediated phosphorylation and removal of… More details

$285 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TweakR, Recombinant Protein
Full Product Name
Recombinant human TweakR protein with C-terminal mouse Fc tag
Product Gene Name
TweakR recombinant protein
Product Synonym Names
Human TweakR Protein, mFc Tag; TNFRSF12A; FGF-inducible 14; FN14; TweakR; CD266
Sequence
TweakR(Glu 28-Pro80)+ mFc(Pro99- Lys330)
Host
HEK293 cells
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-84% trehalose is added as protectants before lyophilization.
Purity/Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Molecular Weight
10,191 Da
OMIM
605914
3D Structure
ModBase 3D Structure for Q9NP84
Source
Human
Conjugation
C-Mouse Fc tag
Reconstitution
Reconstitute with deionized water
Applications Tested/Suitable for TweakR recombinant protein
Western Blot (WB)

ELISA (EIA) of TweakR recombinant protein

Figure 1. Human TweakR Protein, mFc Tag on SDS-PAGE under non-reducing (NR) and reducing (R) conditions.
TweakR Recombinant Protein – Cat# MBS188144

SDS-Page of TweakR recombinant protein

Figure 1. Human TweakR Protein, mFc Tag on SDS-PAGE under non-reducing (NR) and reducing (R) conditions.
TweakR Recombinant Protein, SDS-Page – Cat# MBS188144

Other Notes

Small volumes of TweakR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TweakR purchase

MBS188144 is a recombinant protein targeting TweakR. Also known as Recombinant human TweakR protein with C-terminal mouse Fc tag. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for TweakR. It may not necessarily be applicable to this product.

NCBI GI #
7706186
NCBI GeneID
51330
NCBI Accession #
NP_057723.1
UniProt Primary Accession #
Q9NP84
UniProt Secondary Accession #
Q9HCS0; D3DUA6
UniProt Related Accession #
Q9NP84
GenBank Nucleotide #
NM_016639.2
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 12A
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 12A
NCBI Official Symbol
TNFRSF12A
NCBI Official Synonym Symbols
FN14; CD266; TWEAKR
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 12A
UniProt Synonym Protein Names
Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD_antigen: CD266
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFRSF12A
UniProt Synonym Gene Names
FN14; FGF-inducible 14; TweakR
UniProt Entry Name
TNR12_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 12A; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; tweak-receptor; type I transmembrane protein Fn14

UniProt Comments for TweakR

TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: ruffle; cell surface; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: substrate-bound cell migration, cell attachment to substrate; positive regulation of apoptosis; positive regulation of axon extension; angiogenesis; regulation of angiogenesis
Show more

Research Articles on TweakR

1. Results position TWEAK-Fn14 signaling through Mcl-1 as a significant mechanism for NSCLC tumor cell survival

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TweakR recombinant protein

 Reference Product  PubMed Publications
 TNFSF12 recombinant protein  >5 publications with TweakR and TNFSF12
 TNFRSF25 recombinant protein  >1 publications with TweakR and TNFRSF25

Pathways associated with TweakR recombinant protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TWEAK Signaling Pathway antibodies  TWEAK Signaling Pathway Diagram

Diseases associated with TweakR recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >14 publications with TweakR and Necrosis
 Inflammation Antibodies  >9 publications with TweakR and Inflammation
 Neoplasms, Experimental Antibodies  >4 publications with TweakR and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >3 publications with TweakR and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with TweakR and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >3 publications with TweakR and Adenocarcinoma
 Lung Diseases Antibodies  >3 publications with TweakR and Lung Diseases
 Heart Diseases Antibodies  >2 publications with TweakR and Heart Diseases
 Disease Models, Animal Antibodies  >2 publications with TweakR and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with TweakR and Breast Neoplasms

Organs/Tissues associated with TweakR recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >7 publications with TweakR and Vascular
 Lung Antibodies  >7 publications with TweakR and Lung
 Muscle Antibodies  >5 publications with TweakR and Muscle
 Blood Antibodies  >4 publications with TweakR and Blood
 Eye Antibodies  >3 publications with TweakR and Eye
 Kidney Antibodies  >2 publications with TweakR and Kidney
 Heart Antibodies  >2 publications with TweakR and Heart
 Bone Antibodies  >2 publications with TweakR and Bone
 Brain Antibodies  >1 publications with TweakR and Brain
 Intestine Antibodies  >1 publications with TweakR and Intestine
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000