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GITR Ligand (GITR) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188157

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GITR Ligand, Recombinant Protein
Full Product Name
Recombinant human GITR protein with C-terminal His tag
Product Gene Name
GITR recombinant protein
Product Synonym Names
Human GITR Ligand Protein, His tag; TNFSF18; AITRL; TL6; hGITRL; GITR Ligand
Sequence
GITR Ligand(Gln 50-Ser177)
Host
HEK293 cells
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-97% trehalose is added as protectants before lyophilization.
Purity/Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Molecular Weight
22,724 Da
OMIM
603898
3D Structure
ModBase 3D Structure for Q9UNG2
Source
Human
Conjugation
C-His tag
Reconstitution
Reconstitute with deionized water
Applications Tested/Suitable for GITR recombinant protein
Western Blot (WB)

Flow Cytometry (FC/FACS) of GITR recombinant protein

Figure 1. Human GITR Ligand Protein, His Tag on SDS-PAGE under reducing condition.
GITR Recombinant Protein – Cat# MBS188157

SDS-Page of GITR recombinant protein

Figure 1. Human GITR Ligand Protein, His Tag on SDS-PAGE under reducing condition.
GITR Recombinant Protein, SDS-Page – Cat# MBS188157

Other Notes

Small volumes of GITR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GITR purchase

MBS188157 is a recombinant protein targeting GITR. Also known as Recombinant human GITR protein with C-terminal His tag. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for GITR. It may not necessarily be applicable to this product.

NCBI GI #
157419142
NCBI GeneID
8995
NCBI Accession #
NP_005083.2
UniProt Primary Accession #
Q9UNG2
UniProt Secondary Accession #
O95852; Q6ISV1; A9IQG8
UniProt Related Accession #
Q9UNG2
GenBank Nucleotide #
NM_005092.3
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 18
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 18
NCBI Official Symbol
TNFSF18
NCBI Official Synonym Symbols
TL6; AITRL; GITRL; hGITRL
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 18
UniProt Synonym Protein Names
Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL
UniProt Gene Name
TNFSF18
UniProt Synonym Gene Names
AITRL; GITRL; TL6; AITRL; hGITRL
UniProt Entry Name
TNF18_HUMAN
NCBI Protein Information
tumor necrosis factor ligand superfamily member 18; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand

UniProt Comments for GITR

TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family.

Protein type: Membrane protein, integral; Apoptosis; Cytokine

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: extracellular space; cell surface; plasma membrane; integral to membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding

Biological Process: tumor necrosis factor-mediated signaling pathway; cell-cell signaling; T cell proliferation during immune response; regulation of T cell proliferation; signal transduction; negative regulation of apoptosis; activation of NF-kappaB transcription factor
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Research Articles on GITR

1. Our findings indicate the possible involvement of GITR-GITRL pathway in the pathogenesis of pSS.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GITR recombinant protein

 Reference Product  PubMed Publications
 TNFRSF18 recombinant protein  >52 publications with GITR and TNFRSF18
 CD4 recombinant protein  >42 publications with GITR and CD4
 IL2RA recombinant protein  >5 publications with GITR and IL2RA
 ICOSLG recombinant protein  >4 publications with GITR and ICOSLG
 TNFRSF4 recombinant protein  >1 publications with GITR and TNFRSF4

Pathways associated with GITR recombinant protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with GITR recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >101 publications with GITR and Necrosis
 Inflammation Antibodies  >19 publications with GITR and Inflammation
 Neoplasms, Experimental Antibodies  >9 publications with GITR and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >8 publications with GITR and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >2 publications with GITR and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with GITR and Liver Neoplasms
 Atherosclerosis Antibodies  >2 publications with GITR and Atherosclerosis
 Breast Neoplasms Antibodies  >2 publications with GITR and Breast Neoplasms
 Lung Diseases Antibodies  >1 publications with GITR and Lung Diseases
 Lung Injury Antibodies  >1 publications with GITR and Lung Injury

Organs/Tissues associated with GITR recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with GITR and Brain
 Vascular Antibodies  >4 publications with GITR and Vascular
 Muscle Antibodies  >3 publications with GITR and Muscle
 Mixed Antibodies  >2 publications with GITR and Mixed
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