Human IgG1-Fc Recombinant Protein – Cat# MBS188171

Figure 1. Human IgG1-Fc Protein on SDS-PAGE under reducing condition.

IgG1-Fc Human Recombinant Protein

Name: IgG1-Fc Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS188171
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188171

IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)) is a Protein Coding gene. Diseases associated with IGHG1 include Leukemia, Chronic Lymphocytic and Heavy Chain Deposition Disease. Among its related pathways are Interleukin-4 and 13… More details

$280 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IgG1-Fc, Recombinant Protein

Full Product Name

Recombinant Human IgG1-Fc Protein

Product Gene Name

IgG1-Fc recombinant protein

Product Synonym Names

Human IgG1-Fc Protein; IgG1 Fc Protein

Sequence

hFc(Glu99- Ala330)

Host

HEK293 cells

Form/Format

Lyophilized from sterile PBS, pH 7.4. Normally 5%-111% trehalose is added as protectants before lyophilization.

Purity/Purification

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Preparation and Storage

Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice

Molecular Weight

150,000

Chromosome Location

Chromosome: 14; NC_000014.8 (106207810..106209407, complement). Location: 14q32.33

OMIM

147100

3D Structure

ModBase 3D Structure for P01857

Source

Human

Conjugation

No tag

Reconstitution

Reconstitute with deionized water

Applications Tested/Suitable for IgG1-Fc recombinant protein

Western Blot (WB)

Other Notes

Small volumes of IgG1-Fc recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IgG1-Fc purchase

MBS188171 is a recombinant protein targeting IgG1-Fc. Also known as Recombinant Human IgG1-Fc Protein. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IgG1-Fc. It may not necessarily be applicable to this product.

NCBI GI #

121039

NCBI GeneID

3500

NCBI Accession #

P01857.1

UniProt Primary Accession #

P01857

UniProt Related Accession #

P01857

NCBI Official Full Name

Ig gamma-1 chain C region

NCBI Official Synonym Full Names

immunoglobulin heavy constant gamma 1 (G1m marker)

NCBI Official Symbol

IGHG1

UniProt Protein Name

Ig gamma-1 chain C region

UniProt Gene Name

IGHG1

UniProt Entry Name

IGHG1_HUMAN

UniProt Comments for IgG1-Fc

IGHG1: Defects in IGHG1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

Protein type: Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; antigen binding

Biological Process: innate immune response; complement activation, classical pathway; complement activation

Disease: Myeloma, Multiple

Research Articles on IgG1-Fc

1. The presence of IGHG1 in pancreatic cancer cells might constitute an important element responsible for tumor cell proliferation and immune evasion mechanisms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IgG1-Fc recombinant protein

Reference Product	PubMed Publications
IGKC recombinant protein	>1 publications with IgG1-Fc and IGKC

Pathways associated with IgG1-Fc recombinant protein

Products by Pathway	Pathway Diagram
Classical Antibody-mediated Complement Activation Pathway antibodies	Classical Antibody-mediated Complement Activation Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Creation Of C4 And C2 Activators Pathway antibodies	Creation Of C4 And C2 Activators Pathway Diagram
FCGR Activation Pathway antibodies	FCGR Activation Pathway Diagram
Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies	Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway antibodies	Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway Diagram

Organs/Tissues associated with IgG1-Fc recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11 publications with IgG1-Fc and Blood
Lymph Antibodies	>2 publications with IgG1-Fc and Lymph
Lymph Node Antibodies	>2 publications with IgG1-Fc and Lymph Node
Intestine Antibodies	>2 publications with IgG1-Fc and Intestine
Skin Antibodies	>2 publications with IgG1-Fc and Skin
Bone Antibodies	>1 publications with IgG1-Fc and Bone
Bone Marrow Antibodies	>1 publications with IgG1-Fc and Bone Marrow
Thyroid Antibodies	>1 publications with IgG1-Fc and Thyroid
Pancreas Antibodies	>1 publications with IgG1-Fc and Pancreas
Uterus Antibodies	>1 publications with IgG1-Fc and Uterus