E. coli K99 Pili Monoclonal Antibody (Clone K9912-444.5)

This mouse monoclonal antibody (Clone K9912-444.5) targets the K99 (F5) fimbrial adhesin of enterotoxigenic Escherichia coli and has been validated for use in ELISA to detect K99+ ETEC strains, supporting research into neonatal calf, lamb, and piglet diarrhea caused by K99-expressing ETEC colonization.

Bovine enteric colibacillosis is an economically important disease in neonatal calves caused by enterotoxigenic E. coli (ETEC) which adhere to intestinal cells using pili. Most ETEC isolated from cattle use K99 pili to bind to enterocytes of the small intestine. K99 pili are primarily composed of a repeating 18.2kDa major subunit which is responsible for binding to host glycoprotein receptor, N-glycolylneuraminic acid-GM3. A 7.1kb operon of eight genes on a plasmid encode the pili and other associated proteins responsible for regulation, transport, and assembly of K99 pili.

Small volumes of anti-E Coli K99 pili antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS190130 is an antibody targeting E Coli K99 pili. Also known as E. coli K99 Pilus Monoclonal Antibody. Host: Mouse.