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Gonadotropin Releasing Hormone (GNRH1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS190177

MBS190177 is an antibody targeting GNRH1. Also known as Gonadotropin Releasing Hormone Monoclonal Antibody. Host: Mouse. More details

$330 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Gonadotropin Releasing Hormone (GNRH1), Monoclonal Antibody
Full Product Name
Gonadotropin Releasing Hormone Monoclonal Antibody
Product Gene Name
Product Synonym Names
Anti-Gonadotropin Releasing Hormone; GnRH
Clonality
Monoclonal
Isotype
IgG1
Host
Mouse
Form/Format
1 ml ascites or 1 mg Protein G-purified antibody in PBS, pH 7.4.
Specificity
Anti-Gonadotropin Releasing Hormone [Murine MAbs recognize human gonadotropin releasing hormone (4 clones). LP]
Preparation and Storage
These antibodies are stable for at least one (1) year at -20 degree to-70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Molecular Weight
10,380 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (25276774..25282556, complement). Location: 8p21-p11.2
OMIM
152760
3D Structure
ModBase 3D Structure for P01148
Antigen
Purified human gonadotropin releasing hormone.
Activity
Ig mg/ml*: 16.4
ELISA Titer**: 1: 25,600
ng GnRH for 50% Displacement: 8.85
(Note: * Determined by radial immunodiffusion for several lots of ascites.
**ELISA is an indirect assay against human GnRH on the solid phase. Titers represent endpoint dilutions that achieve absorbance values >= 0.1.)
Stabilizer
None.
Preservatives
None. Available on request.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Applications Tested/Suitable for anti-GNRH1 antibody
ELISA, Immunohistochemistry
Application Notes for anti-GNRH1 antibody
These antibodies may be used in ELISA, immunohistochemistry and RIA to detect and quantitate GnRH.

Product References and Citations for anti-GNRH1 antibody

Rajendren G and Gibson MJ (2001) J Neuroendocrinology 13: 270-274.

Other Notes

Small volumes of anti-GNRH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GNRH1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
gonadotropin-releasing hormone
NCBI Official Synonym Full Names
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
NCBI Official Symbol
GNRH1
NCBI Official Synonym Symbols
GRH; GNRH; LHRH; LNRH
UniProt Protein Name
Progonadoliberin-1
UniProt Synonym Protein Names
Progonadoliberin ICleaved into the following 2 chains:Gonadoliberin-1; Alternative name(s):; Gonadoliberin I; Gonadorelin; Gonadotropin-releasing hormone I; GnRH-I; Luliberin I; Luteinizing hormone-releasing hormone I; LH-RH IGnRH-associated peptide 1; Alternative name(s):; GnRH-associated peptide I
Protein Family
UniProt Gene Name
GNRH1
UniProt Synonym Gene Names
GNRH; GRH; LHRH
UniProt Entry Name
GON1_HUMAN
NCBI Protein Information
progonadoliberin-1; luliberin I; OTTHUMP00000225172; OTTHUMP00000225173; progonadoliberin I; GnRH-associated peptide 1; prolactin release-inhibiting factor; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)

NCBI Summary for GNRH1

The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH), also known as gonadoliberin-1, and prolactin release-inhibiting factor, also known as GnRH-associated peptide 1. LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
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UniProt Comments for GNRH1

GNRH1: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. Belongs to the GnRH family.

Protein type: Secreted, signal peptide; Cell cycle regulation; Hormone; Secreted

Chromosomal Location of Human Ortholog: 8p21-p11.2

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity; luteinizing hormone-releasing factor activity

Biological Process: negative regulation of cell proliferation; ovulation cycle; response to ethanol; cell-cell signaling; regulation of gene expression; multicellular organismal development; female pregnancy; signal transduction; response to corticosteroid stimulus; negative regulation of apoptosis

Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GNRH1 antibody

 Reference Product  PubMed Publications
 GNRHR antibody  >16 publications with GNRH1 and GNRHR
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