Mouse Anti-TBP Monoclonal Antibody – Cat# MBS190431

TATA - Binding Protein (TBP) Antibody – Mouse Monoclonal

Name: TBP Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS190431
Price: 555 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS190431

MBS190431 is an antibody targeting Tbp. Also known as TATA-Binding Protein Monoclonal Antibody. Host: Mouse. More details

$555 / 0.2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TATA - Binding Protein (Tbp), Monoclonal Antibody

Full Product Name

TATA-Binding Protein Monoclonal Antibody

Product Gene Name

anti-Tbp antibody

Product Synonym Names

Anti-TATA - Binding Protein; TATA Binding Protein (TBP)

Clonality

Monoclonal

Isotype

IgG1

Host

Mouse

Form/Format

200 ug Protein G purified antibody in PBS, pH 7.4.

Specificity

Anti-TATA - Binding Protein [Murine MAb recognizes epitope within aa residues 1-20 of human, mouse and rat TBP.]
This antibody recognizes an epitope within amino acid residues 1-20 of human, mouse and rat TBP. It does not react with TBP from Drosophila, yeast, silk worm, or Xenopus. The specific epitope for this antibody is accessible when the C-terminal domain of TBP is removed or when TBP is complexed with DNA.

Preparation and Storage

These antibodies are stable for at least one (1) year at -20 degree C to -70 degree C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles

Molecular Weight

38,451 Da

Chromosome Location

Chromosome: 2R; NT_033778.3 (17573705..17575145, complement). Location: 57F8-57F8

3D Structure

ModBase 3D Structure for P20227

Antigen

N-terminal domain of the human TATA-binding protein (TBP).

Preservatives

None. Available on request

Dilutions Instructions

Dilute in PBS or medium which is identical to that used in the assay system.

Product Categories/Family for anti-Tbp antibody

Protein Transcription Antibodies

Applications Tested/Suitable for anti-Tbp antibody

Western Blot, Immunoprecipitation

Application Notes for anti-Tbp antibody

This antibody may be used in Western Blot and electrophoretic mobility (gel shift) assays to detect mammalian TBP. It may also be used to immunoprecipitate a truncated TBP molecule containing only the N-terminal domain.

Other Notes

Small volumes of anti-Tbp antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Tbp. It may not necessarily be applicable to this product.

NCBI GI #

17647997

NCBI GeneID

37476

NCBI Accession #

NP_523805.1

UniProt Primary Accession #

P20227

UniProt Secondary Accession #

Q9W2D8

UniProt Related Accession #

P20227

GenBank Nucleotide #

NM_079081.3

NCBI Official Full Name

TATA binding protein

NCBI Official Synonym Full Names

TATA binding protein

NCBI Official Symbol

Tbp

NCBI Official Synonym Symbols

CG9874; DmelCG9874; dTbp; dTBP; dTFIID; RBP; TBP; TBP38; TfIID; TFIID; TFIIDtau

UniProt Protein Name

TATA-box-binding protein

UniProt Synonym Protein Names

TATA sequence-binding protein; TATA-binding factor; TATA-box factor; Transcription initiation factor TFIID TBP subunit

Protein Family

TATA-box-binding protein

UniProt Gene Name

Tbp

UniProt Synonym Gene Names

BTF1; TFIID

UniProt Entry Name

TBP_DROME

NCBI Protein Information

CG9874 gene product from transcript CG9874-RA; TATA binding protein; CG9874-PA; Tbp-PA; TATA box binding protein; 42kDa polypeptide; TATA box-binding protein; TATA-binding protein; TATA-box binding protein

UniProt Comments for Tbp

Function: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Ref.1 Ref.2 Ref.8

Subunit structure: Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Binds DNA as monomer. Interacts with TFIIA-L heterotrimer. Interacts with Taf1, Taf2, Taf5 and Taf12. Ref.8 Ref.9 Ref.10 Ref.11 Ref.12

Subcellular location: Nucleus.

Sequence similarities: Belongs to the TBP family.

Research Articles on Tbp

1. TBP activates TATA-dependent transcription and represses DPE-dependent transcription, whereas Mot1 and NC2 block TBP function and thus repress TATA-dependent transcription and activate DPE-dependent transcription.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Tbp antibody

Products by Pathway	Pathway Diagram
Basal Transcription Factors Pathway antibodies	Basal Transcription Factors Pathway Diagram
Basal Transcription Factors Pathway antibodies	Basal Transcription Factors Pathway Diagram
Eukaryotic Transcription Initiation Pathway antibodies	Eukaryotic Transcription Initiation Pathway Diagram
Formation And Maturation Of MRNA Transcript Pathway antibodies	Formation And Maturation Of MRNA Transcript Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies	RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
RNA Polymerase II Pre-transcription Events Pathway antibodies	RNA Polymerase II Pre-transcription Events Pathway Diagram
RNA Polymerase II Promoter Escape Pathway antibodies	RNA Polymerase II Promoter Escape Pathway Diagram
RNA Polymerase II Transcription Pathway antibodies	RNA Polymerase II Transcription Pathway Diagram
RNA Polymerase II Transcription Initiation Pathway antibodies	RNA Polymerase II Transcription Initiation Pathway Diagram

Diseases associated with anti-Tbp antibody

Disease Name	Pubmed Publications
Spinocerebellar Ataxias Antibodies	>45 publications with Tbp and Spinocerebellar Ataxias
Death Antibodies	>37 publications with Tbp and Death
Necrosis Antibodies	>34 publications with Tbp and Necrosis
Breast Neoplasms Antibodies	>24 publications with Tbp and Breast Neoplasms
Cell Transformation, Neoplastic Antibodies	>21 publications with Tbp and Cell Transformation, Neoplastic
Adenocarcinoma Antibodies	>20 publications with Tbp and Adenocarcinoma
Inflammation Antibodies	>20 publications with Tbp and Inflammation
Kidney Diseases Antibodies	>18 publications with Tbp and Kidney Diseases
Carcinoma, Hepatocellular Antibodies	>16 publications with Tbp and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>14 publications with Tbp and Liver Neoplasms

Organs/Tissues associated with anti-Tbp antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>21 publications with Tbp and Embryonic Tissue
Ovary Antibodies	>18 publications with Tbp and Ovary
Whole Body Antibodies	>9 publications with Tbp and Whole Body