LAMP2 Antibody – Rat Monoclonal

Lysosome-associated membrane proteins (LAMP1 and LAMP2) are major constituents of the lysosomal membrane. These two proteins have closely related structures with 37% sequence homology. Both are transmembrane glycoproteins localized primarily in lysosomes and late endosomes. LAMP2 has also been detected at the plasma membrane of cells undergoing differentiation and activation and in cells that secrete lysosomal hydrolases. In addition, it has been suggested that LAMP2 is involved in cell-cell or cell-extracellular matrix interactions. Cell surface LAMP1 and LAMP2 promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium which suggests that the LAMP proteins are involved in adhesion of PBMC to sites of inflammation. Studies with LAMP2-deficient mice indicate that involvement of LAMP2 is critical in the conversion of early autophagic vacuoles to vacuoles which rapidly degrade their contents. Defects in LAMP2 are associated with Danon disease.

Granger, BL et al. 1990 J Biol Chem 265: 12036-12043

Small volumes of anti-LAMP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS190486 is an antibody targeting LAMP2. Also known as Anti-LAMP2 Monoclonal Antibody. Host: Rat.